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Radiation treatment monitoring using multimodal functional imaging: PET/CT ((18)F-Fluoromisonidazole & (18)F-Fluorocholine) and DCE-US.

Arteaga-Marrero, Natalia; Brekke Rygh, Cecilie; Mainou-Gomez, Jose F; Adamsen, Tom C H; Lutay, Nataliya LU ; Reed, Rolf K and Olsen, Dag R (2015) In Journal of Translational Medicine 13.
Abstract
This study aims to assess the effect of radiation treatment on the tumour vasculature and its downstream effects on hypoxia and choline metabolism using a multimodal approach in the murine prostate tumour model CWR22. Functional parameters derived from Positron Emission Tomography (PET)/Computer Tomography (CT) with (18)F-Fluoromisonidazole ((18)F-FMISO) and (18)F-Fluorocholine ((18)F-FCH) as well as Dynamic Contrast-Enhanced Ultrasound (DCE-US) were employed to determine the relationship between metabolic parameters and microvascular parameters that reflect the tumour microenvironment. Immunohistochemical analysis was employed for validation.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Translational Medicine
volume
13
publisher
BioMed Central
external identifiers
  • pmid:26682742
  • wos:000367152700001
  • scopus:84949949881
ISSN
1479-5876
DOI
10.1186/s12967-015-0708-5
language
English
LU publication?
yes
id
89491565-5eb0-44f6-9167-c3078aa6ed4f (old id 8504302)
date added to LUP
2016-01-05 22:19:28
date last changed
2017-02-01 15:48:46
@article{89491565-5eb0-44f6-9167-c3078aa6ed4f,
  abstract     = {This study aims to assess the effect of radiation treatment on the tumour vasculature and its downstream effects on hypoxia and choline metabolism using a multimodal approach in the murine prostate tumour model CWR22. Functional parameters derived from Positron Emission Tomography (PET)/Computer Tomography (CT) with (18)F-Fluoromisonidazole ((18)F-FMISO) and (18)F-Fluorocholine ((18)F-FCH) as well as Dynamic Contrast-Enhanced Ultrasound (DCE-US) were employed to determine the relationship between metabolic parameters and microvascular parameters that reflect the tumour microenvironment. Immunohistochemical analysis was employed for validation.},
  articleno    = {383},
  author       = {Arteaga-Marrero, Natalia and Brekke Rygh, Cecilie and Mainou-Gomez, Jose F and Adamsen, Tom C H and Lutay, Nataliya and Reed, Rolf K and Olsen, Dag R},
  issn         = {1479-5876},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {Journal of Translational Medicine},
  title        = {Radiation treatment monitoring using multimodal functional imaging: PET/CT ((18)F-Fluoromisonidazole & (18)F-Fluorocholine) and DCE-US.},
  url          = {http://dx.doi.org/10.1186/s12967-015-0708-5},
  volume       = {13},
  year         = {2015},
}