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Tasquinimod triggers an early change in the polarization of tumor associated macrophages in the tumor microenvironment.

Olsson, Anders; Nakhlé, Jessica; Sundstedt, Anette; Plas, Pascale; Bauchet, Anne-Laure; Pierron, Valérie; Bruetschy, Luce; Deronic, Adnan LU ; Törngren, Marie and Liberg, David, et al. (2015) In Journal for ImmunoTherapy of Cancer 3.
Abstract
Tasquinimod (a quinoline-3-carboxyamide) is a small molecule immunotherapy with demonstrated effects on the tumor microenvironment (TME) involving immunomodulation, anti-angiogenesis and inhibition of metastasis. A target molecule of tasquinimod is the inflammatory protein S100A9 which has been shown to affect the accumulation and function of suppressive myeloid cell subsets in tumors. Given the major impact of myeloid cells to the tumor microenvironment, manipulation of this cell compartment is a desirable goal in cancer therapeutics.
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Contribution to journal
publication status
published
subject
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Journal for ImmunoTherapy of Cancer
volume
3
publisher
BioMed Central
external identifiers
  • pmid:26673090
  • wos:000367157700001
  • scopus:84997171030
ISSN
2051-1426
DOI
10.1186/s40425-015-0098-5
language
English
LU publication?
yes
id
d875efc7-419d-4bfe-a114-12db38647e20 (old id 8504622)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26673090?dopt=Abstract
date added to LUP
2016-01-05 20:14:44
date last changed
2017-10-08 03:50:28
@article{d875efc7-419d-4bfe-a114-12db38647e20,
  abstract     = {Tasquinimod (a quinoline-3-carboxyamide) is a small molecule immunotherapy with demonstrated effects on the tumor microenvironment (TME) involving immunomodulation, anti-angiogenesis and inhibition of metastasis. A target molecule of tasquinimod is the inflammatory protein S100A9 which has been shown to affect the accumulation and function of suppressive myeloid cell subsets in tumors. Given the major impact of myeloid cells to the tumor microenvironment, manipulation of this cell compartment is a desirable goal in cancer therapeutics.},
  articleno    = {53},
  author       = {Olsson, Anders and Nakhlé, Jessica and Sundstedt, Anette and Plas, Pascale and Bauchet, Anne-Laure and Pierron, Valérie and Bruetschy, Luce and Deronic, Adnan and Törngren, Marie and Liberg, David and Schmidlin, Fabien and Leanderson, Tomas},
  issn         = {2051-1426},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {Journal for ImmunoTherapy of Cancer},
  title        = {Tasquinimod triggers an early change in the polarization of tumor associated macrophages in the tumor microenvironment.},
  url          = {http://dx.doi.org/10.1186/s40425-015-0098-5},
  volume       = {3},
  year         = {2015},
}