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An integrated Biobank in the Swedish Heart Failure Registry - clinomics, proteomics, transcriptomics and genomics

Hage, Camilla ; Andersson, Therese ; Christersson, Christina ; Linde, Cecilia ; Lund, Lars H ; Karlström, Patric ; Chatziapostolou, Dina LU ; Dagner, Viveka ; Granström, Frida and Gylling, Anette , et al. (2026) In ESC Heart Failure 13(2). p.1-11
Abstract

AIMS: To build a comprehensive biobank integrated in the Swedish Heart Failure Registry (SwedeHF) comprising comprehensive clinomic data, proteomic, transcriptomic and genomic information in combination with clinical and diagnostic characteristics and additional ICD-code registry data.

METHODS: Blood and urine samples will be biobanked at SwedeHF registration with an optional second sampling after six months in patients with HF attending routine clinical visits at nine hospitals with access to healthcare integrated biobanking. Circulating and urine biomarkers will be investigated by proteomic, metabolomic, transcriptomic profiling, explored with genetic data. Sample size assessments were based on the BIOSTAT-CHF cohort and doubled... (More)

AIMS: To build a comprehensive biobank integrated in the Swedish Heart Failure Registry (SwedeHF) comprising comprehensive clinomic data, proteomic, transcriptomic and genomic information in combination with clinical and diagnostic characteristics and additional ICD-code registry data.

METHODS: Blood and urine samples will be biobanked at SwedeHF registration with an optional second sampling after six months in patients with HF attending routine clinical visits at nine hospitals with access to healthcare integrated biobanking. Circulating and urine biomarkers will be investigated by proteomic, metabolomic, transcriptomic profiling, explored with genetic data. Sample size assessments were based on the BIOSTAT-CHF cohort and doubled to fulfil all aims targeting 5000 patients.

RESULTS: The first 1348 enrolled patients were median 72 years, 30% females, 65% HFrEF and 11% HFpEF. Median NT-proBNP was 1240 (interquartile range 470 - 2830) pg/ml. This was comparable to the 8506 patients with an index registration in SwedeHF during 2023 with 52% HFrEF and 20% HFpEF, age 75 years, 36% females and NT-proBNP 1560 [629 - 3617] pg/ml.

CONCLUSIONS: We are building a high-quality detailed biobank linked to SwedeHF, the world's largest continuous HF registry, consisting of plasma, serum, whole blood and urine samples. The Biobank will enable studies exploring underlying disease mechanisms in HF and response to HF treatment, paving the way for precision medicine and novel drug targets. It will also generate a structure for biobanking in Registry-based Randomized Controlled Trials within the national SwedeHF registry.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
ESC Heart Failure
volume
13
issue
2
article number
xvag092
pages
1 - 11
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:41961636
ISSN
2055-5822
DOI
10.1093/eschf/xvag092
language
English
LU publication?
yes
additional info
© The Author(s) 2026. Published by Oxford University Press on behalf of the European Society of Cardiology.
id
854697a3-ef51-45f2-9174-8e507013a49b
date added to LUP
2026-04-13 10:54:25
date last changed
2026-04-13 14:38:34
@article{854697a3-ef51-45f2-9174-8e507013a49b,
  abstract     = {{<p>AIMS: To build a comprehensive biobank integrated in the Swedish Heart Failure Registry (SwedeHF) comprising comprehensive clinomic data, proteomic, transcriptomic and genomic information in combination with clinical and diagnostic characteristics and additional ICD-code registry data.</p><p>METHODS: Blood and urine samples will be biobanked at SwedeHF registration with an optional second sampling after six months in patients with HF attending routine clinical visits at nine hospitals with access to healthcare integrated biobanking. Circulating and urine biomarkers will be investigated by proteomic, metabolomic, transcriptomic profiling, explored with genetic data. Sample size assessments were based on the BIOSTAT-CHF cohort and doubled to fulfil all aims targeting 5000 patients.</p><p>RESULTS: The first 1348 enrolled patients were median 72 years, 30% females, 65% HFrEF and 11% HFpEF. Median NT-proBNP was 1240 (interquartile range 470 - 2830) pg/ml. This was comparable to the 8506 patients with an index registration in SwedeHF during 2023 with 52% HFrEF and 20% HFpEF, age 75 years, 36% females and NT-proBNP 1560 [629 - 3617] pg/ml.</p><p>CONCLUSIONS: We are building a high-quality detailed biobank linked to SwedeHF, the world's largest continuous HF registry, consisting of plasma, serum, whole blood and urine samples. The Biobank will enable studies exploring underlying disease mechanisms in HF and response to HF treatment, paving the way for precision medicine and novel drug targets. It will also generate a structure for biobanking in Registry-based Randomized Controlled Trials within the national SwedeHF registry.</p>}},
  author       = {{Hage, Camilla and Andersson, Therese and Christersson, Christina and Linde, Cecilia and Lund, Lars H and Karlström, Patric and Chatziapostolou, Dina and Dagner, Viveka and Granström, Frida and Gylling, Anette and Jonsson, Åsa and Haglund, Pernilla and Högberg, Jenny and Odenstedt, Annika and Viklund, Ulrika and Magnusson, Martin and Smith, J Gustav and Szabó-Söderberg, Barna and Östgärd Thunström, Erik and Dahlström, Ulf}},
  issn         = {{2055-5822}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{2}},
  pages        = {{1--11}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{ESC Heart Failure}},
  title        = {{An integrated Biobank in the Swedish Heart Failure Registry - clinomics, proteomics, transcriptomics and genomics}},
  url          = {{http://dx.doi.org/10.1093/eschf/xvag092}},
  doi          = {{10.1093/eschf/xvag092}},
  volume       = {{13}},
  year         = {{2026}},
}