A method for subject specific estimation of aortic wall shear stress
(2009) In WSEAS Transactions on Biology and Biomedicine 6(3). p.49-57- Abstract
Wall shear stress (WSS) distribution in the human aorta is a highly interesting hemodynamic factor for atherosclerosis development. We present a magnetic resonance imaging (MRI) and computational fluid dynamics (CFD) based subject specific WSS estimation method and demonstrate it on a group of nine healthy volunteers (males age 23.6 ± 1.3 years). In all nine subjects, the aortic blood flow was simulated in a subject specific way, where the 3D segmented geometries and inflow profiles were obtained using MRI. No parameter settings were tailored using data from the nine subjects. Validation was performed by comparing CFD gained velocity with magnetic resonance imaging (MRI) velocity measurements. CFD and MRI velocity profiles were... (More)
Wall shear stress (WSS) distribution in the human aorta is a highly interesting hemodynamic factor for atherosclerosis development. We present a magnetic resonance imaging (MRI) and computational fluid dynamics (CFD) based subject specific WSS estimation method and demonstrate it on a group of nine healthy volunteers (males age 23.6 ± 1.3 years). In all nine subjects, the aortic blood flow was simulated in a subject specific way, where the 3D segmented geometries and inflow profiles were obtained using MRI. No parameter settings were tailored using data from the nine subjects. Validation was performed by comparing CFD gained velocity with magnetic resonance imaging (MRI) velocity measurements. CFD and MRI velocity profiles were comparable, but the temporal variations of the differences during the cardiac cycle were significant. Spatio-temporal analyzes on the WSS distribution showed a strong subject specific influence. Subject specific models are decisive to estimate WSS distribution.
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- author
- Renner, Johan ; Gårdhagen, Roland ; Ebbers, Tino ; Heiberg, Einar LU ; Länne, Toste and Karlsson, Matts
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- 3D segmentation, Aorta, CFD, MRI, Subject specific, Velocity validation, WSS
- in
- WSEAS Transactions on Biology and Biomedicine
- volume
- 6
- issue
- 3
- pages
- 49 - 57
- publisher
- World Scientific and Engineering Academy and Society
- external identifiers
-
- scopus:77951553343
- ISSN
- 1109-9518
- language
- English
- LU publication?
- yes
- id
- 8526d311-624a-4544-aace-8e23d7fbbaf4
- alternative location
- http://www.wseas.us/e-library/transactions/biology/2009/32-559.pdf
- date added to LUP
- 2022-10-21 10:22:19
- date last changed
- 2022-10-21 17:00:21
@article{8526d311-624a-4544-aace-8e23d7fbbaf4, abstract = {{<p>Wall shear stress (WSS) distribution in the human aorta is a highly interesting hemodynamic factor for atherosclerosis development. We present a magnetic resonance imaging (MRI) and computational fluid dynamics (CFD) based subject specific WSS estimation method and demonstrate it on a group of nine healthy volunteers (males age 23.6 ± 1.3 years). In all nine subjects, the aortic blood flow was simulated in a subject specific way, where the 3D segmented geometries and inflow profiles were obtained using MRI. No parameter settings were tailored using data from the nine subjects. Validation was performed by comparing CFD gained velocity with magnetic resonance imaging (MRI) velocity measurements. CFD and MRI velocity profiles were comparable, but the temporal variations of the differences during the cardiac cycle were significant. Spatio-temporal analyzes on the WSS distribution showed a strong subject specific influence. Subject specific models are decisive to estimate WSS distribution.</p>}}, author = {{Renner, Johan and Gårdhagen, Roland and Ebbers, Tino and Heiberg, Einar and Länne, Toste and Karlsson, Matts}}, issn = {{1109-9518}}, keywords = {{3D segmentation; Aorta; CFD; MRI; Subject specific; Velocity validation; WSS}}, language = {{eng}}, number = {{3}}, pages = {{49--57}}, publisher = {{World Scientific and Engineering Academy and Society}}, series = {{WSEAS Transactions on Biology and Biomedicine}}, title = {{A method for subject specific estimation of aortic wall shear stress}}, url = {{http://www.wseas.us/e-library/transactions/biology/2009/32-559.pdf}}, volume = {{6}}, year = {{2009}}, }