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Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases.

Guerreiro, Rita; Escott-Price, Valentina; Darwent, Lee; Parkkinen, Laura; Ansorge, Olaf; Hernandez, Dena G; Nalls, Michael A; Clark, Lorraine; Honig, Lawrence and Marder, Karen, et al. (2016) In Neurobiology of Aging 38. p.7-214
Abstract
The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally... (More)
The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD. (Less)
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Neurobiology of Aging
volume
38
pages
7 - 214
publisher
Elsevier
external identifiers
  • pmid:26643944
  • wos:000368991300025
  • scopus:84948808791
ISSN
1558-1497
DOI
10.1016/j.neurobiolaging.2015.10.028
language
English
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yes
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c87e3f00-ccce-4d81-aa15-1fbeebec4d24 (old id 8505500)
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http://www.ncbi.nlm.nih.gov/pubmed/26643944?dopt=Abstract
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2016-01-05 13:51:23
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2017-09-17 03:52:23
@article{c87e3f00-ccce-4d81-aa15-1fbeebec4d24,
  abstract     = {The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD.},
  author       = {Guerreiro, Rita and Escott-Price, Valentina and Darwent, Lee and Parkkinen, Laura and Ansorge, Olaf and Hernandez, Dena G and Nalls, Michael A and Clark, Lorraine and Honig, Lawrence and Marder, Karen and van der Flier, Wiesje and Holstege, Henne and Louwersheimer, Eva and Lemstra, Afina and Scheltens, Philip and Rogaeva, Ekaterina and St George-Hyslop, Peter and Londos, Elisabet and Zetterberg, Henrik and Ortega-Cubero, Sara and Pastor, Pau and Ferman, Tanis J and Graff-Radford, Neill R and Ross, Owen A and Barber, Imelda and Braae, Anne and Brown, Kristelle and Morgan, Kevin and Maetzler, Walter and Berg, Daniela and Troakes, Claire and Al-Sarraj, Safa and Lashley, Tammaryn and Compta, Yaroslau and Revesz, Tamas and Lees, Andrew and Cairns, Nigel J and Halliday, Glenda M and Mann, David and Pickering-Brown, Stuart and Powell, John and Lunnon, Katie and Lupton, Michelle K and Dickson, Dennis and Hardy, John and Singleton, Andrew and Bras, Jose},
  issn         = {1558-1497},
  language     = {eng},
  pages        = {7--214},
  publisher    = {Elsevier},
  series       = {Neurobiology of Aging},
  title        = {Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases.},
  url          = {http://dx.doi.org/10.1016/j.neurobiolaging.2015.10.028},
  volume       = {38},
  year         = {2016},
}