IgG4 subclass glutamic acid decarboxylase antibodies (GADA) are associated with a reduced risk of developing type 1 diabetes as well as increased C-peptide levels in GADA positive gestational diabetes.
Dereke, Jonatan LU
; Nilsson, Charlotta
LU
; Strevens, Helena
LU
; Landin-Olsson, Mona
LU
and Hillman, Magnus
LU
(2016)
In Clinical Immunology
162.
p.45-48
- Abstract
- Some women with gestational diabetes (GDM) present with autoantibodies associated with type 1 diabetes. These are usually directed against glutamic acid decarboxylase (GADA) and suggested to predict development of type 1 diabetes. The primary aim of this study was to investigate if GADA IgG subclasses at onset of GDM could assist in predicting postpartum development. Of 1225 women diagnosed with first-time GDM only 51 were GADA-positive. Total GADA was determined using ELISA. GADA subclasses were determined with radioimmunoassay. Approximately 25% of GADA-positive women developed type 1 diabetes postpartum. Titers of total GADA were higher in women that developed type 1 diabetes (142.1 vs 74.2u/mL; p=0.04) and they also had lower titers of... (More)
- Some women with gestational diabetes (GDM) present with autoantibodies associated with type 1 diabetes. These are usually directed against glutamic acid decarboxylase (GADA) and suggested to predict development of type 1 diabetes. The primary aim of this study was to investigate if GADA IgG subclasses at onset of GDM could assist in predicting postpartum development. Of 1225 women diagnosed with first-time GDM only 51 were GADA-positive. Total GADA was determined using ELISA. GADA subclasses were determined with radioimmunoassay. Approximately 25% of GADA-positive women developed type 1 diabetes postpartum. Titers of total GADA were higher in women that developed type 1 diabetes (142.1 vs 74.2u/mL; p=0.04) and they also had lower titers of GADA IgG4 (index=0.01 vs 0.04; p=0.03). In conclusion we found that that women with high titers of total GADA but low titers of GADA IgG4 were more prone to develop type 1 diabetes postpartum. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8240019
- author
- Dereke, Jonatan
LU
; Nilsson, Charlotta
LU
; Strevens, Helena
LU
; Landin-Olsson, Mona
LU
and Hillman, Magnus
LU
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Clinical Immunology
- volume
- 162
- pages
- 45 - 48
- publisher
- Elsevier
- external identifiers
-
- pmid:26548838
- wos:000368970000006
- scopus:84946811180
- pmid:26548838
- ISSN
- 1521-6616
- DOI
- 10.1016/j.clim.2015.11.001
- project
- Identifiering av prediktiva faktorer för manifest diabetes och dess komplikationer vid gestationell diabetes mellitus
- language
- English
- LU publication?
- yes
- id
- ce9b13ef-bf0d-4a03-8269-d106243e7bcb (old id 8240019)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26548838?dopt=Abstract
- date added to LUP
- 2016-04-01 10:03:49
- date last changed
- 2024-01-21 04:25:14
@article{ce9b13ef-bf0d-4a03-8269-d106243e7bcb,
abstract = {{Some women with gestational diabetes (GDM) present with autoantibodies associated with type 1 diabetes. These are usually directed against glutamic acid decarboxylase (GADA) and suggested to predict development of type 1 diabetes. The primary aim of this study was to investigate if GADA IgG subclasses at onset of GDM could assist in predicting postpartum development. Of 1225 women diagnosed with first-time GDM only 51 were GADA-positive. Total GADA was determined using ELISA. GADA subclasses were determined with radioimmunoassay. Approximately 25% of GADA-positive women developed type 1 diabetes postpartum. Titers of total GADA were higher in women that developed type 1 diabetes (142.1 vs 74.2u/mL; p=0.04) and they also had lower titers of GADA IgG4 (index=0.01 vs 0.04; p=0.03). In conclusion we found that that women with high titers of total GADA but low titers of GADA IgG4 were more prone to develop type 1 diabetes postpartum.}},
author = {{Dereke, Jonatan and Nilsson, Charlotta and Strevens, Helena and Landin-Olsson, Mona and Hillman, Magnus}},
issn = {{1521-6616}},
language = {{eng}},
pages = {{45--48}},
publisher = {{Elsevier}},
series = {{Clinical Immunology}},
title = {{IgG4 subclass glutamic acid decarboxylase antibodies (GADA) are associated with a reduced risk of developing type 1 diabetes as well as increased C-peptide levels in GADA positive gestational diabetes.}},
url = {{https://lup.lub.lu.se/search/files/8064101/1524341.pdf}},
doi = {{10.1016/j.clim.2015.11.001}},
volume = {{162}},
year = {{2016}},
}