Tasquinimod triggers an early change in the polarization of tumor associated macrophages in the tumor microenvironment.
(2015) In Journal for ImmunoTherapy of Cancer 3.- Abstract
- Tasquinimod (a quinoline-3-carboxyamide) is a small molecule immunotherapy with demonstrated effects on the tumor microenvironment (TME) involving immunomodulation, anti-angiogenesis and inhibition of metastasis. A target molecule of tasquinimod is the inflammatory protein S100A9 which has been shown to affect the accumulation and function of suppressive myeloid cell subsets in tumors. Given the major impact of myeloid cells to the tumor microenvironment, manipulation of this cell compartment is a desirable goal in cancer therapeutics.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8504622
- author
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal for ImmunoTherapy of Cancer
- volume
- 3
- article number
- 53
- publisher
- BMJ Publishing Group
- external identifiers
-
- pmid:26673090
- wos:000367157700001
- pmid:26673090
- scopus:84997171030
- ISSN
- 2051-1426
- DOI
- 10.1186/s40425-015-0098-5
- language
- English
- LU publication?
- yes
- id
- d875efc7-419d-4bfe-a114-12db38647e20 (old id 8504622)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26673090?dopt=Abstract
- date added to LUP
- 2016-04-01 13:21:37
- date last changed
- 2022-10-27 01:20:49
@article{d875efc7-419d-4bfe-a114-12db38647e20, abstract = {{Tasquinimod (a quinoline-3-carboxyamide) is a small molecule immunotherapy with demonstrated effects on the tumor microenvironment (TME) involving immunomodulation, anti-angiogenesis and inhibition of metastasis. A target molecule of tasquinimod is the inflammatory protein S100A9 which has been shown to affect the accumulation and function of suppressive myeloid cell subsets in tumors. Given the major impact of myeloid cells to the tumor microenvironment, manipulation of this cell compartment is a desirable goal in cancer therapeutics.}}, author = {{Olsson, Anders and Nakhlé, Jessica and Sundstedt, Anette and Plas, Pascale and Bauchet, Anne-Laure and Pierron, Valérie and Bruetschy, Luce and Deronic, Adnan and Törngren, Marie and Liberg, David and Schmidlin, Fabien and Leanderson, Tomas}}, issn = {{2051-1426}}, language = {{eng}}, publisher = {{BMJ Publishing Group}}, series = {{Journal for ImmunoTherapy of Cancer}}, title = {{Tasquinimod triggers an early change in the polarization of tumor associated macrophages in the tumor microenvironment.}}, url = {{http://dx.doi.org/10.1186/s40425-015-0098-5}}, doi = {{10.1186/s40425-015-0098-5}}, volume = {{3}}, year = {{2015}}, }