Grating-based X-ray Dark-field Computed Tomography of Living Mice.
(2015) In EBioMedicine 2(10). p.1500-1506- Abstract
- Changes in x-ray attenuating tissue caused by lung disorders like emphysema or fibrosis are subtle and thus only resolved by high-resolution computed tomography (CT). The structural reorganization, however, is of strong influence for lung function. Dark-field CT (DFCT), based on small-angle scattering of x-rays, reveals such structural changes even at resolutions coarser than the pulmonary network and thus provides access to their anatomical distribution. In this proof-of-concept study we present x-ray in vivo DFCTs of lungs of a healthy, an emphysematous and a fibrotic mouse. The tomographies show excellent depiction of the distribution of structural - and thus indirectly functional - changes in lung parenchyma, on single-modality slices... (More)
- Changes in x-ray attenuating tissue caused by lung disorders like emphysema or fibrosis are subtle and thus only resolved by high-resolution computed tomography (CT). The structural reorganization, however, is of strong influence for lung function. Dark-field CT (DFCT), based on small-angle scattering of x-rays, reveals such structural changes even at resolutions coarser than the pulmonary network and thus provides access to their anatomical distribution. In this proof-of-concept study we present x-ray in vivo DFCTs of lungs of a healthy, an emphysematous and a fibrotic mouse. The tomographies show excellent depiction of the distribution of structural - and thus indirectly functional - changes in lung parenchyma, on single-modality slices in dark field as well as on multimodal fusion images. Therefore, we anticipate numerous applications of DFCT in diagnostic lung imaging. We introduce a scatter-based Hounsfield Unit (sHU) scale to facilitate comparability of scans. In this newly defined sHU scale, the pathophysiological changes by emphysema and fibrosis cause a shift towards lower numbers, compared to healthy lung tissue. (Less)
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https://lup.lub.lu.se/record/8505798
- author
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- EBioMedicine
- volume
- 2
- issue
- 10
- pages
- 1500 - 1506
- publisher
- Elsevier
- external identifiers
-
- pmid:26629545
- wos:000365959700049
- scopus:84951904894
- pmid:26629545
- ISSN
- 2352-3964
- DOI
- 10.1016/j.ebiom.2015.08.014
- language
- English
- LU publication?
- yes
- id
- 886f3761-99e2-4b6f-bf5d-1dd1a1a313a8 (old id 8505798)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26629545?dopt=Abstract
- date added to LUP
- 2016-04-01 12:56:14
- date last changed
- 2022-04-13 22:17:27
@article{886f3761-99e2-4b6f-bf5d-1dd1a1a313a8, abstract = {{Changes in x-ray attenuating tissue caused by lung disorders like emphysema or fibrosis are subtle and thus only resolved by high-resolution computed tomography (CT). The structural reorganization, however, is of strong influence for lung function. Dark-field CT (DFCT), based on small-angle scattering of x-rays, reveals such structural changes even at resolutions coarser than the pulmonary network and thus provides access to their anatomical distribution. In this proof-of-concept study we present x-ray in vivo DFCTs of lungs of a healthy, an emphysematous and a fibrotic mouse. The tomographies show excellent depiction of the distribution of structural - and thus indirectly functional - changes in lung parenchyma, on single-modality slices in dark field as well as on multimodal fusion images. Therefore, we anticipate numerous applications of DFCT in diagnostic lung imaging. We introduce a scatter-based Hounsfield Unit (sHU) scale to facilitate comparability of scans. In this newly defined sHU scale, the pathophysiological changes by emphysema and fibrosis cause a shift towards lower numbers, compared to healthy lung tissue.}}, author = {{Velroyen, A and Yaroshenko, A and Hahn, D and Fehringer, A and Tapfer, A and Müller, M and Noël, P B and Pauwels, B and Sasov, A and Yildirim, A Ö and Eickelberg, O and Hellbach, K and Auweter, S D and Meinel, F G and Reiser, M F and Bech, Martin and Pfeiffer, F}}, issn = {{2352-3964}}, language = {{eng}}, number = {{10}}, pages = {{1500--1506}}, publisher = {{Elsevier}}, series = {{EBioMedicine}}, title = {{Grating-based X-ray Dark-field Computed Tomography of Living Mice.}}, url = {{http://dx.doi.org/10.1016/j.ebiom.2015.08.014}}, doi = {{10.1016/j.ebiom.2015.08.014}}, volume = {{2}}, year = {{2015}}, }