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Emerging role of SOX11 in mantle cell lymphoma

Kuci, Venera LU ; Nordström, Lena LU ; Jerkeman, Mats LU and Ek, Sara LU (2015) In Blood and Lymphatic Cancer: Targets and Therapy 5. p.35-41
Abstract
During recent years the neural transcription factor SOX11 has been established as an important biomarker for mantle cell lymphoma. SOX11 is both a diagnostic and prognostic antigen, and may potentially be used for treatment selection for younger patients, in relation to protocols including high dose chemotherapy. The molecular pathways involved are still not fully elucidated and, as SOX11 can interact with several co-transcription factors, functional assays need to be carefully designed to pinpoint SOX11-specific function in a defined cellular context. Furthermore, as SOX11 belongs to a large family of homologous proteins, analysis of SOX11 has been limited by the availability of specific antibodies for detection and pull-down. In this... (More)
During recent years the neural transcription factor SOX11 has been established as an important biomarker for mantle cell lymphoma. SOX11 is both a diagnostic and prognostic antigen, and may potentially be used for treatment selection for younger patients, in relation to protocols including high dose chemotherapy. The molecular pathways involved are still not fully elucidated and, as SOX11 can interact with several co-transcription factors, functional assays need to be carefully designed to pinpoint SOX11-specific function in a defined cellular context. Furthermore, as SOX11 belongs to a large family of homologous proteins, analysis of SOX11 has been limited by the availability of specific antibodies for detection and pull-down. In this review, we discuss the emerging role of SOX11 in mantle cell lymphoma and discuss the potential impact in relation to tumorigenesis, diagnostics, prognostics, and therapy. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
SOX11, mantle cell lymphoma, diagnostic
in
Blood and Lymphatic Cancer: Targets and Therapy
volume
5
pages
35 - 41
publisher
Dove Press
external identifiers
  • wos:000366112100002
ISSN
1179-9889
DOI
10.2147/BLCTT.S60447
language
English
LU publication?
yes
id
abcebe2a-7a29-4587-8964-d7be407ae3d4 (old id 8560072)
date added to LUP
2016-01-29 11:53:55
date last changed
2016-09-30 05:43:56
@article{abcebe2a-7a29-4587-8964-d7be407ae3d4,
  abstract     = {During recent years the neural transcription factor SOX11 has been established as an important biomarker for mantle cell lymphoma. SOX11 is both a diagnostic and prognostic antigen, and may potentially be used for treatment selection for younger patients, in relation to protocols including high dose chemotherapy. The molecular pathways involved are still not fully elucidated and, as SOX11 can interact with several co-transcription factors, functional assays need to be carefully designed to pinpoint SOX11-specific function in a defined cellular context. Furthermore, as SOX11 belongs to a large family of homologous proteins, analysis of SOX11 has been limited by the availability of specific antibodies for detection and pull-down. In this review, we discuss the emerging role of SOX11 in mantle cell lymphoma and discuss the potential impact in relation to tumorigenesis, diagnostics, prognostics, and therapy.},
  author       = {Kuci, Venera and Nordström, Lena and Jerkeman, Mats and Ek, Sara},
  issn         = {1179-9889},
  keyword      = {SOX11,mantle cell lymphoma,diagnostic},
  language     = {eng},
  pages        = {35--41},
  publisher    = {Dove Press},
  series       = {Blood and Lymphatic Cancer: Targets and Therapy},
  title        = {Emerging role of SOX11 in mantle cell lymphoma},
  url          = {http://dx.doi.org/10.2147/BLCTT.S60447},
  volume       = {5},
  year         = {2015},
}