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Pre- and postcontrast T1 and T2 mapping of patellar cartilage in young adults with recurrent patellar dislocation

Mostroem, Eva Bengtsson; Lammentausta, Eveliina; Finnbogason, Throestur; Weidenhielm, Lars; Janarv, Per-Mats and Tiderius, Carl Johan LU (2015) In Magnetic Resonance in Medicine 74(5). p.1363-1369
Abstract
PurposeTo examine the cartilage quality in young adults with recurrent patellar dislocation in childhood using different magnetic resonance imaging parameters. MethodsSixteen young adults with unilateral recurrent patellar dislocation were investigated 5 y (mean, 8.5 y) after the first dislocation. Pre- and postcontrast T1 and precontrast T2 relaxation times were analyzed in four superficial and four deep patellar cartilage regions of both knees. Two hours after intravenous injection of 0.2 mM/kg Gd-DTPA(2-), postcontrast T1 [T1(Gd)] and R1 [1/T1 (precontrast)-1/T1 (postcontrast)] were analyzed in the regions. Muscle performance and patient-reported outcome were evaluated. ResultsWhen comparing the injured side with the noninjured side,... (More)
PurposeTo examine the cartilage quality in young adults with recurrent patellar dislocation in childhood using different magnetic resonance imaging parameters. MethodsSixteen young adults with unilateral recurrent patellar dislocation were investigated 5 y (mean, 8.5 y) after the first dislocation. Pre- and postcontrast T1 and precontrast T2 relaxation times were analyzed in four superficial and four deep patellar cartilage regions of both knees. Two hours after intravenous injection of 0.2 mM/kg Gd-DTPA(2-), postcontrast T1 [T1(Gd)] and R1 [1/T1 (precontrast)-1/T1 (postcontrast)] were analyzed in the regions. Muscle performance and patient-reported outcome were evaluated. ResultsWhen comparing the injured side with the noninjured side, differences were seen in the superficial half but not the deep half of the cartilage. T1(Gd) was shorter in the central part, whereas T2 was shorter in the periphery of the patellar cartilage (P<0.05). R1 demonstrated similar differences between healthy and diseased cartilage as T1(Gd) alone. The knee function was not correlated to the degenerative changes. ConclusionThe short T1(Gd) centrally indicates degenerative cartilage changes consistent with loss of glycosaminoglycans. Precontrast and R1 calculations may be excluded in clinical dGEMRIC, which simplifies the procedure. A decrease in T2 may be a very early sign of joint pathology but warrants further investigation. Magn Reson Med 74:1363-1369, 2015. (c) 2014 Wiley Periodicals, Inc. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
osteoarthritis, patellar dislocation, T2, dGEMRIC
in
Magnetic Resonance in Medicine
volume
74
issue
5
pages
1363 - 1369
publisher
Wiley Online Library
external identifiers
  • wos:000364215900017
  • scopus:84944719744
ISSN
1522-2594
DOI
10.1002/mrm.25511
language
English
LU publication?
yes
id
f8905dda-3662-4a93-afd3-7c5d46e962c9 (old id 8380495)
date added to LUP
2016-01-04 07:04:49
date last changed
2017-07-30 03:23:21
@article{f8905dda-3662-4a93-afd3-7c5d46e962c9,
  abstract     = {PurposeTo examine the cartilage quality in young adults with recurrent patellar dislocation in childhood using different magnetic resonance imaging parameters. MethodsSixteen young adults with unilateral recurrent patellar dislocation were investigated 5 y (mean, 8.5 y) after the first dislocation. Pre- and postcontrast T1 and precontrast T2 relaxation times were analyzed in four superficial and four deep patellar cartilage regions of both knees. Two hours after intravenous injection of 0.2 mM/kg Gd-DTPA(2-), postcontrast T1 [T1(Gd)] and R1 [1/T1 (precontrast)-1/T1 (postcontrast)] were analyzed in the regions. Muscle performance and patient-reported outcome were evaluated. ResultsWhen comparing the injured side with the noninjured side, differences were seen in the superficial half but not the deep half of the cartilage. T1(Gd) was shorter in the central part, whereas T2 was shorter in the periphery of the patellar cartilage (P&lt;0.05). R1 demonstrated similar differences between healthy and diseased cartilage as T1(Gd) alone. The knee function was not correlated to the degenerative changes. ConclusionThe short T1(Gd) centrally indicates degenerative cartilage changes consistent with loss of glycosaminoglycans. Precontrast and R1 calculations may be excluded in clinical dGEMRIC, which simplifies the procedure. A decrease in T2 may be a very early sign of joint pathology but warrants further investigation. Magn Reson Med 74:1363-1369, 2015. (c) 2014 Wiley Periodicals, Inc.},
  author       = {Mostroem, Eva Bengtsson and Lammentausta, Eveliina and Finnbogason, Throestur and Weidenhielm, Lars and Janarv, Per-Mats and Tiderius, Carl Johan},
  issn         = {1522-2594},
  keyword      = {osteoarthritis,patellar dislocation,T2,dGEMRIC},
  language     = {eng},
  number       = {5},
  pages        = {1363--1369},
  publisher    = {Wiley Online Library},
  series       = {Magnetic Resonance in Medicine},
  title        = {Pre- and postcontrast T1 and T2 mapping of patellar cartilage in young adults with recurrent patellar dislocation},
  url          = {http://dx.doi.org/10.1002/mrm.25511},
  volume       = {74},
  year         = {2015},
}