Infant Body Composition and Adipokine Concentrations in Relation to Maternal Gestational Weight Gain.
(2014) In Diabetes Care 37(5). p.1432-1438- Abstract
- OBJECTIVETo investigate associations of maternal gestational weight gain and body composition and their impact on offspring body composition and adipocytokine, glucose, and insulin concentrations at age 4 months.RESEARCH DESIGN AND METHODSThis was a prospective study including 31 mother-infant pairs (N = 62). Maternal body composition was assessed using doubly labeled water. Infant body composition was assessed at 4 months using air displacement plethysmography, and venous blood was assayed for glucose, insulin, adiponectin, interleukin-6 (IL-6), and leptin concentrations.RESULTSRate of gestational weight gain in midpregnancy was significantly associated with infant fat mass (r = 0.41, P = 0.03); rate of gestational weight in late... (More)
- OBJECTIVETo investigate associations of maternal gestational weight gain and body composition and their impact on offspring body composition and adipocytokine, glucose, and insulin concentrations at age 4 months.RESEARCH DESIGN AND METHODSThis was a prospective study including 31 mother-infant pairs (N = 62). Maternal body composition was assessed using doubly labeled water. Infant body composition was assessed at 4 months using air displacement plethysmography, and venous blood was assayed for glucose, insulin, adiponectin, interleukin-6 (IL-6), and leptin concentrations.RESULTSRate of gestational weight gain in midpregnancy was significantly associated with infant fat mass (r = 0.41, P = 0.03); rate of gestational weight in late pregnancy was significantly associated with infant fat-free mass (r = 0.37, P = 0.04). Infant birth weight was also strongly correlated with infant fat-free mass at 4 months (r = 0.63, P = 0.0002). Maternal BMI and maternal fat mass were strongly inversely associated with infant IL-6 concentrations (r = -0.60, P = 0.002 and r = -0.52, P = 0.01, respectively). Infant fat-free mass was inversely related to infant adiponectin concentrations (r = -0.48, P = 0.008) and positively correlated with infant blood glucose adjusted for insulin concentrations (r = 0.42, P = 0.04). No significant associations for leptin were observed.CONCLUSIONSTiming of maternal weight gain differentially impacts body composition of the 4-month-old infant, which in turn appears to affect the infant's glucose and adipokine concentrations. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4383334
- author
- Estampador, Angela LU ; Pomeroy, Jeremy ; Renström, Frida LU ; Nelson, Scott M ; Mogren, Ingrid ; Persson, Margareta ; Sattar, Naveed ; Domellöf, Magnus and Franks, Paul LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes Care
- volume
- 37
- issue
- 5
- pages
- 1432 - 1438
- publisher
- American Diabetes Association
- external identifiers
-
- pmid:24623025
- wos:000334840100060
- scopus:84899104203
- pmid:24623025
- ISSN
- 1935-5548
- DOI
- 10.2337/dc13-2265
- language
- English
- LU publication?
- yes
- id
- 8307551a-f899-436b-9063-b84e4aa0f173 (old id 4383334)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24623025?dopt=Abstract
- date added to LUP
- 2016-04-01 11:17:05
- date last changed
- 2022-02-03 01:11:45
@article{8307551a-f899-436b-9063-b84e4aa0f173,
abstract = {{OBJECTIVETo investigate associations of maternal gestational weight gain and body composition and their impact on offspring body composition and adipocytokine, glucose, and insulin concentrations at age 4 months.RESEARCH DESIGN AND METHODSThis was a prospective study including 31 mother-infant pairs (N = 62). Maternal body composition was assessed using doubly labeled water. Infant body composition was assessed at 4 months using air displacement plethysmography, and venous blood was assayed for glucose, insulin, adiponectin, interleukin-6 (IL-6), and leptin concentrations.RESULTSRate of gestational weight gain in midpregnancy was significantly associated with infant fat mass (r = 0.41, P = 0.03); rate of gestational weight in late pregnancy was significantly associated with infant fat-free mass (r = 0.37, P = 0.04). Infant birth weight was also strongly correlated with infant fat-free mass at 4 months (r = 0.63, P = 0.0002). Maternal BMI and maternal fat mass were strongly inversely associated with infant IL-6 concentrations (r = -0.60, P = 0.002 and r = -0.52, P = 0.01, respectively). Infant fat-free mass was inversely related to infant adiponectin concentrations (r = -0.48, P = 0.008) and positively correlated with infant blood glucose adjusted for insulin concentrations (r = 0.42, P = 0.04). No significant associations for leptin were observed.CONCLUSIONSTiming of maternal weight gain differentially impacts body composition of the 4-month-old infant, which in turn appears to affect the infant's glucose and adipokine concentrations.}},
author = {{Estampador, Angela and Pomeroy, Jeremy and Renström, Frida and Nelson, Scott M and Mogren, Ingrid and Persson, Margareta and Sattar, Naveed and Domellöf, Magnus and Franks, Paul}},
issn = {{1935-5548}},
language = {{eng}},
number = {{5}},
pages = {{1432--1438}},
publisher = {{American Diabetes Association}},
series = {{Diabetes Care}},
title = {{Infant Body Composition and Adipokine Concentrations in Relation to Maternal Gestational Weight Gain.}},
url = {{http://dx.doi.org/10.2337/dc13-2265}},
doi = {{10.2337/dc13-2265}},
volume = {{37}},
year = {{2014}},
}