Acute posterior reversible encephalopathy syndrome (PRES) in setting of interferon-beta use : case presentation with reduction of edema in 72 h after cessation of interferon-beta therapy with sub-clinical inflammation
(2021) In BMC Neurology 21(1).- Abstract
Background: Posterior reversible encephalopathy syndrome (PRES) represents a transient change in mental status with associated vasogenic edema of cortical and subcortical brain structures. It is often attributed to multifactorial etiology including hypertension and altered hemodynamics and disruption of vessel integrity. Patients with autoimmune disease and certain immune modulator therapies are at greater risk. Case presentation: A 54-year-old female with past medical history of well-controlled multiple sclerosis on interferon-beta since 2013, presented with witnessed tonic colonic seizure. She also was noted to demonstrate left gaze deviation and left-sided hemiparesis. MRI fluid-attenuated inversion recovery sequence showed... (More)
Background: Posterior reversible encephalopathy syndrome (PRES) represents a transient change in mental status with associated vasogenic edema of cortical and subcortical brain structures. It is often attributed to multifactorial etiology including hypertension and altered hemodynamics and disruption of vessel integrity. Patients with autoimmune disease and certain immune modulator therapies are at greater risk. Case presentation: A 54-year-old female with past medical history of well-controlled multiple sclerosis on interferon-beta since 2013, presented with witnessed tonic colonic seizure. She also was noted to demonstrate left gaze deviation and left-sided hemiparesis. MRI fluid-attenuated inversion recovery sequence showed hyperintensity of the subcortical U fibers, concentrated in the occipital, parietal lobes and frontal lobes. Systolic blood pressure was 160 mmHg on arrival. The patient was started on seizure prophylxis and Interferon beta was discontinued. The patient’s mentation, seizures and hemiapresis significantly improved in next 72 h with tight blood pressure control, and had notble improvement on MRI imaging and inflammatory markers. Lumbar puncture CSF results were devoid of infectious and autoimmune pathology. Conclusions: A middle-aged female with multiple sclerosis who was on chronic IFN-beta presented to the emergency room with a witnessed tonic-clonic seizure, with MRI T2 FLAIR imaging consistent with PRES. She had notable clinical improvement with decreased edema on imaging and improved inflammatory markers 72 h after cessation of IFN-beta therapy.
(Less)
- author
- Dietz, Nicholas ; Mufti, Zarmina ; Yousaf, Muhammed ; Brown, Randal ; Counts, Christopher ; Bjurström, Martin F. LU ; Williams, Brian J. and Robertson, David
- publishing date
- 2021-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Case report, Hypertension, Interferon, Multiple sclerosis, Posterior reversible encephalopathy syndrome, Seizure
- in
- BMC Neurology
- volume
- 21
- issue
- 1
- article number
- 445
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:85118807783
- pmid:34758765
- ISSN
- 1471-2377
- DOI
- 10.1186/s12883-021-02471-7
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © 2021, The Author(s).
- id
- 8408c12c-1542-42d3-8417-9105c408766f
- date added to LUP
- 2022-01-21 16:24:01
- date last changed
- 2024-06-16 00:16:29
@article{8408c12c-1542-42d3-8417-9105c408766f,
abstract = {{<p>Background: Posterior reversible encephalopathy syndrome (PRES) represents a transient change in mental status with associated vasogenic edema of cortical and subcortical brain structures. It is often attributed to multifactorial etiology including hypertension and altered hemodynamics and disruption of vessel integrity. Patients with autoimmune disease and certain immune modulator therapies are at greater risk. Case presentation: A 54-year-old female with past medical history of well-controlled multiple sclerosis on interferon-beta since 2013, presented with witnessed tonic colonic seizure. She also was noted to demonstrate left gaze deviation and left-sided hemiparesis. MRI fluid-attenuated inversion recovery sequence showed hyperintensity of the subcortical U fibers, concentrated in the occipital, parietal lobes and frontal lobes. Systolic blood pressure was 160 mmHg on arrival. The patient was started on seizure prophylxis and Interferon beta was discontinued. The patient’s mentation, seizures and hemiapresis significantly improved in next 72 h with tight blood pressure control, and had notble improvement on MRI imaging and inflammatory markers. Lumbar puncture CSF results were devoid of infectious and autoimmune pathology. Conclusions: A middle-aged female with multiple sclerosis who was on chronic IFN-beta presented to the emergency room with a witnessed tonic-clonic seizure, with MRI T2 FLAIR imaging consistent with PRES. She had notable clinical improvement with decreased edema on imaging and improved inflammatory markers 72 h after cessation of IFN-beta therapy.</p>}},
author = {{Dietz, Nicholas and Mufti, Zarmina and Yousaf, Muhammed and Brown, Randal and Counts, Christopher and Bjurström, Martin F. and Williams, Brian J. and Robertson, David}},
issn = {{1471-2377}},
keywords = {{Case report; Hypertension; Interferon; Multiple sclerosis; Posterior reversible encephalopathy syndrome; Seizure}},
language = {{eng}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Neurology}},
title = {{Acute posterior reversible encephalopathy syndrome (PRES) in setting of interferon-beta use : case presentation with reduction of edema in 72 h after cessation of interferon-beta therapy with sub-clinical inflammation}},
url = {{http://dx.doi.org/10.1186/s12883-021-02471-7}},
doi = {{10.1186/s12883-021-02471-7}},
volume = {{21}},
year = {{2021}},
}