Whole-Body and Microenvironmental Localization of Radium-223 in Naïve and Mouse Models of Prostate Cancer Metastasis.
(2016) In Journal of the National Cancer Institute 108(5).- Abstract
- Bone-metastatic, castration-resistant prostate cancer (bmCRPC) represents a lethal stage of the most common noncutaneous cancer in men. The recent introduction of Radium-223 dichloride, a bone-seeking alpha particle (α)-emitting radiopharmaceutical, demonstrates statistically significant survival benefit and palliative effect for bmCRPC patients. Clinical results have established safety and efficacy, yet questions remain regarding pharmacodynamics and dosing for optimized patient benefit.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8504218
- author
- Abou, Diane S ; Ulmert, David LU ; Doucet, Michele ; Hobbs, Robert F ; Riddle, Ryan C and Thorek, Daniel L J
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of the National Cancer Institute
- volume
- 108
- issue
- 5
- article number
- djv380
- publisher
- Oxford University Press
- external identifiers
-
- pmid:26683407
- scopus:84968835168
- pmid:26683407
- wos:000375404600001
- ISSN
- 1460-2105
- DOI
- 10.1093/jnci/djv380
- language
- English
- LU publication?
- yes
- id
- cfe84a7d-4143-4be5-b701-92e55d995ef2 (old id 8504218)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26683407?dopt=Abstract
- date added to LUP
- 2016-04-04 09:28:44
- date last changed
- 2022-05-09 05:08:14
@article{cfe84a7d-4143-4be5-b701-92e55d995ef2,
abstract = {{Bone-metastatic, castration-resistant prostate cancer (bmCRPC) represents a lethal stage of the most common noncutaneous cancer in men. The recent introduction of Radium-223 dichloride, a bone-seeking alpha particle (α)-emitting radiopharmaceutical, demonstrates statistically significant survival benefit and palliative effect for bmCRPC patients. Clinical results have established safety and efficacy, yet questions remain regarding pharmacodynamics and dosing for optimized patient benefit.}},
author = {{Abou, Diane S and Ulmert, David and Doucet, Michele and Hobbs, Robert F and Riddle, Ryan C and Thorek, Daniel L J}},
issn = {{1460-2105}},
language = {{eng}},
number = {{5}},
publisher = {{Oxford University Press}},
series = {{Journal of the National Cancer Institute}},
title = {{Whole-Body and Microenvironmental Localization of Radium-223 in Naïve and Mouse Models of Prostate Cancer Metastasis.}},
url = {{http://dx.doi.org/10.1093/jnci/djv380}},
doi = {{10.1093/jnci/djv380}},
volume = {{108}},
year = {{2016}},
}