Solid-phase extraction for combinatorial libraries
(2000) In Journal of Chromatography A 885(1-2). p.305-319- Abstract
Solid-phase extraction (SPE) has during the last three years emerged as a convenient method for the purification of compound libraries prepared by solution synthesis. The widespread use of SPE in combinatorial chemistry can be explained by straightforward SPE method development facilitated by the availability of numerous commercial SPE resins. High-speed automated SPE is readily accomplished by taking advantage of commercial laboratory robot systems. The present review summarizes and discusses advancements made in the use of different SPE resins and molecule tagging techniques for optimization of ion-exchange, reversed-phase, normal-phase and fluorous-phase SPE in combinatorial chemistry.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/83ff967e-7114-47fe-ab08-36012515ebe9
- author
- Nilsson, Ulf J. LU
- organization
- publishing date
- 2000-07-14
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Combinatorial chemistry, Review, Solid-phase extraction, Synthesis
- in
- Journal of Chromatography A
- volume
- 885
- issue
- 1-2
- pages
- 15 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:10941679
- scopus:0034648070
- ISSN
- 0021-9673
- DOI
- 10.1016/S0021-9673(99)01095-X
- language
- English
- LU publication?
- yes
- id
- 83ff967e-7114-47fe-ab08-36012515ebe9
- date added to LUP
- 2023-02-07 08:55:30
- date last changed
- 2024-04-18 18:36:08
@article{83ff967e-7114-47fe-ab08-36012515ebe9,
abstract = {{<p>Solid-phase extraction (SPE) has during the last three years emerged as a convenient method for the purification of compound libraries prepared by solution synthesis. The widespread use of SPE in combinatorial chemistry can be explained by straightforward SPE method development facilitated by the availability of numerous commercial SPE resins. High-speed automated SPE is readily accomplished by taking advantage of commercial laboratory robot systems. The present review summarizes and discusses advancements made in the use of different SPE resins and molecule tagging techniques for optimization of ion-exchange, reversed-phase, normal-phase and fluorous-phase SPE in combinatorial chemistry.<br/></p>}},
author = {{Nilsson, Ulf J.}},
issn = {{0021-9673}},
keywords = {{Combinatorial chemistry; Review; Solid-phase extraction; Synthesis}},
language = {{eng}},
month = {{07}},
number = {{1-2}},
pages = {{305--319}},
publisher = {{Elsevier}},
series = {{Journal of Chromatography A}},
title = {{Solid-phase extraction for combinatorial libraries}},
url = {{http://dx.doi.org/10.1016/S0021-9673(99)01095-X}},
doi = {{10.1016/S0021-9673(99)01095-X}},
volume = {{885}},
year = {{2000}},
}