Is p-tert-butylphenol-formaldehyde resin (PTBP-FR) in TRUE Test (R) (Mekos test) sensitizing the tested patients?
(2015) In Contact Dermatitis 73(6). p.350-357- Abstract
- Background. In a population study using TRUE Test (R), we noted late reactions to p-tert-butylphenol-formaldehyde resin (PTBP-FR) in 0.5% of subjects tested. Objectives. In order to explore possible test sensitization, differences in the contents of sensitizers within PTBP-FR in test preparations for TRUE Test (R) and Finn Chambers (R) were analysed. Subjects allergic to PTBP-FR and subjects with late reactions to PTBP-FR were retested in order to explore whether these groups reacted to different PTBP-FR sensitizers. Pallents/materials/methods. Four individuals with late reactions and 5 subjects with established allergy to PTBP-FR were retested with defined PTBP-FR sensitizers. PTBP-FR constituents in patches from TRUE Test (R) were... (More)
- Background. In a population study using TRUE Test (R), we noted late reactions to p-tert-butylphenol-formaldehyde resin (PTBP-FR) in 0.5% of subjects tested. Objectives. In order to explore possible test sensitization, differences in the contents of sensitizers within PTBP-FR in test preparations for TRUE Test (R) and Finn Chambers (R) were analysed. Subjects allergic to PTBP-FR and subjects with late reactions to PTBP-FR were retested in order to explore whether these groups reacted to different PTBP-FR sensitizers. Pallents/materials/methods. Four individuals with late reactions and 5 subjects with established allergy to PTBP-FR were retested with defined PTBP-FR sensitizers. PTBP-FR constituents in patches from TRUE Test (R) were analysed with high-performance liquid chromatography. Previously analysed samples of PTBP-FR constituents served as a reference. Results. The pattern of reaction to PTBP-FR sensitizers was similar in both groups. Subjects with suspected sensitization had somewhat stronger reactions than controls. The concentrations of monomers, dimers and trimers were generally higher in the TRUE Test (R) resin than in reference substances. Conclusions. Retesting did not add information regarding causes of possible sensitization. Analysis showed that the resin used in TRUE Test (R) has a lower degree of polymerization or condensation, which may enhance its sensitizing properties. A follow-up of late reactions to PTBP-FR in TRUE Test (R) should be carried out. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8545729
- author
- Stenberg, Berndt ; Bruze, Magnus LU and Zimerson, Erik LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- active sensitization, late reactions, retesting
- in
- Contact Dermatitis
- volume
- 73
- issue
- 6
- pages
- 350 - 357
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000367197500005
- scopus:84955202628
- pmid:25903478
- ISSN
- 0105-1873
- DOI
- 10.1111/cod.12401
- language
- English
- LU publication?
- yes
- id
- 42072aac-ad5a-45fd-aa9d-b45f4f9c5f8e (old id 8545729)
- date added to LUP
- 2016-04-01 10:56:17
- date last changed
- 2022-07-29 03:32:11
@article{42072aac-ad5a-45fd-aa9d-b45f4f9c5f8e, abstract = {{Background. In a population study using TRUE Test (R), we noted late reactions to p-tert-butylphenol-formaldehyde resin (PTBP-FR) in 0.5% of subjects tested. Objectives. In order to explore possible test sensitization, differences in the contents of sensitizers within PTBP-FR in test preparations for TRUE Test (R) and Finn Chambers (R) were analysed. Subjects allergic to PTBP-FR and subjects with late reactions to PTBP-FR were retested in order to explore whether these groups reacted to different PTBP-FR sensitizers. Pallents/materials/methods. Four individuals with late reactions and 5 subjects with established allergy to PTBP-FR were retested with defined PTBP-FR sensitizers. PTBP-FR constituents in patches from TRUE Test (R) were analysed with high-performance liquid chromatography. Previously analysed samples of PTBP-FR constituents served as a reference. Results. The pattern of reaction to PTBP-FR sensitizers was similar in both groups. Subjects with suspected sensitization had somewhat stronger reactions than controls. The concentrations of monomers, dimers and trimers were generally higher in the TRUE Test (R) resin than in reference substances. Conclusions. Retesting did not add information regarding causes of possible sensitization. Analysis showed that the resin used in TRUE Test (R) has a lower degree of polymerization or condensation, which may enhance its sensitizing properties. A follow-up of late reactions to PTBP-FR in TRUE Test (R) should be carried out.}}, author = {{Stenberg, Berndt and Bruze, Magnus and Zimerson, Erik}}, issn = {{0105-1873}}, keywords = {{active sensitization; late reactions; retesting}}, language = {{eng}}, number = {{6}}, pages = {{350--357}}, publisher = {{Wiley-Blackwell}}, series = {{Contact Dermatitis}}, title = {{Is p-tert-butylphenol-formaldehyde resin (PTBP-FR) in TRUE Test (R) (Mekos test) sensitizing the tested patients?}}, url = {{http://dx.doi.org/10.1111/cod.12401}}, doi = {{10.1111/cod.12401}}, volume = {{73}}, year = {{2015}}, }