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Cryogelation of molecularly imprinted nanoparticles: A macroporous structure as affinity chromatography column for removal of β-blockers from complex samples.

Hajizadeh, Solmaz LU ; Xu, Changgang LU ; Kirsebom, Harald LU ; Ye, Lei LU and Mattiasson, Bo LU (2013) In Journal of chromatography. A 1274. p.6-12
Abstract
In this work, a new macroporous molecularly imprinted cryogel (MIP composite cryogel) was synthesized by glutaraldehyde cross-linking reaction of poly(vinyl alcohol) (PVA) particles and amino-modified molecularly imprinted core-shell nanoparticles. The MIP core-shell nanoparticles were prepared using propranolol as a template by one-pot precipitation polymerization with sequential monomer addition. The characteristics of the MIP composite cryogel were studied by scanning electron microscopy (SEM) and texture analyzer. The macroporous structure of the composite (with the pore size varying from a few micrometers to 100μm) enabled high mass transfer of particulate-containing fluids. In a solid phase extraction (SPE) process, the efficiency... (More)
In this work, a new macroporous molecularly imprinted cryogel (MIP composite cryogel) was synthesized by glutaraldehyde cross-linking reaction of poly(vinyl alcohol) (PVA) particles and amino-modified molecularly imprinted core-shell nanoparticles. The MIP core-shell nanoparticles were prepared using propranolol as a template by one-pot precipitation polymerization with sequential monomer addition. The characteristics of the MIP composite cryogel were studied by scanning electron microscopy (SEM) and texture analyzer. The macroporous structure of the composite (with the pore size varying from a few micrometers to 100μm) enabled high mass transfer of particulate-containing fluids. In a solid phase extraction (SPE) process, the efficiency and selectivity of the MIP composite cryogel were investigated, where the cryogel was used as an affinity matrix to remove propranolol from aqueous solution as well as from complex plasma sample without prior protein precipitation. The MIP composite cryogel maintained high selectivity and stability and could be used repeatedly after regeneration. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Composite cryogel, Molecularly imprinted polymer, Affinity, chromatography, Complex media
in
Journal of chromatography. A
volume
1274
pages
6 - 12
publisher
Elsevier
external identifiers
  • wos:000314443300002
  • pmid:23290362
  • scopus:84872338024
ISSN
1873-3778
DOI
10.1016/j.chroma.2012.10.073
language
English
LU publication?
yes
id
835504db-a4e5-459f-baa4-41ff7576d35b (old id 3439001)
date added to LUP
2013-02-06 09:42:36
date last changed
2019-03-17 03:59:51
@article{835504db-a4e5-459f-baa4-41ff7576d35b,
  abstract     = {In this work, a new macroporous molecularly imprinted cryogel (MIP composite cryogel) was synthesized by glutaraldehyde cross-linking reaction of poly(vinyl alcohol) (PVA) particles and amino-modified molecularly imprinted core-shell nanoparticles. The MIP core-shell nanoparticles were prepared using propranolol as a template by one-pot precipitation polymerization with sequential monomer addition. The characteristics of the MIP composite cryogel were studied by scanning electron microscopy (SEM) and texture analyzer. The macroporous structure of the composite (with the pore size varying from a few micrometers to 100μm) enabled high mass transfer of particulate-containing fluids. In a solid phase extraction (SPE) process, the efficiency and selectivity of the MIP composite cryogel were investigated, where the cryogel was used as an affinity matrix to remove propranolol from aqueous solution as well as from complex plasma sample without prior protein precipitation. The MIP composite cryogel maintained high selectivity and stability and could be used repeatedly after regeneration.},
  author       = {Hajizadeh, Solmaz and Xu, Changgang and Kirsebom, Harald and Ye, Lei and Mattiasson, Bo},
  issn         = {1873-3778},
  keyword      = {Composite cryogel,Molecularly imprinted polymer,Affinity,chromatography,Complex media},
  language     = {eng},
  pages        = {6--12},
  publisher    = {Elsevier},
  series       = {Journal of chromatography. A},
  title        = {Cryogelation of molecularly imprinted nanoparticles: A macroporous structure as affinity chromatography column for removal of β-blockers from complex samples.},
  url          = {http://dx.doi.org/10.1016/j.chroma.2012.10.073},
  volume       = {1274},
  year         = {2013},
}