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Characterization and Efficacy of a Nanomedical Radiopharmaceutical for Cancer Treatment

Yao Mattisson, Ingrid LU ; Bäckström, Sania LU ; Ekengard, Erik LU ; Lekmeechai, Sujinna LU ; Liu, Yi-Chi LU ; Paris, Juraj ; Petoral, Rodrigo ; Sydoff, Marie LU ; Hansen, Mats and Axelsson, Oskar (2023) In ACS Omega 8(2). p.2357-2366
Abstract

Although much progress has been made over the last decades, there is still a significant clinical need for novel therapies to manage cancer. Typical problems are that solid tumors are frequently inaccessible, aggressive, and metastatic. To contribute to solving some of these issues, we have developed a novel radioisotope-labeled 27 nm nanoparticle, 177Lu-SN201, to selectively target solid tumors via the enhanced permeability and retention effect, allowing irradiation intratumorally. We show that 177Lu-SN201 has robust stealth properties in vitro and anti-tumor efficacy in mouse mammary gland and colon carcinoma models. The possible clinical application is also addressed with single photon emission computed tomography imaging, which... (More)

Although much progress has been made over the last decades, there is still a significant clinical need for novel therapies to manage cancer. Typical problems are that solid tumors are frequently inaccessible, aggressive, and metastatic. To contribute to solving some of these issues, we have developed a novel radioisotope-labeled 27 nm nanoparticle, 177Lu-SN201, to selectively target solid tumors via the enhanced permeability and retention effect, allowing irradiation intratumorally. We show that 177Lu-SN201 has robust stealth properties in vitro and anti-tumor efficacy in mouse mammary gland and colon carcinoma models. The possible clinical application is also addressed with single photon emission computed tomography imaging, which confirms uptake in the tumor, with an average activity of 19.4% injected dose per gram (ID/g). The properties of 177Lu-SN201 make it a promising new agent for radionuclide therapy with the potential to target several solid tumor types.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
ACS Omega
volume
8
issue
2
pages
2357 - 2366
publisher
The American Chemical Society (ACS)
external identifiers
  • pmid:36687034
  • scopus:85195273587
ISSN
2470-1343
DOI
10.1021/acsomega.2c06755
language
English
LU publication?
yes
additional info
© 2023 The Authors. Published by American Chemical Society.
id
833c4c8a-8d58-4d13-9108-db20f3a9e532
date added to LUP
2026-03-23 12:06:36
date last changed
2026-06-16 12:02:10
@article{833c4c8a-8d58-4d13-9108-db20f3a9e532,
  abstract     = {{<p>Although much progress has been made over the last decades, there is still a significant clinical need for novel therapies to manage cancer. Typical problems are that solid tumors are frequently inaccessible, aggressive, and metastatic. To contribute to solving some of these issues, we have developed a novel radioisotope-labeled 27 nm nanoparticle, 177Lu-SN201, to selectively target solid tumors via the enhanced permeability and retention effect, allowing irradiation intratumorally. We show that 177Lu-SN201 has robust stealth properties in vitro and anti-tumor efficacy in mouse mammary gland and colon carcinoma models. The possible clinical application is also addressed with single photon emission computed tomography imaging, which confirms uptake in the tumor, with an average activity of 19.4% injected dose per gram (ID/g). The properties of 177Lu-SN201 make it a promising new agent for radionuclide therapy with the potential to target several solid tumor types.</p>}},
  author       = {{Yao Mattisson, Ingrid and Bäckström, Sania and Ekengard, Erik and Lekmeechai, Sujinna and Liu, Yi-Chi and Paris, Juraj and Petoral, Rodrigo and Sydoff, Marie and Hansen, Mats and Axelsson, Oskar}},
  issn         = {{2470-1343}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{2}},
  pages        = {{2357--2366}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{ACS Omega}},
  title        = {{Characterization and Efficacy of a Nanomedical Radiopharmaceutical for Cancer Treatment}},
  url          = {{http://dx.doi.org/10.1021/acsomega.2c06755}},
  doi          = {{10.1021/acsomega.2c06755}},
  volume       = {{8}},
  year         = {{2023}},
}