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Revisiting the role of the mast cell in asthma.

Andersson, Cecilia LU ; Tufvesson, Ellen LU ; Diamant, Zuzana LU and Bjermer, Leif LU (2016) In Current Opinion in Pulmonary Medicine 22(1). p.10-17
Abstract
In humans, mast cells are ubiquitously present in tissues adjacent to external environment and consequently have an important sentential role in host defence, homeostasis and repair. Their key role in allergen-mediated conditions has been recognized for many decades already. So far, therapies targeting mast cells offered clinical efficacy in allergic conditions except for asthma. More recently, sophisticated sampling and detection techniques revealed pleiotrophic immunological and functional properties of mast cells in and beyond asthma with potential clinical and management implications. These findings bring back the mast cell as a key player in the field of asthma and warrant a review of the recent literature.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Opinion in Pulmonary Medicine
volume
22
issue
1
pages
10 - 17
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:26574723
  • scopus:84948572836
  • wos:000369646600003
ISSN
1531-6971
DOI
10.1097/MCP.0000000000000228
language
English
LU publication?
yes
id
ef9a7012-c185-4216-bb57-c36793931c7a (old id 8235329)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26574723?dopt=Abstract
date added to LUP
2015-12-01 13:39:56
date last changed
2017-07-09 04:32:36
@article{ef9a7012-c185-4216-bb57-c36793931c7a,
  abstract     = {In humans, mast cells are ubiquitously present in tissues adjacent to external environment and consequently have an important sentential role in host defence, homeostasis and repair. Their key role in allergen-mediated conditions has been recognized for many decades already. So far, therapies targeting mast cells offered clinical efficacy in allergic conditions except for asthma. More recently, sophisticated sampling and detection techniques revealed pleiotrophic immunological and functional properties of mast cells in and beyond asthma with potential clinical and management implications. These findings bring back the mast cell as a key player in the field of asthma and warrant a review of the recent literature.},
  author       = {Andersson, Cecilia and Tufvesson, Ellen and Diamant, Zuzana and Bjermer, Leif},
  issn         = {1531-6971},
  language     = {eng},
  number       = {1},
  pages        = {10--17},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Current Opinion in Pulmonary Medicine},
  title        = {Revisiting the role of the mast cell in asthma.},
  url          = {http://dx.doi.org/10.1097/MCP.0000000000000228},
  volume       = {22},
  year         = {2016},
}