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Grating-based X-ray Dark-field Computed Tomography of Living Mice.

Velroyen, A; Yaroshenko, A; Hahn, D; Fehringer, A; Tapfer, A; Müller, M; Noël, P B; Pauwels, B; Sasov, A and Yildirim, A Ö, et al. (2015) In EBioMedicine 2(10). p.1500-1506
Abstract
Changes in x-ray attenuating tissue caused by lung disorders like emphysema or fibrosis are subtle and thus only resolved by high-resolution computed tomography (CT). The structural reorganization, however, is of strong influence for lung function. Dark-field CT (DFCT), based on small-angle scattering of x-rays, reveals such structural changes even at resolutions coarser than the pulmonary network and thus provides access to their anatomical distribution. In this proof-of-concept study we present x-ray in vivo DFCTs of lungs of a healthy, an emphysematous and a fibrotic mouse. The tomographies show excellent depiction of the distribution of structural - and thus indirectly functional - changes in lung parenchyma, on single-modality slices... (More)
Changes in x-ray attenuating tissue caused by lung disorders like emphysema or fibrosis are subtle and thus only resolved by high-resolution computed tomography (CT). The structural reorganization, however, is of strong influence for lung function. Dark-field CT (DFCT), based on small-angle scattering of x-rays, reveals such structural changes even at resolutions coarser than the pulmonary network and thus provides access to their anatomical distribution. In this proof-of-concept study we present x-ray in vivo DFCTs of lungs of a healthy, an emphysematous and a fibrotic mouse. The tomographies show excellent depiction of the distribution of structural - and thus indirectly functional - changes in lung parenchyma, on single-modality slices in dark field as well as on multimodal fusion images. Therefore, we anticipate numerous applications of DFCT in diagnostic lung imaging. We introduce a scatter-based Hounsfield Unit (sHU) scale to facilitate comparability of scans. In this newly defined sHU scale, the pathophysiological changes by emphysema and fibrosis cause a shift towards lower numbers, compared to healthy lung tissue. (Less)
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EBioMedicine
volume
2
issue
10
pages
1500 - 1506
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Elsevier
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  • pmid:26629545
  • wos:000365959700049
  • scopus:84951904894
ISSN
2352-3964
DOI
10.1016/j.ebiom.2015.08.014
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English
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886f3761-99e2-4b6f-bf5d-1dd1a1a313a8 (old id 8505798)
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http://www.ncbi.nlm.nih.gov/pubmed/26629545?dopt=Abstract
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@article{886f3761-99e2-4b6f-bf5d-1dd1a1a313a8,
  abstract     = {Changes in x-ray attenuating tissue caused by lung disorders like emphysema or fibrosis are subtle and thus only resolved by high-resolution computed tomography (CT). The structural reorganization, however, is of strong influence for lung function. Dark-field CT (DFCT), based on small-angle scattering of x-rays, reveals such structural changes even at resolutions coarser than the pulmonary network and thus provides access to their anatomical distribution. In this proof-of-concept study we present x-ray in vivo DFCTs of lungs of a healthy, an emphysematous and a fibrotic mouse. The tomographies show excellent depiction of the distribution of structural - and thus indirectly functional - changes in lung parenchyma, on single-modality slices in dark field as well as on multimodal fusion images. Therefore, we anticipate numerous applications of DFCT in diagnostic lung imaging. We introduce a scatter-based Hounsfield Unit (sHU) scale to facilitate comparability of scans. In this newly defined sHU scale, the pathophysiological changes by emphysema and fibrosis cause a shift towards lower numbers, compared to healthy lung tissue.},
  author       = {Velroyen, A and Yaroshenko, A and Hahn, D and Fehringer, A and Tapfer, A and Müller, M and Noël, P B and Pauwels, B and Sasov, A and Yildirim, A Ö and Eickelberg, O and Hellbach, K and Auweter, S D and Meinel, F G and Reiser, M F and Bech, Martin and Pfeiffer, F},
  issn         = {2352-3964},
  language     = {eng},
  number       = {10},
  pages        = {1500--1506},
  publisher    = {Elsevier},
  series       = {EBioMedicine},
  title        = {Grating-based X-ray Dark-field Computed Tomography of Living Mice.},
  url          = {http://dx.doi.org/10.1016/j.ebiom.2015.08.014},
  volume       = {2},
  year         = {2015},
}