Advanced

Alterations of telomere length and DNA methylation in hairdressers: A cross-sectional study.

Li, Huiqi LU ; Åkerman, Gabriella LU ; Lidén, Carola; Alhamdow, Ayman LU ; Wojdacz, Tomasz K; Broberg Palmgren, Karin LU and Albin, Maria LU (2016) In Environmental and Molecular Mutagenesis 57(2). p.159-167
Abstract
Working as hairdressers has been associated with increased risk for cancer, particularly bladder cancer. To evaluate if current hairdressers have elevated risks of adverse health effects, we measured several biomarkers related to cancer-related DNA alterations. We enrolled 295 hairdressers and 92 non-hairdressers (all female non-smokers) from Stockholm and southern Sweden. Questionnaire data were collected for each participant, including work tasks for the hairdressers. We measured telomere length in peripheral blood leucocytes using quantitative PCR and DNA methylation status of genes relevant for bladder cancer using methylation sensitive high resolution melting analysis. The hairdressers had shorter telomeres (β = -0.069, P = 0.019)... (More)
Working as hairdressers has been associated with increased risk for cancer, particularly bladder cancer. To evaluate if current hairdressers have elevated risks of adverse health effects, we measured several biomarkers related to cancer-related DNA alterations. We enrolled 295 hairdressers and 92 non-hairdressers (all female non-smokers) from Stockholm and southern Sweden. Questionnaire data were collected for each participant, including work tasks for the hairdressers. We measured telomere length in peripheral blood leucocytes using quantitative PCR and DNA methylation status of genes relevant for bladder cancer using methylation sensitive high resolution melting analysis. The hairdressers had shorter telomeres (β = -0.069, P = 0.019) compared with non-hairdressers. Shorter telomeres were found in hairdressers up to 32 years old performing hair waving more than once per week as compared with hairdressers in the same age group performing hair waving less often (β = -0.12, P = 0.037). Hair waving was associated with less frequent CDKN2A methylation (odds ratio, OR = 0.19, P = 0.033). Shorter telomeres in hairdressers may indicate a genotoxic effect. Performing hair waving was associated with short telomere length, although the effect was only observed in young hairdressers. No clear patterns were discerned with regard to DNA methylation of bladder cancer-related genes. The observed changes of methylation were not all in the expected direction and warrant further investigation. Environ. Mol. Mutagen., 2015. © 2015 Wiley Periodicals, Inc. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Environmental and Molecular Mutagenesis
volume
57
issue
2
pages
159 - 167
publisher
John Wiley & Sons
external identifiers
  • pmid:26637967
  • scopus:84957882614
  • wos:000370333500006
ISSN
1098-2280
DOI
10.1002/em.21991
language
English
LU publication?
yes
id
16cea407-ad3d-49c8-9895-135958c66ff6 (old id 8505615)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26637967?dopt=Abstract
date added to LUP
2016-01-04 22:14:15
date last changed
2017-11-05 04:45:03
@article{16cea407-ad3d-49c8-9895-135958c66ff6,
  abstract     = {Working as hairdressers has been associated with increased risk for cancer, particularly bladder cancer. To evaluate if current hairdressers have elevated risks of adverse health effects, we measured several biomarkers related to cancer-related DNA alterations. We enrolled 295 hairdressers and 92 non-hairdressers (all female non-smokers) from Stockholm and southern Sweden. Questionnaire data were collected for each participant, including work tasks for the hairdressers. We measured telomere length in peripheral blood leucocytes using quantitative PCR and DNA methylation status of genes relevant for bladder cancer using methylation sensitive high resolution melting analysis. The hairdressers had shorter telomeres (β = -0.069, P = 0.019) compared with non-hairdressers. Shorter telomeres were found in hairdressers up to 32 years old performing hair waving more than once per week as compared with hairdressers in the same age group performing hair waving less often (β = -0.12, P = 0.037). Hair waving was associated with less frequent CDKN2A methylation (odds ratio, OR = 0.19, P = 0.033). Shorter telomeres in hairdressers may indicate a genotoxic effect. Performing hair waving was associated with short telomere length, although the effect was only observed in young hairdressers. No clear patterns were discerned with regard to DNA methylation of bladder cancer-related genes. The observed changes of methylation were not all in the expected direction and warrant further investigation. Environ. Mol. Mutagen., 2015. © 2015 Wiley Periodicals, Inc.},
  author       = {Li, Huiqi and Åkerman, Gabriella and Lidén, Carola and Alhamdow, Ayman and Wojdacz, Tomasz K and Broberg Palmgren, Karin and Albin, Maria},
  issn         = {1098-2280},
  language     = {eng},
  number       = {2},
  pages        = {159--167},
  publisher    = {John Wiley & Sons},
  series       = {Environmental and Molecular Mutagenesis},
  title        = {Alterations of telomere length and DNA methylation in hairdressers: A cross-sectional study.},
  url          = {http://dx.doi.org/10.1002/em.21991},
  volume       = {57},
  year         = {2016},
}