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Current problems and future directions of transfusion-induced alloimmunization : summary of an NHLBI working group

Zimring, James C; Welniak, Lis; Semple, John W LU ; Ness, Paul M; Slichter, Sherrill J; Spitalnik, Steven L and , (2011) In Transfusion 51(2). p.41-435
Abstract

In April 2010, a working group sponsored by the National Heart, Lung, and Blood Institute was assembled to identify research strategies to improve our understanding of alloimmunization caused by the transfusion of allogeneic blood components and to evaluate potential approaches to both reduce its occurrence and manage its effects. Significant sequelae of alloimmunization were discussed and identified, including difficulties in maintaining chronic transfusion of red blood cells and platelets, hemolytic disease of the newborn, neonatal alloimmune thrombocytopenia, and rejection of transplanted cells and tissues. The discussions resulted in a consensus that identified key areas of future research and developmental areas, including genetic... (More)

In April 2010, a working group sponsored by the National Heart, Lung, and Blood Institute was assembled to identify research strategies to improve our understanding of alloimmunization caused by the transfusion of allogeneic blood components and to evaluate potential approaches to both reduce its occurrence and manage its effects. Significant sequelae of alloimmunization were discussed and identified, including difficulties in maintaining chronic transfusion of red blood cells and platelets, hemolytic disease of the newborn, neonatal alloimmune thrombocytopenia, and rejection of transplanted cells and tissues. The discussions resulted in a consensus that identified key areas of future research and developmental areas, including genetic and epigenetic recipient factors that regulate alloimmunization, biochemical specifics of transfused products that affect alloimmunization, and novel technologies for high-throughput genotyping to facilitate extensive and efficient antigen matching between donor and recipient. Additional areas of importance included analysis of unappreciated medical sequelae of alloimmunization, such as cellular immunity and its effect upon transplant and autoimmunity. In addition, support for research infrastructure was discussed, with an emphasis on encouraging collaboration and synergy of animal models biology and human clinical research. Finally, training future investigators was identified as an area of importance. In aggregate, this communication provides a synopsis of the opinions of the working group on the above issues and presents both a list of suggested priorities and the rationale for the topics of focus. The areas of research identified in this report represent potential fertile ground for the medical advancement of preventing and managing alloimmunization in its different forms and mitigating the clinical problems it presents to multiple patient populations.

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published
keywords
Adult, Animals, Antigens, Human Platelet, Blood Group Antigens, Blood Group Incompatibility, Blood Transfusion, Cooperative Behavior, Female, Forecasting, Health Priorities, Humans, Infant, Newborn, Isoantibodies, Lymphocyte Subsets, Male, Models, Animal, National Heart, Lung, and Blood Institute (U.S.), Pregnancy, Research Personnel, Thrombocytopenia, Neonatal Alloimmune, Transplantation Immunology, United States, Consensus Development Conference, NIH, Guideline, Journal Article, Research Support, N.I.H., Extramural
in
Transfusion
volume
51
issue
2
pages
7 pages
publisher
Wiley-Blackwell
external identifiers
  • Scopus:79951673833
ISSN
1537-2995
DOI
10.1111/j.1537-2995.2010.03024.x
language
English
LU publication?
no
id
83080942-08e8-43e9-9e1d-4fe8e75d9c3b
date added to LUP
2016-09-23 12:05:09
date last changed
2017-01-08 05:59:29
@article{83080942-08e8-43e9-9e1d-4fe8e75d9c3b,
  abstract     = {<p>In April 2010, a working group sponsored by the National Heart, Lung, and Blood Institute was assembled to identify research strategies to improve our understanding of alloimmunization caused by the transfusion of allogeneic blood components and to evaluate potential approaches to both reduce its occurrence and manage its effects. Significant sequelae of alloimmunization were discussed and identified, including difficulties in maintaining chronic transfusion of red blood cells and platelets, hemolytic disease of the newborn, neonatal alloimmune thrombocytopenia, and rejection of transplanted cells and tissues. The discussions resulted in a consensus that identified key areas of future research and developmental areas, including genetic and epigenetic recipient factors that regulate alloimmunization, biochemical specifics of transfused products that affect alloimmunization, and novel technologies for high-throughput genotyping to facilitate extensive and efficient antigen matching between donor and recipient. Additional areas of importance included analysis of unappreciated medical sequelae of alloimmunization, such as cellular immunity and its effect upon transplant and autoimmunity. In addition, support for research infrastructure was discussed, with an emphasis on encouraging collaboration and synergy of animal models biology and human clinical research. Finally, training future investigators was identified as an area of importance. In aggregate, this communication provides a synopsis of the opinions of the working group on the above issues and presents both a list of suggested priorities and the rationale for the topics of focus. The areas of research identified in this report represent potential fertile ground for the medical advancement of preventing and managing alloimmunization in its different forms and mitigating the clinical problems it presents to multiple patient populations.</p>},
  author       = {Zimring, James C and Welniak, Lis and Semple, John W and Ness, Paul M and Slichter, Sherrill J and Spitalnik, Steven L and , },
  issn         = {1537-2995},
  keyword      = {Adult,Animals,Antigens, Human Platelet,Blood Group Antigens,Blood Group Incompatibility,Blood Transfusion,Cooperative Behavior,Female,Forecasting,Health Priorities,Humans,Infant, Newborn,Isoantibodies,Lymphocyte Subsets,Male,Models, Animal,National Heart, Lung, and Blood Institute (U.S.),Pregnancy,Research Personnel,Thrombocytopenia, Neonatal Alloimmune,Transplantation Immunology,United States,Consensus Development Conference, NIH,Guideline,Journal Article,Research Support, N.I.H., Extramural},
  language     = {eng},
  number       = {2},
  pages        = {41--435},
  publisher    = {Wiley-Blackwell},
  series       = {Transfusion},
  title        = {Current problems and future directions of transfusion-induced alloimmunization : summary of an NHLBI working group},
  url          = {http://dx.doi.org/10.1111/j.1537-2995.2010.03024.x},
  volume       = {51},
  year         = {2011},
}