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Simvastatin and zinc synergistically enhance osteoblasts activity and decrease the acute response of inflammatory cells.

Montazerolghaem, Maryam; Ning, Yi; Engqvist, Håkan; Karlsson Ott, Marjam; Tenje, Maria LU and Mestres, Gemma (2016) In Journal of Materials Science: Materials in Medicine 27(2). p.23-23
Abstract
Several ceramic biomaterials have been suggested as promising alternatives to autologous bone to replace or restore bone after trauma or disease. The osteoinductive potential of most scaffolds is often rather low by themselves and for this reason growth factors or drugs have been supplemented to these synthetic materials. Although some growth factors show good osteoinductive potential their drawback is their high cost and potential severe side effects. In this work the combination of the well-known drug simvastatin (SVA) and the inorganic element Zinc (Zn) is suggested as a potential additive to bone grafts in order to increase their bone regeneration/formation. MC3T3-E1 cells were cultured with Zn (10 and 25 µM) and SVA (0.25 and 0.4 µM)... (More)
Several ceramic biomaterials have been suggested as promising alternatives to autologous bone to replace or restore bone after trauma or disease. The osteoinductive potential of most scaffolds is often rather low by themselves and for this reason growth factors or drugs have been supplemented to these synthetic materials. Although some growth factors show good osteoinductive potential their drawback is their high cost and potential severe side effects. In this work the combination of the well-known drug simvastatin (SVA) and the inorganic element Zinc (Zn) is suggested as a potential additive to bone grafts in order to increase their bone regeneration/formation. MC3T3-E1 cells were cultured with Zn (10 and 25 µM) and SVA (0.25 and 0.4 µM) for 10 days to evaluate proliferation and differentiation, and for 22 days to evaluate secretion of calcium deposits. The combination of Zn (10 µM) and SVA (0.25 µM) significantly enhanced cell differentiation and mineralization in a synergetic manner. In addition, the release of reactive oxygen species (ROS) from primary human monocytes in contact with the same concentrations of Zn and SVA was evaluated by chemiluminescence. The combination of the additives decreased the release of ROS, although Zn and SVA separately caused opposite effects. This work shows that a new combination of additives can be used to increase the osteoinductive capacity of porous bioceramics. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Materials Science: Materials in Medicine
volume
27
issue
2
pages
23 - 23
publisher
Kluwer
external identifiers
  • pmid:26704540
  • wos:000368726300002
  • scopus:84951292637
ISSN
1573-4838
DOI
10.1007/s10856-015-5639-4
language
English
LU publication?
yes
id
60b2a434-1275-41f7-8853-89d352c20d5c (old id 8503545)
date added to LUP
2016-01-19 10:49:14
date last changed
2017-11-12 03:09:20
@article{60b2a434-1275-41f7-8853-89d352c20d5c,
  abstract     = {Several ceramic biomaterials have been suggested as promising alternatives to autologous bone to replace or restore bone after trauma or disease. The osteoinductive potential of most scaffolds is often rather low by themselves and for this reason growth factors or drugs have been supplemented to these synthetic materials. Although some growth factors show good osteoinductive potential their drawback is their high cost and potential severe side effects. In this work the combination of the well-known drug simvastatin (SVA) and the inorganic element Zinc (Zn) is suggested as a potential additive to bone grafts in order to increase their bone regeneration/formation. MC3T3-E1 cells were cultured with Zn (10 and 25 µM) and SVA (0.25 and 0.4 µM) for 10 days to evaluate proliferation and differentiation, and for 22 days to evaluate secretion of calcium deposits. The combination of Zn (10 µM) and SVA (0.25 µM) significantly enhanced cell differentiation and mineralization in a synergetic manner. In addition, the release of reactive oxygen species (ROS) from primary human monocytes in contact with the same concentrations of Zn and SVA was evaluated by chemiluminescence. The combination of the additives decreased the release of ROS, although Zn and SVA separately caused opposite effects. This work shows that a new combination of additives can be used to increase the osteoinductive capacity of porous bioceramics.},
  author       = {Montazerolghaem, Maryam and Ning, Yi and Engqvist, Håkan and Karlsson Ott, Marjam and Tenje, Maria and Mestres, Gemma},
  issn         = {1573-4838},
  language     = {eng},
  number       = {2},
  pages        = {23--23},
  publisher    = {Kluwer},
  series       = {Journal of Materials Science: Materials in Medicine},
  title        = {Simvastatin and zinc synergistically enhance osteoblasts activity and decrease the acute response of inflammatory cells.},
  url          = {http://dx.doi.org/10.1007/s10856-015-5639-4},
  volume       = {27},
  year         = {2016},
}