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Contractile Responses in Spontaneously Hypertensive Rats after Transient Middle Cerebral Artery Occlusion

Grell, Anne Sofie LU ; Mostajeran, Maryam LU ; Edvinsson, Lars LU and Ansar, Saema LU (2018) In Pharmacology 101. p.120-132
Abstract

Stroke is one of the leading causes of mortality and morbidity worldwide, and few therapeutic treatments have shown beneficial effect clinically. One reason for this could be the lack of risk factors incorporated into the preclinical stroke research. We have previously demonstrated phenotypic receptor changes to be one of the injurious mechanisms occurring after stroke but mostly in healthy rats. The aim of this study was to investigate if hypertension has an effect on vasoconstrictive receptor responses to endothelin 1, sarafotoxin 6c and angiotensin II after stroke by inducing transient middle cerebral artery occlusion in spontaneously hypertensive rats and Wistar-Kyoto rats using the wire-myograph. We demonstrated an increased... (More)

Stroke is one of the leading causes of mortality and morbidity worldwide, and few therapeutic treatments have shown beneficial effect clinically. One reason for this could be the lack of risk factors incorporated into the preclinical stroke research. We have previously demonstrated phenotypic receptor changes to be one of the injurious mechanisms occurring after stroke but mostly in healthy rats. The aim of this study was to investigate if hypertension has an effect on vasoconstrictive receptor responses to endothelin 1, sarafotoxin 6c and angiotensin II after stroke by inducing transient middle cerebral artery occlusion in spontaneously hypertensive rats and Wistar-Kyoto rats using the wire-myograph. We demonstrated an increased contractile response to endothelin 1 and extracellular potassium as well as an increased carbachol-induced dilator response in the middle cerebral arteries from hypertensive rats after stroke. This study demonstrates the importance of including risk factors in experimental stroke research.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Endothelin 1, Hypertension, Middle cerebral artery occlusion, Receptor, Spontaneously hypertensive rats, Vasoconstriction, Wire-myograph, Wistar-Kyoto rats
in
Pharmacology
volume
101
pages
120 - 132
publisher
Karger
external identifiers
  • scopus:85035811102
ISSN
0031-7012
DOI
10.1159/000481570
language
English
LU publication?
yes
id
834e88fd-2e7e-4649-8ba6-bf29b65e7b06
date added to LUP
2017-12-12 11:10:49
date last changed
2018-02-19 15:16:39
@article{834e88fd-2e7e-4649-8ba6-bf29b65e7b06,
  abstract     = {<p>Stroke is one of the leading causes of mortality and morbidity worldwide, and few therapeutic treatments have shown beneficial effect clinically. One reason for this could be the lack of risk factors incorporated into the preclinical stroke research. We have previously demonstrated phenotypic receptor changes to be one of the injurious mechanisms occurring after stroke but mostly in healthy rats. The aim of this study was to investigate if hypertension has an effect on vasoconstrictive receptor responses to endothelin 1, sarafotoxin 6c and angiotensin II after stroke by inducing transient middle cerebral artery occlusion in spontaneously hypertensive rats and Wistar-Kyoto rats using the wire-myograph. We demonstrated an increased contractile response to endothelin 1 and extracellular potassium as well as an increased carbachol-induced dilator response in the middle cerebral arteries from hypertensive rats after stroke. This study demonstrates the importance of including risk factors in experimental stroke research.</p>},
  author       = {Grell, Anne Sofie and Mostajeran, Maryam and Edvinsson, Lars and Ansar, Saema},
  issn         = {0031-7012},
  keyword      = {Endothelin 1,Hypertension,Middle cerebral artery occlusion,Receptor,Spontaneously hypertensive rats,Vasoconstriction,Wire-myograph,Wistar-Kyoto rats},
  language     = {eng},
  pages        = {120--132},
  publisher    = {Karger},
  series       = {Pharmacology},
  title        = {Contractile Responses in Spontaneously Hypertensive Rats after Transient Middle Cerebral Artery Occlusion},
  url          = {http://dx.doi.org/10.1159/000481570},
  volume       = {101},
  year         = {2018},
}