Antimuscarinics for treatment of overactive bladder
Andersson, Karl-Erik LU
(2004)
In Lancet Neurology
3(1).
p.46-53
- Abstract
- For many years, antimuscarinic drugs have been the first-line pharmacological treatment for urgency, frequency, and urge incontinence, all symptoms of the disorder termed overactive bladder. Antimuscarinic treatment is not always effective and is associated with side-effects that limit its clinical use. The clinical significance of the effects of antimuscarinic drugs has been questioned lately. In this review, the rationale for the use of these drugs in the management of overactive bladder is re-examined and the results of treatment are discussed. I conclude that these drugs are the only treatment with undisputed effectiveness in the treatment of overactive bladder. They may not be the perfect treatment for all patients with this disorder,... (More)
- For many years, antimuscarinic drugs have been the first-line pharmacological treatment for urgency, frequency, and urge incontinence, all symptoms of the disorder termed overactive bladder. Antimuscarinic treatment is not always effective and is associated with side-effects that limit its clinical use. The clinical significance of the effects of antimuscarinic drugs has been questioned lately. In this review, the rationale for the use of these drugs in the management of overactive bladder is re-examined and the results of treatment are discussed. I conclude that these drugs are the only treatment with undisputed effectiveness in the treatment of overactive bladder. They may not be the perfect treatment for all patients with this disorder, but their value for individual patients should not be underestimated. Further clinical trials with improvement in quality of life as the primary endpoint are needed and may give a fair reflection of the clinical value of antimuscarinic drugs. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/291320
- author
- Andersson, Karl-Erik
LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Lancet Neurology
- volume
- 3
- issue
- 1
- pages
- 46 - 53
- publisher
- Lancet Publishing Group
- external identifiers
-
- pmid:14693111
- wos:000187447100025
- scopus:0346250806
- ISSN
- 1474-4465
- DOI
- 10.1016/S1474-4422(03)00622-7
- language
- English
- LU publication?
- yes
- id
- 83f1ac6c-a9fb-4985-b1f9-df5277025340 (old id 291320)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14693111&dopt=Abstract
- date added to LUP
- 2016-04-01 12:28:35
- date last changed
- 2022-03-13 18:27:36
@article{83f1ac6c-a9fb-4985-b1f9-df5277025340,
abstract = {{For many years, antimuscarinic drugs have been the first-line pharmacological treatment for urgency, frequency, and urge incontinence, all symptoms of the disorder termed overactive bladder. Antimuscarinic treatment is not always effective and is associated with side-effects that limit its clinical use. The clinical significance of the effects of antimuscarinic drugs has been questioned lately. In this review, the rationale for the use of these drugs in the management of overactive bladder is re-examined and the results of treatment are discussed. I conclude that these drugs are the only treatment with undisputed effectiveness in the treatment of overactive bladder. They may not be the perfect treatment for all patients with this disorder, but their value for individual patients should not be underestimated. Further clinical trials with improvement in quality of life as the primary endpoint are needed and may give a fair reflection of the clinical value of antimuscarinic drugs.}},
author = {{Andersson, Karl-Erik}},
issn = {{1474-4465}},
language = {{eng}},
number = {{1}},
pages = {{46--53}},
publisher = {{Lancet Publishing Group}},
series = {{Lancet Neurology}},
title = {{Antimuscarinics for treatment of overactive bladder}},
url = {{http://dx.doi.org/10.1016/S1474-4422(03)00622-7}},
doi = {{10.1016/S1474-4422(03)00622-7}},
volume = {{3}},
year = {{2004}},
}