Cyclosporin promotes neurorestoration and cell replacement therapy in pre-clinical models of Parkinson's disease.
Tamburrino, Anna ; Churchill, Madeline J ; Wan, Oi Wan LU ; Colino Sanguino, Yolanda LU ; Ippolito, Rossana ; Bergstrand, Sofie ; Wolf, Daniel LU ; Herz, Niculin J ; Sconce, Michelle D and Björklund, Anders LU
, et al.
(2015)
In Acta Neuropathologica Communications
3(1).
- Abstract
- The early clinical trials using fetal ventral mesencephalic (VM) allografts in Parkinson's disease (PD) patients have shown efficacy (albeit not in all cases) and have paved the way for further development of cell replacement therapy strategies in PD. The preclinical work that led to these clinical trials used allografts of fetal VM tissue placed into 6-OHDA lesioned rats, while the patients received similar allografts under cover of immunosuppression in an α-synuclein disease state. Thus developing models that more faithfully replicate the clinical scenario would be a useful tool for the translation of such cell-based therapies to the clinic.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8504837
- author
- Tamburrino, Anna
; Churchill, Madeline J
; Wan, Oi Wan
LU
; Colino Sanguino, Yolanda
LU
; Ippolito, Rossana
; Bergstrand, Sofie
; Wolf, Daniel
LU
; Herz, Niculin J
; Sconce, Michelle D
and Björklund, Anders
LU
, et al. (More)
- Tamburrino, Anna
; Churchill, Madeline J
; Wan, Oi Wan
LU
; Colino Sanguino, Yolanda
LU
; Ippolito, Rossana
; Bergstrand, Sofie
; Wolf, Daniel
LU
; Herz, Niculin J
; Sconce, Michelle D
; Björklund, Anders
LU
; Meshul, Charles K
and Decressac, Mickael
(Less)
- organization
- publishing date
- 2015-12-14
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Neuropathologica Communications
- volume
- 3
- issue
- 1
- article number
- 84
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:26666562
- wos:000366463400001
- scopus:84973432297
- pmid:26666562
- ISSN
- 2051-5960
- DOI
- 10.1186/s40478-015-0263-6
- language
- English
- LU publication?
- yes
- id
- dcab5aab-c5c8-483c-ad85-a4908f752f1d (old id 8504837)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26666562?dopt=Abstract
- date added to LUP
- 2016-04-01 13:32:29
- date last changed
- 2022-04-21 22:09:30
@article{dcab5aab-c5c8-483c-ad85-a4908f752f1d,
abstract = {{The early clinical trials using fetal ventral mesencephalic (VM) allografts in Parkinson's disease (PD) patients have shown efficacy (albeit not in all cases) and have paved the way for further development of cell replacement therapy strategies in PD. The preclinical work that led to these clinical trials used allografts of fetal VM tissue placed into 6-OHDA lesioned rats, while the patients received similar allografts under cover of immunosuppression in an α-synuclein disease state. Thus developing models that more faithfully replicate the clinical scenario would be a useful tool for the translation of such cell-based therapies to the clinic.}},
author = {{Tamburrino, Anna and Churchill, Madeline J and Wan, Oi Wan and Colino Sanguino, Yolanda and Ippolito, Rossana and Bergstrand, Sofie and Wolf, Daniel and Herz, Niculin J and Sconce, Michelle D and Björklund, Anders and Meshul, Charles K and Decressac, Mickael}},
issn = {{2051-5960}},
language = {{eng}},
month = {{12}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{Acta Neuropathologica Communications}},
title = {{Cyclosporin promotes neurorestoration and cell replacement therapy in pre-clinical models of Parkinson's disease.}},
url = {{http://dx.doi.org/10.1186/s40478-015-0263-6}},
doi = {{10.1186/s40478-015-0263-6}},
volume = {{3}},
year = {{2015}},
}