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Expression of Meis and Pbx genes and their protein products in the developing telencephalon : Implications for regional differentiation

Toresson, Håkan LU ; Parmar, Malin LU and Campbell, Kenneth LU (2000) In Mechanisms of Development 94(1-2). p.183-187
Abstract

The Meis and Pbx genes encode for homeodomain proteins of the TALE class and have been shown to act as co-factors for other homeodomain transcription factors (Mann and Affolter, 1998. Curr. Opin. Genet. Dev. 8, 423-429). We have studied the expression of these genes in the mouse telencephalon and found that Meis1 and Meis2 display region-specific patterns of expression from embryonic day (E)10.5 until birth, defining distinct subterritories in the developing telencephalon. The expression of the Meis genes and their proteins is highest in the subventricular zone (SVZ) and mantle regions of the ventral telencephalon. Compared to the Meis genes, Pbx genes show a broader expression within the telencephalon. However, as is the case in... (More)

The Meis and Pbx genes encode for homeodomain proteins of the TALE class and have been shown to act as co-factors for other homeodomain transcription factors (Mann and Affolter, 1998. Curr. Opin. Genet. Dev. 8, 423-429). We have studied the expression of these genes in the mouse telencephalon and found that Meis1 and Meis2 display region-specific patterns of expression from embryonic day (E)10.5 until birth, defining distinct subterritories in the developing telencephalon. The expression of the Meis genes and their proteins is highest in the subventricular zone (SVZ) and mantle regions of the ventral telencephalon. Compared to the Meis genes, Pbx genes show a broader expression within the telencephalon. However, as is the case in Drosophila (Rieckhof et al., 1997. Cell 91, 171-183; Kurrant et al., 1998. Development 125, 1037-1048; Pai et al., 1998. Genes Dev. 12, 435-446), nuclear localized PBX proteins were found to correlate highly with Meis expression. In addition, DLX proteins co-localize with nuclear PBX in distinct regions of the ventral telencephalon. (C) 2000 Elsevier Science Ireland Ltd. (C) 2000 Elsevier Science Ireland Ltd.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
DLX, Ganglionic eminence, MEIS, Mouse, PBX, Telencephalon
in
Mechanisms of Development
volume
94
issue
1-2
pages
5 pages
publisher
Elsevier
external identifiers
  • pmid:10842069
  • scopus:0034212359
ISSN
0925-4773
DOI
10.1016/S0925-4773(00)00324-5
language
English
LU publication?
yes
id
831ed938-0077-4e9e-b327-9cded1579738
date added to LUP
2019-12-12 13:49:04
date last changed
2021-08-18 01:29:44
@article{831ed938-0077-4e9e-b327-9cded1579738,
  abstract     = {<p>The Meis and Pbx genes encode for homeodomain proteins of the TALE class and have been shown to act as co-factors for other homeodomain transcription factors (Mann and Affolter, 1998. Curr. Opin. Genet. Dev. 8, 423-429). We have studied the expression of these genes in the mouse telencephalon and found that Meis1 and Meis2 display region-specific patterns of expression from embryonic day (E)10.5 until birth, defining distinct subterritories in the developing telencephalon. The expression of the Meis genes and their proteins is highest in the subventricular zone (SVZ) and mantle regions of the ventral telencephalon. Compared to the Meis genes, Pbx genes show a broader expression within the telencephalon. However, as is the case in Drosophila (Rieckhof et al., 1997. Cell 91, 171-183; Kurrant et al., 1998. Development 125, 1037-1048; Pai et al., 1998. Genes Dev. 12, 435-446), nuclear localized PBX proteins were found to correlate highly with Meis expression. In addition, DLX proteins co-localize with nuclear PBX in distinct regions of the ventral telencephalon. (C) 2000 Elsevier Science Ireland Ltd. (C) 2000 Elsevier Science Ireland Ltd.</p>},
  author       = {Toresson, Håkan and Parmar, Malin and Campbell, Kenneth},
  issn         = {0925-4773},
  language     = {eng},
  month        = {06},
  number       = {1-2},
  pages        = {183--187},
  publisher    = {Elsevier},
  series       = {Mechanisms of Development},
  title        = {Expression of Meis and Pbx genes and their protein products in the developing telencephalon : Implications for regional differentiation},
  url          = {http://dx.doi.org/10.1016/S0925-4773(00)00324-5},
  doi          = {10.1016/S0925-4773(00)00324-5},
  volume       = {94},
  year         = {2000},
}