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Structural white matter properties and cognitive resilience to tau pathology

Qiu, Ting ; Liu, Zhen Qi ; Rheault, François ; Legarreta, Jon Haitz ; Valcourt Caron, Alex ; St-Onge, Frédéric ; Strikwerda-Brown, Cherie ; Metz, Amelie ; Dadar, Mahsa and Soucy, Jean Paul , et al. (2024) In Alzheimer's and Dementia
Abstract

INTRODUCTION: We assessed whether macro- and/or micro-structural white matter properties are associated with cognitive resilience to Alzheimer's disease pathology years prior to clinical onset. METHODS: We examined whether global efficiency, an indicator of communication efficiency in brain networks, and diffusion measurements within the limbic network and default mode network moderate the association between amyloid-β/tau pathology and cognitive decline. We also investigated whether demographic and health/risk factors are associated with white matter properties. RESULTS: Higher global efficiency of the limbic network, as well as free-water corrected diffusion measures within the tracts of both networks, attenuated the impact of tau... (More)

INTRODUCTION: We assessed whether macro- and/or micro-structural white matter properties are associated with cognitive resilience to Alzheimer's disease pathology years prior to clinical onset. METHODS: We examined whether global efficiency, an indicator of communication efficiency in brain networks, and diffusion measurements within the limbic network and default mode network moderate the association between amyloid-β/tau pathology and cognitive decline. We also investigated whether demographic and health/risk factors are associated with white matter properties. RESULTS: Higher global efficiency of the limbic network, as well as free-water corrected diffusion measures within the tracts of both networks, attenuated the impact of tau pathology on memory decline. Education, age, sex, white matter hyperintensities, and vascular risk factors were associated with white matter properties of both networks. DISCUSSION: White matter can influence cognitive resilience against tau pathology, and promoting education and vascular health may enhance optimal white matter properties. Highlights: Aβ and tau were associated with longitudinal memory change over ∼7.5 years. White matter properties attenuated the impact of tau pathology on memory change. Health/risk factors were associated with white matter properties.

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organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
amyloid-β, cognitive resilience, default mode network, limbic network, tau, white matter
in
Alzheimer's and Dementia
publisher
Wiley
external identifiers
  • scopus:85189642964
  • pmid:38561254
ISSN
1552-5260
DOI
10.1002/alz.13776
language
English
LU publication?
yes
id
824896f9-bc79-4f0d-9cf9-876a83a73895
date added to LUP
2024-04-26 15:27:28
date last changed
2024-06-07 19:45:18
@article{824896f9-bc79-4f0d-9cf9-876a83a73895,
  abstract     = {{<p>INTRODUCTION: We assessed whether macro- and/or micro-structural white matter properties are associated with cognitive resilience to Alzheimer's disease pathology years prior to clinical onset. METHODS: We examined whether global efficiency, an indicator of communication efficiency in brain networks, and diffusion measurements within the limbic network and default mode network moderate the association between amyloid-β/tau pathology and cognitive decline. We also investigated whether demographic and health/risk factors are associated with white matter properties. RESULTS: Higher global efficiency of the limbic network, as well as free-water corrected diffusion measures within the tracts of both networks, attenuated the impact of tau pathology on memory decline. Education, age, sex, white matter hyperintensities, and vascular risk factors were associated with white matter properties of both networks. DISCUSSION: White matter can influence cognitive resilience against tau pathology, and promoting education and vascular health may enhance optimal white matter properties. Highlights: Aβ and tau were associated with longitudinal memory change over ∼7.5 years. White matter properties attenuated the impact of tau pathology on memory change. Health/risk factors were associated with white matter properties.</p>}},
  author       = {{Qiu, Ting and Liu, Zhen Qi and Rheault, François and Legarreta, Jon Haitz and Valcourt Caron, Alex and St-Onge, Frédéric and Strikwerda-Brown, Cherie and Metz, Amelie and Dadar, Mahsa and Soucy, Jean Paul and Pichet Binette, Alexa and Spreng, R. Nathan and Descoteaux, Maxime and Villeneuve, Sylvia}},
  issn         = {{1552-5260}},
  keywords     = {{amyloid-β; cognitive resilience; default mode network; limbic network; tau; white matter}},
  language     = {{eng}},
  publisher    = {{Wiley}},
  series       = {{Alzheimer's and Dementia}},
  title        = {{Structural white matter properties and cognitive resilience to tau pathology}},
  url          = {{http://dx.doi.org/10.1002/alz.13776}},
  doi          = {{10.1002/alz.13776}},
  year         = {{2024}},
}