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Low ICU Admission and Excellent Outcomes in MIS-C : A Swedish Study From an Open Society

Król, Petra LU ; Altman, Maria ; Berg, Stefan ; Berntson, Lillemor ; Brodin, Petter ; Fasth, Anders ; Kahn, Robin LU ; Lingman Framme, Jenny ; Mossberg, Maria LU and Nordenhäll, Charlotta , et al. (2026) In Acta Paediatrica, International Journal of Paediatrics 115(2). p.335-344
Abstract

Aim: During the COVID-19 pandemic, Sweden chose a more open public health approach. A general concern was that this approach would affect the population negatively. We describe the Swedish national MIS-C cohort and risk factors for severe disease defined as admission to the intensive care unit and cardiogenic shock. Methods: Nationwide population-based cross-sectional study. All children and adolescents from 0 to 19 years of age with MIS-C from March 2020 to August 2022 were included. Multivariable logistic regression with ICU admission and cardiogenic shock as outcomes was used to evaluate risk factors for severe disease. Results: A total of 338 MIS-C cases were identified; 69 patients (20%) required intensive care and 38 patients... (More)

Aim: During the COVID-19 pandemic, Sweden chose a more open public health approach. A general concern was that this approach would affect the population negatively. We describe the Swedish national MIS-C cohort and risk factors for severe disease defined as admission to the intensive care unit and cardiogenic shock. Methods: Nationwide population-based cross-sectional study. All children and adolescents from 0 to 19 years of age with MIS-C from March 2020 to August 2022 were included. Multivariable logistic regression with ICU admission and cardiogenic shock as outcomes was used to evaluate risk factors for severe disease. Results: A total of 338 MIS-C cases were identified; 69 patients (20%) required intensive care and 38 patients (11%) developed cardiogenic shock. Clinical findings associated with ICU admission were cardiac involvement: OR 14.00 (6.28–34.70), airway involvement: OR 6.75 (3.23–14.80), hyperinflammation: OR 3.25 (1.34–7.97), oedema: OR 2.40 (1.07–5.44) and diarrhoea: OR 2.23 (1.07–4.80). Clinical findings associated with cardiogenic shock were hyperinflammation: OR 5.10 (2.16–12.00), airway involvement: OR 4.87 (2.12–12.00), higher age (13–19 vs. 0–5 years): OR 3.85 (1.17–15.60), obesity: OR 3.55 (1.14–10.5) and diarrhoea: OR 2.48 (1.09–5.92). Conclusion: In Swedish national MIS-C cohort, the rate of ICU admission was low and outcome excellent. Identifying risk factors for ICU admission and cardiogenic shock may facilitate early detection of risk patients.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
COVID-19, MIS-C, risk factors, severity, Sweden
in
Acta Paediatrica, International Journal of Paediatrics
volume
115
issue
2
pages
10 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:105018676751
  • pmid:41077663
ISSN
0803-5253
DOI
10.1111/apa.70329
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2025 The Author(s). Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.
id
823b47c1-bf2e-4905-ab0d-d33e223d15dd
date added to LUP
2026-01-26 09:50:30
date last changed
2026-01-27 03:00:08
@article{823b47c1-bf2e-4905-ab0d-d33e223d15dd,
  abstract     = {{<p>Aim: During the COVID-19 pandemic, Sweden chose a more open public health approach. A general concern was that this approach would affect the population negatively. We describe the Swedish national MIS-C cohort and risk factors for severe disease defined as admission to the intensive care unit and cardiogenic shock. Methods: Nationwide population-based cross-sectional study. All children and adolescents from 0 to 19 years of age with MIS-C from March 2020 to August 2022 were included. Multivariable logistic regression with ICU admission and cardiogenic shock as outcomes was used to evaluate risk factors for severe disease. Results: A total of 338 MIS-C cases were identified; 69 patients (20%) required intensive care and 38 patients (11%) developed cardiogenic shock. Clinical findings associated with ICU admission were cardiac involvement: OR 14.00 (6.28–34.70), airway involvement: OR 6.75 (3.23–14.80), hyperinflammation: OR 3.25 (1.34–7.97), oedema: OR 2.40 (1.07–5.44) and diarrhoea: OR 2.23 (1.07–4.80). Clinical findings associated with cardiogenic shock were hyperinflammation: OR 5.10 (2.16–12.00), airway involvement: OR 4.87 (2.12–12.00), higher age (13–19 vs. 0–5 years): OR 3.85 (1.17–15.60), obesity: OR 3.55 (1.14–10.5) and diarrhoea: OR 2.48 (1.09–5.92). Conclusion: In Swedish national MIS-C cohort, the rate of ICU admission was low and outcome excellent. Identifying risk factors for ICU admission and cardiogenic shock may facilitate early detection of risk patients.</p>}},
  author       = {{Król, Petra and Altman, Maria and Berg, Stefan and Berntson, Lillemor and Brodin, Petter and Fasth, Anders and Kahn, Robin and Lingman Framme, Jenny and Mossberg, Maria and Nordenhäll, Charlotta and Palmblad, Karin and Rudolph, André and Säve-Söderbergh, Eva and Horne, Anna Carin}},
  issn         = {{0803-5253}},
  keywords     = {{COVID-19; MIS-C; risk factors; severity; Sweden}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{335--344}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Paediatrica, International Journal of Paediatrics}},
  title        = {{Low ICU Admission and Excellent Outcomes in MIS-C : A Swedish Study From an Open Society}},
  url          = {{http://dx.doi.org/10.1111/apa.70329}},
  doi          = {{10.1111/apa.70329}},
  volume       = {{115}},
  year         = {{2026}},
}