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Cyclosporin promotes neurorestoration and cell replacement therapy in pre-clinical models of Parkinson's disease.

Tamburrino, Anna; Churchill, Madeline J; Wan, Oi Wan LU ; Colino Sanguino, Yolanda LU ; Ippolito, Rossana; Bergstrand, Sofie; Wolf, Daniel LU ; Herz, Niculin J; Sconce, Michelle D and Björklund, Anders LU , et al. (2015) In Acta neuropathologica communications 3(1).
Abstract
The early clinical trials using fetal ventral mesencephalic (VM) allografts in Parkinson's disease (PD) patients have shown efficacy (albeit not in all cases) and have paved the way for further development of cell replacement therapy strategies in PD. The preclinical work that led to these clinical trials used allografts of fetal VM tissue placed into 6-OHDA lesioned rats, while the patients received similar allografts under cover of immunosuppression in an α-synuclein disease state. Thus developing models that more faithfully replicate the clinical scenario would be a useful tool for the translation of such cell-based therapies to the clinic.
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Acta neuropathologica communications
volume
3
issue
1
publisher
BioMed Central
external identifiers
  • pmid:26666562
  • wos:000366463400001
  • scopus:84973432297
ISSN
2051-5960
DOI
10.1186/s40478-015-0263-6
language
English
LU publication?
yes
id
dcab5aab-c5c8-483c-ad85-a4908f752f1d (old id 8504837)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26666562?dopt=Abstract
date added to LUP
2016-01-05 19:17:30
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2017-10-01 04:09:08
@article{dcab5aab-c5c8-483c-ad85-a4908f752f1d,
  abstract     = {The early clinical trials using fetal ventral mesencephalic (VM) allografts in Parkinson's disease (PD) patients have shown efficacy (albeit not in all cases) and have paved the way for further development of cell replacement therapy strategies in PD. The preclinical work that led to these clinical trials used allografts of fetal VM tissue placed into 6-OHDA lesioned rats, while the patients received similar allografts under cover of immunosuppression in an α-synuclein disease state. Thus developing models that more faithfully replicate the clinical scenario would be a useful tool for the translation of such cell-based therapies to the clinic.},
  articleno    = {84},
  author       = {Tamburrino, Anna and Churchill, Madeline J and Wan, Oi Wan and Colino Sanguino, Yolanda and Ippolito, Rossana and Bergstrand, Sofie and Wolf, Daniel and Herz, Niculin J and Sconce, Michelle D and Björklund, Anders and Meshul, Charles K and Decressac, Mickael},
  issn         = {2051-5960},
  language     = {eng},
  month        = {12},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {Acta neuropathologica communications},
  title        = {Cyclosporin promotes neurorestoration and cell replacement therapy in pre-clinical models of Parkinson's disease.},
  url          = {http://dx.doi.org/10.1186/s40478-015-0263-6},
  volume       = {3},
  year         = {2015},
}