Development of supersensitivity to methacholine in the rat detrusor following either parasympathetic denervation or decentralization
(1984) In Acta Physiologica Scandinavica 122(2). p.175-179- Abstract
- The male rat urinary bladder belongs to those few structures where both the post- and preganglionic parasympathetic nerves are accessible for severance. In the present study the sensitivity to the parasympathomimetic drug methacholine of muscle strips of either denervated or decentralized bladders was examined in vitro. One week postoperatively denervated and decentralized bladders were sensitized to the same degree, the ED50 values being 4 times less than ED50 of unoperated control bladders. In contrast to the decentralized bladders the supersensitivity in the denervated ones was found to have increased further when tested four weeks postoperatively, the ED50 value being about 20 times less than that of controls. The present findings are... (More)
- The male rat urinary bladder belongs to those few structures where both the post- and preganglionic parasympathetic nerves are accessible for severance. In the present study the sensitivity to the parasympathomimetic drug methacholine of muscle strips of either denervated or decentralized bladders was examined in vitro. One week postoperatively denervated and decentralized bladders were sensitized to the same degree, the ED50 values being 4 times less than ED50 of unoperated control bladders. In contrast to the decentralized bladders the supersensitivity in the denervated ones was found to have increased further when tested four weeks postoperatively, the ED50 value being about 20 times less than that of controls. The present findings are in agreement with Cannon's "law of denervation". The results are discussed in relation to possible mechanisms behind the phenomenon of supersensitivity. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1103265
- author
- Ekström, J and Malmberg, Lars LU
- organization
- publishing date
- 1984
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Physiologica Scandinavica
- volume
- 122
- issue
- 2
- pages
- 175 - 179
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:6393713
- scopus:0021719451
- ISSN
- 0001-6772
- language
- English
- LU publication?
- yes
- id
- 8284c84c-4db2-483c-8db7-d3955f9a6934 (old id 1103265)
- date added to LUP
- 2016-04-01 17:06:18
- date last changed
- 2025-04-04 14:10:19
@article{8284c84c-4db2-483c-8db7-d3955f9a6934,
abstract = {{The male rat urinary bladder belongs to those few structures where both the post- and preganglionic parasympathetic nerves are accessible for severance. In the present study the sensitivity to the parasympathomimetic drug methacholine of muscle strips of either denervated or decentralized bladders was examined in vitro. One week postoperatively denervated and decentralized bladders were sensitized to the same degree, the ED50 values being 4 times less than ED50 of unoperated control bladders. In contrast to the decentralized bladders the supersensitivity in the denervated ones was found to have increased further when tested four weeks postoperatively, the ED50 value being about 20 times less than that of controls. The present findings are in agreement with Cannon's "law of denervation". The results are discussed in relation to possible mechanisms behind the phenomenon of supersensitivity.}},
author = {{Ekström, J and Malmberg, Lars}},
issn = {{0001-6772}},
language = {{eng}},
number = {{2}},
pages = {{175--179}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Physiologica Scandinavica}},
title = {{Development of supersensitivity to methacholine in the rat detrusor following either parasympathetic denervation or decentralization}},
volume = {{122}},
year = {{1984}},
}