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Risk of malignant melanoma in men with prostate cancer: Nationwide, population-based cohort study.

Thomsen, Frederik B; Folkvaljon, Yasin; Garmo, Hans; Robinson, David; Loeb, Stacy; Ingvar, Christian LU ; Lambe, Mats and Stattin, Pär (2016) In International Journal of Cancer 138(9). p.2154-2160
Abstract
An increased risk of malignant melanoma has been observed in men with prostate cancer. To assess potential shared risk factors and confounding factors, we analysed risk of melanoma in men with prostate cancer including information on tumor characteristics and demographics including socioeconomic status. In The Prostate Cancer data Base Sweden, risk of melanoma was assessed in a cohort of men with prostate cancer and in a comparison cohort of prostate-cancer free men. Data on prostate cancer risk category, melanoma stage, basal cell carcinoma, location of residency, and socioeconomic status were obtained from nationwide registers. Melanoma was diagnosed in 830/108 145 (0.78%) men with prostate cancer and in 3699/556 792 (0.66%) prostate... (More)
An increased risk of malignant melanoma has been observed in men with prostate cancer. To assess potential shared risk factors and confounding factors, we analysed risk of melanoma in men with prostate cancer including information on tumor characteristics and demographics including socioeconomic status. In The Prostate Cancer data Base Sweden, risk of melanoma was assessed in a cohort of men with prostate cancer and in a comparison cohort of prostate-cancer free men. Data on prostate cancer risk category, melanoma stage, basal cell carcinoma, location of residency, and socioeconomic status were obtained from nationwide registers. Melanoma was diagnosed in 830/108 145 (0.78%) men with prostate cancer and in 3699/556 792 (0.66%) prostate cancer-free men. In multivariable Cox regression models, men with prostate cancer had a significantly increased risk of melanoma (HR 1.18, 95% CI 1.09-1.27), and so had married men, men with high education and income, and men residing in southern Sweden. The strongest associations were observed for stage 0 melanoma in men with low-risk prostate cancer (HR 1.45, 1.14-1.86), high education (HR 1.87, 1.60-2.18), and top income (HR 1.61, 1.34-1.93), respectively, whereas there was no association between these factors and late-stage melanoma. Men with prostate cancer also had an increased risk of basal cell carcinoma (HR 1.18, 1.15-1.22). In conclusion, men with low-risk prostate cancer, high education, high income, and residency in southern Sweden had an increased risk of early-stage melanoma. This article is protected by copyright. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Cancer
volume
138
issue
9
pages
2154 - 2160
publisher
John Wiley & Sons
external identifiers
  • pmid:26662367
  • scopus:84958975133
  • wos:000371161800011
ISSN
0020-7136
DOI
10.1002/ijc.29961
language
English
LU publication?
yes
id
aae88b8c-084d-48bc-8444-fa94d900728c (old id 8504969)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26662367?dopt=Abstract
date added to LUP
2016-01-05 18:37:37
date last changed
2017-11-12 04:07:58
@article{aae88b8c-084d-48bc-8444-fa94d900728c,
  abstract     = {An increased risk of malignant melanoma has been observed in men with prostate cancer. To assess potential shared risk factors and confounding factors, we analysed risk of melanoma in men with prostate cancer including information on tumor characteristics and demographics including socioeconomic status. In The Prostate Cancer data Base Sweden, risk of melanoma was assessed in a cohort of men with prostate cancer and in a comparison cohort of prostate-cancer free men. Data on prostate cancer risk category, melanoma stage, basal cell carcinoma, location of residency, and socioeconomic status were obtained from nationwide registers. Melanoma was diagnosed in 830/108 145 (0.78%) men with prostate cancer and in 3699/556 792 (0.66%) prostate cancer-free men. In multivariable Cox regression models, men with prostate cancer had a significantly increased risk of melanoma (HR 1.18, 95% CI 1.09-1.27), and so had married men, men with high education and income, and men residing in southern Sweden. The strongest associations were observed for stage 0 melanoma in men with low-risk prostate cancer (HR 1.45, 1.14-1.86), high education (HR 1.87, 1.60-2.18), and top income (HR 1.61, 1.34-1.93), respectively, whereas there was no association between these factors and late-stage melanoma. Men with prostate cancer also had an increased risk of basal cell carcinoma (HR 1.18, 1.15-1.22). In conclusion, men with low-risk prostate cancer, high education, high income, and residency in southern Sweden had an increased risk of early-stage melanoma. This article is protected by copyright. All rights reserved.},
  author       = {Thomsen, Frederik B and Folkvaljon, Yasin and Garmo, Hans and Robinson, David and Loeb, Stacy and Ingvar, Christian and Lambe, Mats and Stattin, Pär},
  issn         = {0020-7136},
  language     = {eng},
  number       = {9},
  pages        = {2154--2160},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Risk of malignant melanoma in men with prostate cancer: Nationwide, population-based cohort study.},
  url          = {http://dx.doi.org/10.1002/ijc.29961},
  volume       = {138},
  year         = {2016},
}