Radiation treatment monitoring using multimodal functional imaging: PET/CT ((18)F-Fluoromisonidazole & (18)F-Fluorocholine) and DCE-US.
(2015) In Journal of Translational Medicine 13.- Abstract
- This study aims to assess the effect of radiation treatment on the tumour vasculature and its downstream effects on hypoxia and choline metabolism using a multimodal approach in the murine prostate tumour model CWR22. Functional parameters derived from Positron Emission Tomography (PET)/Computer Tomography (CT) with (18)F-Fluoromisonidazole ((18)F-FMISO) and (18)F-Fluorocholine ((18)F-FCH) as well as Dynamic Contrast-Enhanced Ultrasound (DCE-US) were employed to determine the relationship between metabolic parameters and microvascular parameters that reflect the tumour microenvironment. Immunohistochemical analysis was employed for validation.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8504302
- author
- Arteaga-Marrero, Natalia ; Brekke Rygh, Cecilie ; Mainou-Gomez, Jose F ; Adamsen, Tom C H ; Lutay, Nataliya LU ; Reed, Rolf K and Olsen, Dag R
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Translational Medicine
- volume
- 13
- article number
- 383
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:26682742
- wos:000367152700001
- scopus:84949949881
- pmid:26682742
- ISSN
- 1479-5876
- DOI
- 10.1186/s12967-015-0708-5
- language
- English
- LU publication?
- yes
- id
- 89491565-5eb0-44f6-9167-c3078aa6ed4f (old id 8504302)
- date added to LUP
- 2016-04-01 15:01:57
- date last changed
- 2022-01-28 03:43:10
@article{89491565-5eb0-44f6-9167-c3078aa6ed4f, abstract = {{This study aims to assess the effect of radiation treatment on the tumour vasculature and its downstream effects on hypoxia and choline metabolism using a multimodal approach in the murine prostate tumour model CWR22. Functional parameters derived from Positron Emission Tomography (PET)/Computer Tomography (CT) with (18)F-Fluoromisonidazole ((18)F-FMISO) and (18)F-Fluorocholine ((18)F-FCH) as well as Dynamic Contrast-Enhanced Ultrasound (DCE-US) were employed to determine the relationship between metabolic parameters and microvascular parameters that reflect the tumour microenvironment. Immunohistochemical analysis was employed for validation.}}, author = {{Arteaga-Marrero, Natalia and Brekke Rygh, Cecilie and Mainou-Gomez, Jose F and Adamsen, Tom C H and Lutay, Nataliya and Reed, Rolf K and Olsen, Dag R}}, issn = {{1479-5876}}, language = {{eng}}, publisher = {{BioMed Central (BMC)}}, series = {{Journal of Translational Medicine}}, title = {{Radiation treatment monitoring using multimodal functional imaging: PET/CT ((18)F-Fluoromisonidazole & (18)F-Fluorocholine) and DCE-US.}}, url = {{http://dx.doi.org/10.1186/s12967-015-0708-5}}, doi = {{10.1186/s12967-015-0708-5}}, volume = {{13}}, year = {{2015}}, }