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The role of sulphonylurea in combination therapy assessed in a trial of sulphonylurea withdrawal. Scandinavian Insulin-Sulphonylurea Study Group Research Team

Landstedt-Hallin, L ; Arner, P ; Lins, P E ; Bolinder, J ; Olsen, H LU and Groop, L LU (1999) In Diabetic medicine : a journal of the British Diabetic Association 16(10). p.34-827
Abstract

AIMS: To evaluate the effect of adding insulin to sulphonylurea (SU) and the effect of SU withdrawal on glycaemic control in Type 2 diabetic patients who failed on treatment with SU alone.

METHOD: One hundred and seventy-five patients were included in a placebo-controlled multicentre study. During phase I (4 months), premixed insulin was added to glibenclamide therapy; during phase II (1-4 months, depending on response) the insulin dose was fixed, while placebo or glibenclamide replaced the open SU therapy. Insulin sensitivity (KITT), beta-cell function (C-peptide) and metabolic control (HbA1c) were monitored.

RESULTS: HbA1c improved from 9.65% to 7.23% (P < 0.0001) during phase I. A high HbA1c value (P < 0.0001) and a... (More)

AIMS: To evaluate the effect of adding insulin to sulphonylurea (SU) and the effect of SU withdrawal on glycaemic control in Type 2 diabetic patients who failed on treatment with SU alone.

METHOD: One hundred and seventy-five patients were included in a placebo-controlled multicentre study. During phase I (4 months), premixed insulin was added to glibenclamide therapy; during phase II (1-4 months, depending on response) the insulin dose was fixed, while placebo or glibenclamide replaced the open SU therapy. Insulin sensitivity (KITT), beta-cell function (C-peptide) and metabolic control (HbA1c) were monitored.

RESULTS: HbA1c improved from 9.65% to 7.23% (P < 0.0001) during phase I. A high HbA1c value (P < 0.0001) and a high KITT-value (P = 0.045) at baseline were associated with a beneficial response to combination treatment. During phase II, glycaemic control was unchanged in the control (glibenclamide) group. In the placebo group, after SU withdrawal, fasting blood glucose (FBG) increased by 10% or more within 4 weeks in 79% of the patients. Patients (67 of 112) with an FBG increase > or =40% during phase II were defined as 'SU responders' by protocol. In a multivariate analysis only a long duration of diabetes was associated with SU response. There were more GAD-antibody-positive patients among non-responders (18% vs. 4%, P = 0.0263).

CONCLUSIONS: Poor glycaemic control in combination with preserved insulin sensitivity and lack of GAD antibodies predicts a beneficial response to combination therapy, which can be achieved in 75% of patients with SU failure.

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Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Aged, Blood Glucose/metabolism, Diabetes Mellitus, Type 2/blood, Drug Therapy, Combination, Female, Glyburide/administration & dosage, Glycated Hemoglobin A/analysis, Humans, Hypoglycemic Agents/administration & dosage, Insulin/administration & dosage, Male, Middle Aged, Multivariate Analysis, Placebos, Sulfonylurea Compounds/administration & dosage
in
Diabetic medicine : a journal of the British Diabetic Association
volume
16
issue
10
pages
8 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:10547209
  • scopus:0032706321
ISSN
0742-3071
DOI
10.1046/j.1464-5491.1999.00171.x
language
English
LU publication?
no
id
8254536a-110c-48f7-b64e-b3769df50885
date added to LUP
2019-05-29 09:18:37
date last changed
2019-10-29 05:51:10
@article{8254536a-110c-48f7-b64e-b3769df50885,
  abstract     = {<p>AIMS: To evaluate the effect of adding insulin to sulphonylurea (SU) and the effect of SU withdrawal on glycaemic control in Type 2 diabetic patients who failed on treatment with SU alone.</p><p>METHOD: One hundred and seventy-five patients were included in a placebo-controlled multicentre study. During phase I (4 months), premixed insulin was added to glibenclamide therapy; during phase II (1-4 months, depending on response) the insulin dose was fixed, while placebo or glibenclamide replaced the open SU therapy. Insulin sensitivity (KITT), beta-cell function (C-peptide) and metabolic control (HbA1c) were monitored.</p><p>RESULTS: HbA1c improved from 9.65% to 7.23% (P &lt; 0.0001) during phase I. A high HbA1c value (P &lt; 0.0001) and a high KITT-value (P = 0.045) at baseline were associated with a beneficial response to combination treatment. During phase II, glycaemic control was unchanged in the control (glibenclamide) group. In the placebo group, after SU withdrawal, fasting blood glucose (FBG) increased by 10% or more within 4 weeks in 79% of the patients. Patients (67 of 112) with an FBG increase &gt; or =40% during phase II were defined as 'SU responders' by protocol. In a multivariate analysis only a long duration of diabetes was associated with SU response. There were more GAD-antibody-positive patients among non-responders (18% vs. 4%, P = 0.0263).</p><p>CONCLUSIONS: Poor glycaemic control in combination with preserved insulin sensitivity and lack of GAD antibodies predicts a beneficial response to combination therapy, which can be achieved in 75% of patients with SU failure.</p>},
  author       = {Landstedt-Hallin, L and Arner, P and Lins, P E and Bolinder, J and Olsen, H and Groop, L},
  issn         = {0742-3071},
  language     = {eng},
  number       = {10},
  pages        = {34--827},
  publisher    = {Wiley-Blackwell},
  series       = {Diabetic medicine : a journal of the British Diabetic Association},
  title        = {The role of sulphonylurea in combination therapy assessed in a trial of sulphonylurea withdrawal. Scandinavian Insulin-Sulphonylurea Study Group Research Team},
  url          = {http://dx.doi.org/10.1046/j.1464-5491.1999.00171.x},
  doi          = {10.1046/j.1464-5491.1999.00171.x},
  volume       = {16},
  year         = {1999},
}