ECoG activity distribution patterns detects global cortical responses following weak tactile inputs
(2024) In iScience 27(4).- Abstract
Many studies have suggested that the neocortex operates as a global network of functionally interconnected neurons, indicating that any sensory input could shift activity distributions across the whole brain. A tool assessing the activity distribution across cortical regions with high temporal resolution could then potentially detect subtle changes that may pass unnoticed in regionalized analyses. We used eight-channel, distributed electrocorticogram (ECoG) recordings to analyze changes in global activity distribution caused by single pulse electrical stimulations of the paw. We analyzed the temporally evolving patterns of the activity distributions using principal component analysis (PCA). We found that the localized tactile... (More)
Many studies have suggested that the neocortex operates as a global network of functionally interconnected neurons, indicating that any sensory input could shift activity distributions across the whole brain. A tool assessing the activity distribution across cortical regions with high temporal resolution could then potentially detect subtle changes that may pass unnoticed in regionalized analyses. We used eight-channel, distributed electrocorticogram (ECoG) recordings to analyze changes in global activity distribution caused by single pulse electrical stimulations of the paw. We analyzed the temporally evolving patterns of the activity distributions using principal component analysis (PCA). We found that the localized tactile stimulation caused clearly measurable changes in global ECoG activity distribution. These changes in signal activity distribution patterns were detectable across a small number of ECoG channels, even when excluding the somatosensory cortex, suggesting that the method has high sensitivity, potentially making it applicable to human electroencephalography (EEG) for detection of pathological changes.
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- author
- Mellbin, Astrid LU ; Rongala, Udaya LU ; Jörntell, Henrik LU and Bengtsson, Fredrik LU
- organization
- publishing date
- 2024-04-19
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cognitive neuroscience, Neuroscience, Sensory neuroscience
- in
- iScience
- volume
- 27
- issue
- 4
- article number
- 109338
- publisher
- Elsevier
- external identifiers
-
- pmid:38495818
- scopus:85187002553
- ISSN
- 2589-0042
- DOI
- 10.1016/j.isci.2024.109338
- language
- English
- LU publication?
- yes
- id
- 82ecc157-e70d-4f17-a74d-919ea2fc5b95
- date added to LUP
- 2024-04-03 08:39:36
- date last changed
- 2024-04-17 10:47:39
@article{82ecc157-e70d-4f17-a74d-919ea2fc5b95,
abstract = {{<p>Many studies have suggested that the neocortex operates as a global network of functionally interconnected neurons, indicating that any sensory input could shift activity distributions across the whole brain. A tool assessing the activity distribution across cortical regions with high temporal resolution could then potentially detect subtle changes that may pass unnoticed in regionalized analyses. We used eight-channel, distributed electrocorticogram (ECoG) recordings to analyze changes in global activity distribution caused by single pulse electrical stimulations of the paw. We analyzed the temporally evolving patterns of the activity distributions using principal component analysis (PCA). We found that the localized tactile stimulation caused clearly measurable changes in global ECoG activity distribution. These changes in signal activity distribution patterns were detectable across a small number of ECoG channels, even when excluding the somatosensory cortex, suggesting that the method has high sensitivity, potentially making it applicable to human electroencephalography (EEG) for detection of pathological changes.</p>}},
author = {{Mellbin, Astrid and Rongala, Udaya and Jörntell, Henrik and Bengtsson, Fredrik}},
issn = {{2589-0042}},
keywords = {{Cognitive neuroscience; Neuroscience; Sensory neuroscience}},
language = {{eng}},
month = {{04}},
number = {{4}},
publisher = {{Elsevier}},
series = {{iScience}},
title = {{ECoG activity distribution patterns detects global cortical responses following weak tactile inputs}},
url = {{http://dx.doi.org/10.1016/j.isci.2024.109338}},
doi = {{10.1016/j.isci.2024.109338}},
volume = {{27}},
year = {{2024}},
}