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Inhibition of mitogen-activated protein kinase 1/2 in the acute phase of stroke improves long-term neurological outcome and promotes recovery processes in rats.

Mostajeran, Maryam LU ; Edvinsson, Lars LU ; Warfvinge, Karin LU ; Singh, Rushani and Ansar, Saema LU (2015) In Acta Physiologica
Abstract
Extracellular signal-regulated kinase (ERK) 1/2 is activated during acute phase of stroke and contributes to stroke pathology. We have found that acute treatment with MEK1/2 inhibitors decrease infarct size and neurological deficits two days after experimental stroke. However it is not known whether benefits of this inhibition persist long-term. Therefore, the aim of this study was to assess neurological function, infarct size and recovery processes 14 days after stroke in male rats to determine long-term outcome following acute treatment with the MEK1/2 inhibitor U0126.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Physiologica
publisher
Wiley-Blackwell
external identifiers
  • pmid:26595054
  • scopus:84952042866
ISSN
1748-1708
DOI
10.1111/apha.12632
language
English
LU publication?
yes
id
948cb383-d36b-4160-881d-b1d7ffa7d788 (old id 8234885)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26595054?dopt=Abstract
date added to LUP
2015-12-06 12:21:24
date last changed
2016-12-21 09:40:07
@article{948cb383-d36b-4160-881d-b1d7ffa7d788,
  abstract     = {Extracellular signal-regulated kinase (ERK) 1/2 is activated during acute phase of stroke and contributes to stroke pathology. We have found that acute treatment with MEK1/2 inhibitors decrease infarct size and neurological deficits two days after experimental stroke. However it is not known whether benefits of this inhibition persist long-term. Therefore, the aim of this study was to assess neurological function, infarct size and recovery processes 14 days after stroke in male rats to determine long-term outcome following acute treatment with the MEK1/2 inhibitor U0126.},
  author       = {Mostajeran, Maryam and Edvinsson, Lars and Warfvinge, Karin and Singh, Rushani and Ansar, Saema},
  issn         = {1748-1708},
  language     = {eng},
  month        = {11},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Physiologica},
  title        = {Inhibition of mitogen-activated protein kinase 1/2 in the acute phase of stroke improves long-term neurological outcome and promotes recovery processes in rats.},
  url          = {http://dx.doi.org/10.1111/apha.12632},
  year         = {2015},
}