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Is p-tert-butylphenol-formaldehyde resin (PTBP-FR) in TRUE Test (R) (Mekos test) sensitizing the tested patients?

Stenberg, Berndt; Bruze, Magnus LU and Zimerson, Erik LU (2015) In Contact Dermatitis 73(6). p.350-357
Abstract
Background. In a population study using TRUE Test (R), we noted late reactions to p-tert-butylphenol-formaldehyde resin (PTBP-FR) in 0.5% of subjects tested. Objectives. In order to explore possible test sensitization, differences in the contents of sensitizers within PTBP-FR in test preparations for TRUE Test (R) and Finn Chambers (R) were analysed. Subjects allergic to PTBP-FR and subjects with late reactions to PTBP-FR were retested in order to explore whether these groups reacted to different PTBP-FR sensitizers. Pallents/materials/methods. Four individuals with late reactions and 5 subjects with established allergy to PTBP-FR were retested with defined PTBP-FR sensitizers. PTBP-FR constituents in patches from TRUE Test (R) were... (More)
Background. In a population study using TRUE Test (R), we noted late reactions to p-tert-butylphenol-formaldehyde resin (PTBP-FR) in 0.5% of subjects tested. Objectives. In order to explore possible test sensitization, differences in the contents of sensitizers within PTBP-FR in test preparations for TRUE Test (R) and Finn Chambers (R) were analysed. Subjects allergic to PTBP-FR and subjects with late reactions to PTBP-FR were retested in order to explore whether these groups reacted to different PTBP-FR sensitizers. Pallents/materials/methods. Four individuals with late reactions and 5 subjects with established allergy to PTBP-FR were retested with defined PTBP-FR sensitizers. PTBP-FR constituents in patches from TRUE Test (R) were analysed with high-performance liquid chromatography. Previously analysed samples of PTBP-FR constituents served as a reference. Results. The pattern of reaction to PTBP-FR sensitizers was similar in both groups. Subjects with suspected sensitization had somewhat stronger reactions than controls. The concentrations of monomers, dimers and trimers were generally higher in the TRUE Test (R) resin than in reference substances. Conclusions. Retesting did not add information regarding causes of possible sensitization. Analysis showed that the resin used in TRUE Test (R) has a lower degree of polymerization or condensation, which may enhance its sensitizing properties. A follow-up of late reactions to PTBP-FR in TRUE Test (R) should be carried out. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
active sensitization, late reactions, retesting
in
Contact Dermatitis
volume
73
issue
6
pages
350 - 357
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000367197500005
  • scopus:84955202628
ISSN
0105-1873
DOI
10.1111/cod.12401
language
English
LU publication?
yes
id
42072aac-ad5a-45fd-aa9d-b45f4f9c5f8e (old id 8545729)
date added to LUP
2016-02-08 07:21:01
date last changed
2017-11-05 03:21:16
@article{42072aac-ad5a-45fd-aa9d-b45f4f9c5f8e,
  abstract     = {Background. In a population study using TRUE Test (R), we noted late reactions to p-tert-butylphenol-formaldehyde resin (PTBP-FR) in 0.5% of subjects tested. Objectives. In order to explore possible test sensitization, differences in the contents of sensitizers within PTBP-FR in test preparations for TRUE Test (R) and Finn Chambers (R) were analysed. Subjects allergic to PTBP-FR and subjects with late reactions to PTBP-FR were retested in order to explore whether these groups reacted to different PTBP-FR sensitizers. Pallents/materials/methods. Four individuals with late reactions and 5 subjects with established allergy to PTBP-FR were retested with defined PTBP-FR sensitizers. PTBP-FR constituents in patches from TRUE Test (R) were analysed with high-performance liquid chromatography. Previously analysed samples of PTBP-FR constituents served as a reference. Results. The pattern of reaction to PTBP-FR sensitizers was similar in both groups. Subjects with suspected sensitization had somewhat stronger reactions than controls. The concentrations of monomers, dimers and trimers were generally higher in the TRUE Test (R) resin than in reference substances. Conclusions. Retesting did not add information regarding causes of possible sensitization. Analysis showed that the resin used in TRUE Test (R) has a lower degree of polymerization or condensation, which may enhance its sensitizing properties. A follow-up of late reactions to PTBP-FR in TRUE Test (R) should be carried out.},
  author       = {Stenberg, Berndt and Bruze, Magnus and Zimerson, Erik},
  issn         = {0105-1873},
  keyword      = {active sensitization,late reactions,retesting},
  language     = {eng},
  number       = {6},
  pages        = {350--357},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Is p-tert-butylphenol-formaldehyde resin (PTBP-FR) in TRUE Test (R) (Mekos test) sensitizing the tested patients?},
  url          = {http://dx.doi.org/10.1111/cod.12401},
  volume       = {73},
  year         = {2015},
}