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Radiation treatment monitoring using multimodal functional imaging: PET/CT ((18)F-Fluoromisonidazole & (18)F-Fluorocholine) and DCE-US.

Arteaga-Marrero, Natalia ; Brekke Rygh, Cecilie ; Mainou-Gomez, Jose F ; Adamsen, Tom C H ; Lutay, Nataliya LU ; Reed, Rolf K and Olsen, Dag R (2015) In Journal of Translational Medicine 13.
Abstract
This study aims to assess the effect of radiation treatment on the tumour vasculature and its downstream effects on hypoxia and choline metabolism using a multimodal approach in the murine prostate tumour model CWR22. Functional parameters derived from Positron Emission Tomography (PET)/Computer Tomography (CT) with (18)F-Fluoromisonidazole ((18)F-FMISO) and (18)F-Fluorocholine ((18)F-FCH) as well as Dynamic Contrast-Enhanced Ultrasound (DCE-US) were employed to determine the relationship between metabolic parameters and microvascular parameters that reflect the tumour microenvironment. Immunohistochemical analysis was employed for validation.
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Translational Medicine
volume
13
article number
383
publisher
BioMed Central (BMC)
external identifiers
  • pmid:26682742
  • wos:000367152700001
  • scopus:84949949881
  • pmid:26682742
ISSN
1479-5876
DOI
10.1186/s12967-015-0708-5
language
English
LU publication?
yes
id
89491565-5eb0-44f6-9167-c3078aa6ed4f (old id 8504302)
date added to LUP
2016-04-01 15:01:57
date last changed
2022-01-28 03:43:10
@article{89491565-5eb0-44f6-9167-c3078aa6ed4f,
  abstract     = {{This study aims to assess the effect of radiation treatment on the tumour vasculature and its downstream effects on hypoxia and choline metabolism using a multimodal approach in the murine prostate tumour model CWR22. Functional parameters derived from Positron Emission Tomography (PET)/Computer Tomography (CT) with (18)F-Fluoromisonidazole ((18)F-FMISO) and (18)F-Fluorocholine ((18)F-FCH) as well as Dynamic Contrast-Enhanced Ultrasound (DCE-US) were employed to determine the relationship between metabolic parameters and microvascular parameters that reflect the tumour microenvironment. Immunohistochemical analysis was employed for validation.}},
  author       = {{Arteaga-Marrero, Natalia and Brekke Rygh, Cecilie and Mainou-Gomez, Jose F and Adamsen, Tom C H and Lutay, Nataliya and Reed, Rolf K and Olsen, Dag R}},
  issn         = {{1479-5876}},
  language     = {{eng}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Journal of Translational Medicine}},
  title        = {{Radiation treatment monitoring using multimodal functional imaging: PET/CT ((18)F-Fluoromisonidazole & (18)F-Fluorocholine) and DCE-US.}},
  url          = {{http://dx.doi.org/10.1186/s12967-015-0708-5}},
  doi          = {{10.1186/s12967-015-0708-5}},
  volume       = {{13}},
  year         = {{2015}},
}