Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

von Willebrand Factor D and EGF Domains is an evolutionarily conserved and required feature of blastemas capable of multi-tissue appendage regeneration

Leigh, N.D. LU orcid ; Sessa, S. ; Dragalzew, A.C. ; Payzin-Dogru, D. ; Sousa, J.F. ; Aggouras, A.N. ; Johnson, K. ; Dunlap, G.S. ; Haas, B.J. and Levin, M. , et al. (2019)
Abstract
Regenerative ability varies tremendously across species. A common feature of regeneration of appendages such as limbs, fins, antlers, and tails is the formation of a blastema--a transient structure that houses a pool of progenitor cells that regenerate the missing tissue. We have identified the expression of von Willebrand Factor D and EGF Domains (vwde) as a common feature of blastemas capable of regenerating limbs and fins in a variety of highly regenerative species. Further, vwde expression is tightly linked to the ability to regenerate appendages. Functional experiments demonstrate a requirement for vwde in regeneration and indicate that Vwde is a potent mitogen in the blastema. These data identify a key role for vwde in regenerating... (More)
Regenerative ability varies tremendously across species. A common feature of regeneration of appendages such as limbs, fins, antlers, and tails is the formation of a blastema--a transient structure that houses a pool of progenitor cells that regenerate the missing tissue. We have identified the expression of von Willebrand Factor D and EGF Domains (vwde) as a common feature of blastemas capable of regenerating limbs and fins in a variety of highly regenerative species. Further, vwde expression is tightly linked to the ability to regenerate appendages. Functional experiments demonstrate a requirement for vwde in regeneration and indicate that Vwde is a potent mitogen in the blastema. These data identify a key role for vwde in regenerating blastemas and underscore the power of an evolutionarily-informed approach for identifying conserved genetic components of regeneration. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; and (Less)
publishing date
type
Working paper/Preprint
publication status
published
publisher
bioRxiv
DOI
10.1101/842948
language
English
LU publication?
no
id
82f98236-1775-4045-9237-c4781c44685e
date added to LUP
2025-10-30 10:40:57
date last changed
2025-10-30 10:43:27
@misc{82f98236-1775-4045-9237-c4781c44685e,
  abstract     = {{Regenerative ability varies tremendously across species. A common feature of regeneration of appendages such as limbs, fins, antlers, and tails is the formation of a blastema--a transient structure that houses a pool of progenitor cells that regenerate the missing tissue. We have identified the expression of von Willebrand Factor D and EGF Domains (vwde) as a common feature of blastemas capable of regenerating limbs and fins in a variety of highly regenerative species. Further, vwde expression is tightly linked to the ability to regenerate appendages. Functional experiments demonstrate a requirement for vwde in regeneration and indicate that Vwde is a potent mitogen in the blastema. These data identify a key role for vwde in regenerating blastemas and underscore the power of an evolutionarily-informed approach for identifying conserved genetic components of regeneration.}},
  author       = {{Leigh, N.D. and Sessa, S. and Dragalzew, A.C. and Payzin-Dogru, D. and Sousa, J.F. and Aggouras, A.N. and Johnson, K. and Dunlap, G.S. and Haas, B.J. and Levin, M. and Schneider, I. and Whited, J.L.}},
  language     = {{eng}},
  month        = {{11}},
  note         = {{Preprint}},
  publisher    = {{bioRxiv}},
  title        = {{von Willebrand Factor D and EGF Domains is an evolutionarily conserved and required feature of blastemas capable of multi-tissue appendage regeneration}},
  url          = {{http://dx.doi.org/10.1101/842948}},
  doi          = {{10.1101/842948}},
  year         = {{2019}},
}