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Extracellular matrix structure.

Theocharis, Achilleas D; Skandalis, Spyros S; Gialeli, Chrysostomi LU and Karamanos, Nikos K (2015) In Advanced Drug Delivery Reviews
Abstract
Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins, and several other glycoproteins. Matrix components bind each other as well as cell to adhesion receptors forming a complex network into which cells reside in all tissues and organs. Cell surface receptors transduce signals into cells from ECM, which regulate diverse cellular functions, such as survival, growth, migration, and differentiation and are vital for maintaining normal homeostasis. ECM is a highly dynamic structural network that continuously undergoes remodeling mediated by several matrix-degrading enzymes during normal and pathological conditions.... (More)
Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins, and several other glycoproteins. Matrix components bind each other as well as cell to adhesion receptors forming a complex network into which cells reside in all tissues and organs. Cell surface receptors transduce signals into cells from ECM, which regulate diverse cellular functions, such as survival, growth, migration, and differentiation and are vital for maintaining normal homeostasis. ECM is a highly dynamic structural network that continuously undergoes remodeling mediated by several matrix-degrading enzymes during normal and pathological conditions. Deregulation of ECM composition and structure is associated with the development and progression of several pathologic conditions. This article emphasizes in the complex ECM structure as to provide a better understanding of its dynamic structural and functional multipotency. Where relevant, the implication of the various families of ECM macromolecules in health and disease is also presented. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Advanced Drug Delivery Reviews
publisher
Elsevier
external identifiers
  • pmid:26562801
  • scopus:84957808678
  • wos:000370906200002
ISSN
0169-409X
DOI
10.1016/j.addr.2015.11.001
language
English
LU publication?
yes
id
af0c5a08-9845-48dc-8950-1e803c33e013 (old id 8235702)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26562801?dopt=Abstract
date added to LUP
2015-12-04 19:53:02
date last changed
2017-11-19 04:19:24
@article{af0c5a08-9845-48dc-8950-1e803c33e013,
  abstract     = {Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins, and several other glycoproteins. Matrix components bind each other as well as cell to adhesion receptors forming a complex network into which cells reside in all tissues and organs. Cell surface receptors transduce signals into cells from ECM, which regulate diverse cellular functions, such as survival, growth, migration, and differentiation and are vital for maintaining normal homeostasis. ECM is a highly dynamic structural network that continuously undergoes remodeling mediated by several matrix-degrading enzymes during normal and pathological conditions. Deregulation of ECM composition and structure is associated with the development and progression of several pathologic conditions. This article emphasizes in the complex ECM structure as to provide a better understanding of its dynamic structural and functional multipotency. Where relevant, the implication of the various families of ECM macromolecules in health and disease is also presented.},
  author       = {Theocharis, Achilleas D and Skandalis, Spyros S and Gialeli, Chrysostomi and Karamanos, Nikos K},
  issn         = {0169-409X},
  language     = {eng},
  month        = {11},
  publisher    = {Elsevier},
  series       = {Advanced Drug Delivery Reviews},
  title        = {Extracellular matrix structure.},
  url          = {http://dx.doi.org/10.1016/j.addr.2015.11.001},
  year         = {2015},
}