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Causality assessment of circulating Vitamin D level on venous thromboembolism : A Mendelian randomization study

Zhang, Xiaoyu ; Sun, Wen ; Li, Ning ; Jian, Xuening ; Geng, Tao ; Wu, Lijuan ; Wang, Youxin ; Wang, Baoguo and Zheng, Deqiang LU (2023) In Nutrition, Metabolism and Cardiovascular Diseases 33(9). p.1800-1807
Abstract

Background and aims: The associations of vitamin D level with venous thromboembolism (VTE) reported in observational studies, whereas these causal associations were uncertain in European population. Therefore, we used Mendelian randomization (MR) method to explore the causal associations between 25-hydroxyvitamin D (25(OH)D) concentrations and the risk of VTE and its subtypes [including deep vein thrombosis (DVT) and pulmonary embolism (PE)]. Methods and results: We used three kinds of genetic instruments to proxy the exposure of 25(OH)D, including genetic variants significantly associated with 25(OH)D, expression quantitative trait loci of 25(OH)D target genes, and genetic variants within or nearby 25(OH)D target genes. MR analyses did... (More)

Background and aims: The associations of vitamin D level with venous thromboembolism (VTE) reported in observational studies, whereas these causal associations were uncertain in European population. Therefore, we used Mendelian randomization (MR) method to explore the causal associations between 25-hydroxyvitamin D (25(OH)D) concentrations and the risk of VTE and its subtypes [including deep vein thrombosis (DVT) and pulmonary embolism (PE)]. Methods and results: We used three kinds of genetic instruments to proxy the exposure of 25(OH)D, including genetic variants significantly associated with 25(OH)D, expression quantitative trait loci of 25(OH)D target genes, and genetic variants within or nearby 25(OH)D target genes. MR analyses did not provide any evidence for the associations of 25(OH)D levels with VTE and its subtypes (p > 0.05). The summary-data-based MR (SMR) analyses indicated that elevated expression of VDR was associated with decreased risk of VTE (OR = 0.81; 95% CI, 0.65–0.998; p = 0.047) and PE (OR = 0.67; 95% CI, 0.50–0.91; p = 0.011), and expression of AMDHD1 was associated with PE (OR = 0.93; 95% CI, 0.88–0.99; p = 0.027). MR analysis provided a significant causal effect of 25(OH)D level mediated by gene AMDHD1 on PE risk (OR = 0.09; 95% CI, 0.01–0.60; p = 0.012). Conclusion: Our MR analysis did not support causal association of 25(OH)D level with the risk of VTE and its subtypes. In addition, the expression of VDR and AMDHD1 involved in vitamin D metabolism showed a strong association with VTE or PE and might represent targets for these conditions.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Causality, eQTLs, Mendelian randomization, Venous thromboembolism, Vitamin D
in
Nutrition, Metabolism and Cardiovascular Diseases
volume
33
issue
9
pages
8 pages
publisher
Elsevier
external identifiers
  • pmid:37414665
  • scopus:85164533704
ISSN
0939-4753
DOI
10.1016/j.numecd.2023.05.019
language
English
LU publication?
yes
id
8545aa1b-e395-4167-ae2e-c431331f9c3e
date added to LUP
2023-10-09 11:44:28
date last changed
2024-04-19 02:07:27
@article{8545aa1b-e395-4167-ae2e-c431331f9c3e,
  abstract     = {{<p>Background and aims: The associations of vitamin D level with venous thromboembolism (VTE) reported in observational studies, whereas these causal associations were uncertain in European population. Therefore, we used Mendelian randomization (MR) method to explore the causal associations between 25-hydroxyvitamin D (25(OH)D) concentrations and the risk of VTE and its subtypes [including deep vein thrombosis (DVT) and pulmonary embolism (PE)]. Methods and results: We used three kinds of genetic instruments to proxy the exposure of 25(OH)D, including genetic variants significantly associated with 25(OH)D, expression quantitative trait loci of 25(OH)D target genes, and genetic variants within or nearby 25(OH)D target genes. MR analyses did not provide any evidence for the associations of 25(OH)D levels with VTE and its subtypes (p &gt; 0.05). The summary-data-based MR (SMR) analyses indicated that elevated expression of VDR was associated with decreased risk of VTE (OR = 0.81; 95% CI, 0.65–0.998; p = 0.047) and PE (OR = 0.67; 95% CI, 0.50–0.91; p = 0.011), and expression of AMDHD1 was associated with PE (OR = 0.93; 95% CI, 0.88–0.99; p = 0.027). MR analysis provided a significant causal effect of 25(OH)D level mediated by gene AMDHD1 on PE risk (OR = 0.09; 95% CI, 0.01–0.60; p = 0.012). Conclusion: Our MR analysis did not support causal association of 25(OH)D level with the risk of VTE and its subtypes. In addition, the expression of VDR and AMDHD1 involved in vitamin D metabolism showed a strong association with VTE or PE and might represent targets for these conditions.</p>}},
  author       = {{Zhang, Xiaoyu and Sun, Wen and Li, Ning and Jian, Xuening and Geng, Tao and Wu, Lijuan and Wang, Youxin and Wang, Baoguo and Zheng, Deqiang}},
  issn         = {{0939-4753}},
  keywords     = {{Causality; eQTLs; Mendelian randomization; Venous thromboembolism; Vitamin D}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{1800--1807}},
  publisher    = {{Elsevier}},
  series       = {{Nutrition, Metabolism and Cardiovascular Diseases}},
  title        = {{Causality assessment of circulating Vitamin D level on venous thromboembolism : A Mendelian randomization study}},
  url          = {{http://dx.doi.org/10.1016/j.numecd.2023.05.019}},
  doi          = {{10.1016/j.numecd.2023.05.019}},
  volume       = {{33}},
  year         = {{2023}},
}