Exhaled oral and nasal nitric oxide during L-arginine infusion in preeclampsia
(1998) In Gynecologic and Obstetric Investigation 46(4). p.7-232- Abstract
OBJECTIVE: To determine the effects of the nitric oxide (NO) precursor L-arginine on the airway NO concentration in patients with preeclampsia.
METHODS: NO was measured by a noninvasive chemiluminescence technique in air sampled directly from nasal and oral cavities during expiration before and during L-arginine infusion in 9 preeclamptic and 10 control pregnancies. Maternal blood pressure and heart rate were simultaneously recorded, and blood was sampled for analyses of cyclic guanosine monophosphate (cGMP) and nitrate.
RESULTS: Basal nasal and orally exhaled NO and the increment in nasal NO concentration during L-arginine infusion were similar in both groups. Basal plasma and platelet cGMP concentrations were similar in... (More)
OBJECTIVE: To determine the effects of the nitric oxide (NO) precursor L-arginine on the airway NO concentration in patients with preeclampsia.
METHODS: NO was measured by a noninvasive chemiluminescence technique in air sampled directly from nasal and oral cavities during expiration before and during L-arginine infusion in 9 preeclamptic and 10 control pregnancies. Maternal blood pressure and heart rate were simultaneously recorded, and blood was sampled for analyses of cyclic guanosine monophosphate (cGMP) and nitrate.
RESULTS: Basal nasal and orally exhaled NO and the increment in nasal NO concentration during L-arginine infusion were similar in both groups. Basal plasma and platelet cGMP concentrations were similar in both groups. Following L-arginine infusion, plasma cGMP levels were significantly higher in preeclamptics (p < 0.01), while platelet cGMP was unaffected in both groups. Basal plasma nitrate was significantly higher in preeclamptics (p < 0.01), and this difference was not altered following infusion. Blood pressure and heart rate remained unaffected by the procedure in both groups.
CONCLUSIONS: Blood pressure did not decrease in the preeclamptics following L-arginine infusion, despite a significant increase in nasal NO sampled during breathhold and a concomitant increase in plasma cGMP, possibly reflecting an endogenous NO production. These results do not support the idea of a generalized decrease in NO production being a major cause of hypertension in preeclampsia.
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- author
- Grunewald, C ; Carlström, K LU ; Kumlien, G ; Ringqvist, Å LU and Lundberg, J
- publishing date
- 1998
- type
- Contribution to journal
- publication status
- published
- keywords
- Adult, Arginine/metabolism, Blood Pressure, Breath Tests, Cyclic GMP/blood, Female, Heart Rate, Humans, Luminescent Measurements, Mouth, Nitrates/blood, Nitric Oxide/analysis, Nose, Pre-Eclampsia/metabolism, Pregnancy
- in
- Gynecologic and Obstetric Investigation
- volume
- 46
- issue
- 4
- pages
- 7 - 232
- publisher
- Karger
- external identifiers
-
- scopus:0031593826
- pmid:9813440
- ISSN
- 0378-7346
- DOI
- 10.1159/000010040
- language
- English
- LU publication?
- no
- id
- 852579a8-5cf2-4ca7-b04f-a92225c1125a
- date added to LUP
- 2022-05-09 14:41:33
- date last changed
- 2024-01-03 10:45:43
@article{852579a8-5cf2-4ca7-b04f-a92225c1125a,
abstract = {{<p>OBJECTIVE: To determine the effects of the nitric oxide (NO) precursor L-arginine on the airway NO concentration in patients with preeclampsia.</p><p>METHODS: NO was measured by a noninvasive chemiluminescence technique in air sampled directly from nasal and oral cavities during expiration before and during L-arginine infusion in 9 preeclamptic and 10 control pregnancies. Maternal blood pressure and heart rate were simultaneously recorded, and blood was sampled for analyses of cyclic guanosine monophosphate (cGMP) and nitrate.</p><p>RESULTS: Basal nasal and orally exhaled NO and the increment in nasal NO concentration during L-arginine infusion were similar in both groups. Basal plasma and platelet cGMP concentrations were similar in both groups. Following L-arginine infusion, plasma cGMP levels were significantly higher in preeclamptics (p < 0.01), while platelet cGMP was unaffected in both groups. Basal plasma nitrate was significantly higher in preeclamptics (p < 0.01), and this difference was not altered following infusion. Blood pressure and heart rate remained unaffected by the procedure in both groups.</p><p>CONCLUSIONS: Blood pressure did not decrease in the preeclamptics following L-arginine infusion, despite a significant increase in nasal NO sampled during breathhold and a concomitant increase in plasma cGMP, possibly reflecting an endogenous NO production. These results do not support the idea of a generalized decrease in NO production being a major cause of hypertension in preeclampsia.</p>}},
author = {{Grunewald, C and Carlström, K and Kumlien, G and Ringqvist, Å and Lundberg, J}},
issn = {{0378-7346}},
keywords = {{Adult; Arginine/metabolism; Blood Pressure; Breath Tests; Cyclic GMP/blood; Female; Heart Rate; Humans; Luminescent Measurements; Mouth; Nitrates/blood; Nitric Oxide/analysis; Nose; Pre-Eclampsia/metabolism; Pregnancy}},
language = {{eng}},
number = {{4}},
pages = {{7--232}},
publisher = {{Karger}},
series = {{Gynecologic and Obstetric Investigation}},
title = {{Exhaled oral and nasal nitric oxide during L-arginine infusion in preeclampsia}},
url = {{http://dx.doi.org/10.1159/000010040}},
doi = {{10.1159/000010040}},
volume = {{46}},
year = {{1998}},
}