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Whole-Body and Microenvironmental Localization of Radium-223 in Naïve and Mouse Models of Prostate Cancer Metastasis.

Abou, Diane S; Ulmert, David LU ; Doucet, Michele; Hobbs, Robert F; Riddle, Ryan C and Thorek, Daniel L J (2016) In Journal of the National Cancer Institute 108(5).
Abstract
Bone-metastatic, castration-resistant prostate cancer (bmCRPC) represents a lethal stage of the most common noncutaneous cancer in men. The recent introduction of Radium-223 dichloride, a bone-seeking alpha particle (α)-emitting radiopharmaceutical, demonstrates statistically significant survival benefit and palliative effect for bmCRPC patients. Clinical results have established safety and efficacy, yet questions remain regarding pharmacodynamics and dosing for optimized patient benefit.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of the National Cancer Institute
volume
108
issue
5
publisher
Oxford University Press
external identifiers
  • pmid:26683407
  • scopus:84968835168
  • wos:000375404600001
ISSN
1460-2105
DOI
10.1093/jnci/djv380
language
English
LU publication?
yes
id
cfe84a7d-4143-4be5-b701-92e55d995ef2 (old id 8504218)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26683407?dopt=Abstract
date added to LUP
2016-01-12 12:35:08
date last changed
2017-01-01 07:49:38
@article{cfe84a7d-4143-4be5-b701-92e55d995ef2,
  abstract     = {Bone-metastatic, castration-resistant prostate cancer (bmCRPC) represents a lethal stage of the most common noncutaneous cancer in men. The recent introduction of Radium-223 dichloride, a bone-seeking alpha particle (α)-emitting radiopharmaceutical, demonstrates statistically significant survival benefit and palliative effect for bmCRPC patients. Clinical results have established safety and efficacy, yet questions remain regarding pharmacodynamics and dosing for optimized patient benefit.},
  articleno    = {djv380},
  author       = {Abou, Diane S and Ulmert, David and Doucet, Michele and Hobbs, Robert F and Riddle, Ryan C and Thorek, Daniel L J},
  issn         = {1460-2105},
  language     = {eng},
  number       = {5},
  publisher    = {Oxford University Press},
  series       = {Journal of the National Cancer Institute},
  title        = {Whole-Body and Microenvironmental Localization of Radium-223 in Naïve and Mouse Models of Prostate Cancer Metastasis.},
  url          = {http://dx.doi.org/10.1093/jnci/djv380},
  volume       = {108},
  year         = {2016},
}