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Acinar ventilation heterogeneity in COPD relates to diffusion capacity, resistance and reactance.

Jarenbäck, Linnea LU ; Ankerst, Jaro LU ; Bjermer, Leif LU and Tufvesson, Ellen LU (2016) In Respiratory Medicine 110(nov 11). p.28-33
Abstract
The aim of this study was to investigate heterogenic ventilation in the acinar (Sacin) and conductive (Scond) airways of patients with varying chronic obstructive pulmonary disease (COPD) severity and how these relates to advanced lung function parameters, primarily measured by impulse oscillometry (IOS). A secondary aim was to investigate the effects of a short acting beta2-agonist and a muscarinic antagonist on the heterogenic ventilation. Eleven never smoking controls, 12 smoking controls, and 57 COPD patients (7 GOLD 1, 25 GOLD 2, 14 GOLD 3 and 11 GOLD 4) performed flow-volume spirometry, IOS, body plethysmography, single breath carbon monoxide diffusion, and N2-multiple breath washout. Six smoking controls and 13 of the COPD patients... (More)
The aim of this study was to investigate heterogenic ventilation in the acinar (Sacin) and conductive (Scond) airways of patients with varying chronic obstructive pulmonary disease (COPD) severity and how these relates to advanced lung function parameters, primarily measured by impulse oscillometry (IOS). A secondary aim was to investigate the effects of a short acting beta2-agonist and a muscarinic antagonist on the heterogenic ventilation. Eleven never smoking controls, 12 smoking controls, and 57 COPD patients (7 GOLD 1, 25 GOLD 2, 14 GOLD 3 and 11 GOLD 4) performed flow-volume spirometry, IOS, body plethysmography, single breath carbon monoxide diffusion, and N2-multiple breath washout. Six smoking controls and 13 of the COPD patients also performed double reversibility test by using salbutamol and its combination with ipratropium. Sacin was significantly higher in GOLD 2-4 compared to never smoking controls and smoking controls, but showed similar levels in GOLD 3 and 4. A factor analysis identified 4 components consisting of; 1) IOS parameters, 2) volume parameters, 3) diffusion parameters, Sacin and some IOS parameters and 4) Scond with central obstruction/air trapping. Salbutamol and its combination with ipratropium had no effect on Sacin and Scond. Increased Sacin in COPD was strongly related to diffusion capacity and lung volumes, but also weakly to resistance and reactance, showing a link between ventilation heterogeneity in the acinar airways and parameters measured by IOS. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Respiratory Medicine
volume
110
issue
nov 11
pages
28 - 33
publisher
Elsevier
external identifiers
  • pmid:26607879
  • wos:000367380700004
  • scopus:84952871289
ISSN
1532-3064
DOI
10.1016/j.rmed.2015.11.005
language
English
LU publication?
yes
id
7682be49-cfc6-400d-91ed-77adb45f57c7 (old id 8234525)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26607879?dopt=Abstract
date added to LUP
2015-12-02 20:36:38
date last changed
2017-08-27 03:30:00
@article{7682be49-cfc6-400d-91ed-77adb45f57c7,
  abstract     = {The aim of this study was to investigate heterogenic ventilation in the acinar (Sacin) and conductive (Scond) airways of patients with varying chronic obstructive pulmonary disease (COPD) severity and how these relates to advanced lung function parameters, primarily measured by impulse oscillometry (IOS). A secondary aim was to investigate the effects of a short acting beta2-agonist and a muscarinic antagonist on the heterogenic ventilation. Eleven never smoking controls, 12 smoking controls, and 57 COPD patients (7 GOLD 1, 25 GOLD 2, 14 GOLD 3 and 11 GOLD 4) performed flow-volume spirometry, IOS, body plethysmography, single breath carbon monoxide diffusion, and N2-multiple breath washout. Six smoking controls and 13 of the COPD patients also performed double reversibility test by using salbutamol and its combination with ipratropium. Sacin was significantly higher in GOLD 2-4 compared to never smoking controls and smoking controls, but showed similar levels in GOLD 3 and 4. A factor analysis identified 4 components consisting of; 1) IOS parameters, 2) volume parameters, 3) diffusion parameters, Sacin and some IOS parameters and 4) Scond with central obstruction/air trapping. Salbutamol and its combination with ipratropium had no effect on Sacin and Scond. Increased Sacin in COPD was strongly related to diffusion capacity and lung volumes, but also weakly to resistance and reactance, showing a link between ventilation heterogeneity in the acinar airways and parameters measured by IOS.},
  author       = {Jarenbäck, Linnea and Ankerst, Jaro and Bjermer, Leif and Tufvesson, Ellen},
  issn         = {1532-3064},
  language     = {eng},
  number       = {nov 11},
  pages        = {28--33},
  publisher    = {Elsevier},
  series       = {Respiratory Medicine},
  title        = {Acinar ventilation heterogeneity in COPD relates to diffusion capacity, resistance and reactance.},
  url          = {http://dx.doi.org/10.1016/j.rmed.2015.11.005},
  volume       = {110},
  year         = {2016},
}