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Photovoltaic nanowires affect human lung cell proliferation under illumination conditions

Olsson, Therese B LU ; Abariute, Laura LU ; Hrachowina, Lukas LU ; Barrigón, Enrique LU ; Volpati, Diogo LU ; Limpert, Steven LU orcid ; Otnes, Gaute LU ; Borgström, Magnus T LU and Prinz, Christelle N LU (2020) In Nanoscale 12. p.14237-14244
Abstract

Using light to interact with cells is a promising way to steer cell behavior with minimal perturbation. Besides optogenetics, photovoltaic nanostructures such as nanowires can be used to interact with cells using light as a switch. Photovoltaic nanowires have, for instance, been used to stimulate neurons. However, the effects of the photovoltaic activity on cells are still poorly understood and characterized. Here, we investigate the effects of the photovoltaic activity of p-i-n nanowire arrays on A549 human lung adenocarcinoma cells. We have cultured A549 cells on top of vertical arrays of indium phosphide p-i-n nanowires (photovoltaic nanowires), with and without illumination to assess the effects of the nanowire photovoltaic activity... (More)

Using light to interact with cells is a promising way to steer cell behavior with minimal perturbation. Besides optogenetics, photovoltaic nanostructures such as nanowires can be used to interact with cells using light as a switch. Photovoltaic nanowires have, for instance, been used to stimulate neurons. However, the effects of the photovoltaic activity on cells are still poorly understood and characterized. Here, we investigate the effects of the photovoltaic activity of p-i-n nanowire arrays on A549 human lung adenocarcinoma cells. We have cultured A549 cells on top of vertical arrays of indium phosphide p-i-n nanowires (photovoltaic nanowires), with and without illumination to assess the effects of the nanowire photovoltaic activity on cells. We show that there is a higher proportion of dormant cells when the p-i-n nanowire arrays are illuminated. However, there is no difference in the proportion of dormant cells when the p-i-n nanowires are coated with oxide, which suggests that carrier injection in the cell medium (in this case, the release of electrons from the tip of the nanowires) is an important factor for modulating cell proliferation on photovoltaic nanowires. The results open up for interesting applications of photovoltaic nanowires in biomedicine, such as using them as a dormancy switch.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nanoscale
volume
12
pages
8 pages
publisher
Royal Society of Chemistry
external identifiers
  • pmid:32608415
  • scopus:85088485515
ISSN
2040-3372
DOI
10.1039/c9nr07678f
language
English
LU publication?
yes
id
827e5141-2ac8-42c1-909f-552a232fef9a
date added to LUP
2020-07-06 08:55:48
date last changed
2024-04-03 09:58:20
@article{827e5141-2ac8-42c1-909f-552a232fef9a,
  abstract     = {{<p>Using light to interact with cells is a promising way to steer cell behavior with minimal perturbation. Besides optogenetics, photovoltaic nanostructures such as nanowires can be used to interact with cells using light as a switch. Photovoltaic nanowires have, for instance, been used to stimulate neurons. However, the effects of the photovoltaic activity on cells are still poorly understood and characterized. Here, we investigate the effects of the photovoltaic activity of p-i-n nanowire arrays on A549 human lung adenocarcinoma cells. We have cultured A549 cells on top of vertical arrays of indium phosphide p-i-n nanowires (photovoltaic nanowires), with and without illumination to assess the effects of the nanowire photovoltaic activity on cells. We show that there is a higher proportion of dormant cells when the p-i-n nanowire arrays are illuminated. However, there is no difference in the proportion of dormant cells when the p-i-n nanowires are coated with oxide, which suggests that carrier injection in the cell medium (in this case, the release of electrons from the tip of the nanowires) is an important factor for modulating cell proliferation on photovoltaic nanowires. The results open up for interesting applications of photovoltaic nanowires in biomedicine, such as using them as a dormancy switch.</p>}},
  author       = {{Olsson, Therese B and Abariute, Laura and Hrachowina, Lukas and Barrigón, Enrique and Volpati, Diogo and Limpert, Steven and Otnes, Gaute and Borgström, Magnus T and Prinz, Christelle N}},
  issn         = {{2040-3372}},
  language     = {{eng}},
  pages        = {{14237--14244}},
  publisher    = {{Royal Society of Chemistry}},
  series       = {{Nanoscale}},
  title        = {{Photovoltaic nanowires affect human lung cell proliferation under illumination conditions}},
  url          = {{http://dx.doi.org/10.1039/c9nr07678f}},
  doi          = {{10.1039/c9nr07678f}},
  volume       = {{12}},
  year         = {{2020}},
}