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Mycoplasma genitalium and macrolide resistance-associated mutations in the Skåne Region of Southern Sweden 2015

Forslund, Ola LU ; Hjelm, Max; El-Ali, Raghd; Johnsson, Annika LU and Bjartling, Carina LU (2017) In Acta Dermato-Venereologica 97(10). p.1235-1238
Abstract

Mycoplasma genitalium is a sexually transmitted infection ordinarily treated with azithromycin. Emerging resistance to macrolide is linked to mutations in the 23S rRNA gene. We analysed the frequency of such mutations of M. genitalium isolates from patients that were symptomatic, and from sexual partners of symptomatic individuals, from October to December of 2015, in the Skåne Region of Sweden. Mutations were analysed by the use of DNA sequencing. Overall, 11.9% (145/1,311) and 17.0% (116/704) of females and males were positive for M. genitalium, respectively. Macrolide resistant mutations were detected in 13% (31/239) of M. genitalium isolates from first-test patient samples. Twenty-one (8.8%) and 10 (4.2%) of the isolates had point... (More)

Mycoplasma genitalium is a sexually transmitted infection ordinarily treated with azithromycin. Emerging resistance to macrolide is linked to mutations in the 23S rRNA gene. We analysed the frequency of such mutations of M. genitalium isolates from patients that were symptomatic, and from sexual partners of symptomatic individuals, from October to December of 2015, in the Skåne Region of Sweden. Mutations were analysed by the use of DNA sequencing. Overall, 11.9% (145/1,311) and 17.0% (116/704) of females and males were positive for M. genitalium, respectively. Macrolide resistant mutations were detected in 13% (31/239) of M. genitalium isolates from first-test patient samples. Twenty-one (8.8%) and 10 (4.2%) of the isolates had point mutations of the 23S-gene at position 2072 and 2071, respectively. Two different M. genitalium isolates were detected simultaneously in two cases. In summary, we found a relatively low rate of macrolide-resistant M. genitalium in the region of Southern Sweden.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Azithromycin, Macrolide, Mycoplasma genitalium, Resistance
in
Acta Dermato-Venereologica
volume
97
issue
10
pages
4 pages
publisher
Medical Journals Limited
external identifiers
  • scopus:85032706592
ISSN
0001-5555
DOI
10.2340/00015555-2746
language
English
LU publication?
yes
id
852345de-f457-4bda-ac26-5a24cb41af04
date added to LUP
2017-11-22 13:10:08
date last changed
2018-01-07 12:26:31
@article{852345de-f457-4bda-ac26-5a24cb41af04,
  abstract     = {<p>Mycoplasma genitalium is a sexually transmitted infection ordinarily treated with azithromycin. Emerging resistance to macrolide is linked to mutations in the 23S rRNA gene. We analysed the frequency of such mutations of M. genitalium isolates from patients that were symptomatic, and from sexual partners of symptomatic individuals, from October to December of 2015, in the Skåne Region of Sweden. Mutations were analysed by the use of DNA sequencing. Overall, 11.9% (145/1,311) and 17.0% (116/704) of females and males were positive for M. genitalium, respectively. Macrolide resistant mutations were detected in 13% (31/239) of M. genitalium isolates from first-test patient samples. Twenty-one (8.8%) and 10 (4.2%) of the isolates had point mutations of the 23S-gene at position 2072 and 2071, respectively. Two different M. genitalium isolates were detected simultaneously in two cases. In summary, we found a relatively low rate of macrolide-resistant M. genitalium in the region of Southern Sweden.</p>},
  author       = {Forslund, Ola and Hjelm, Max and El-Ali, Raghd and Johnsson, Annika and Bjartling, Carina},
  issn         = {0001-5555},
  keyword      = {Azithromycin,Macrolide,Mycoplasma genitalium,Resistance},
  language     = {eng},
  month        = {11},
  number       = {10},
  pages        = {1235--1238},
  publisher    = {Medical Journals Limited},
  series       = {Acta Dermato-Venereologica},
  title        = {Mycoplasma genitalium and macrolide resistance-associated mutations in the Skåne Region of Southern Sweden 2015},
  url          = {http://dx.doi.org/10.2340/00015555-2746},
  volume       = {97},
  year         = {2017},
}