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GABAB receptors within the ventral tegmental area are involved in the expression and acquisition of morphine-induced place preference in morphine-sensitized rats

Sahraei, Hedayat; Etemadi, Leila LU ; Rostami, Parvin; Pourmotabbed, Ali; Zarrindast, Mohammad-Reza; Shams, Jamal; Ghoshooni, Hassan; Noroozzadeh, Ali; Esfandiari, Behnaz and Hossein, Seyed (2009) In Pharmacology, Biochemistry and Behavior 91(3). p.409-416
Abstract
The influence of intra-ventral tegmental area administration of gamma-amino-butyric-acid-B (GABAB) receptor agonist and antagonist on the expression and acquisition of morphine-induced conditioned place preference (CPP) in morphine-sensitized female rats was examined. Our pilot experiment showed that subcutaneous administration of morphine-(2.5, 5 and 7.5 mg/kg) induced CPP. Administration of one dose daily morphine (5 mg/kg) for 3 days followed by 5 days rest, enhanced the conditioning induced by ineffective doses of morphine (0.25, 0.5 and 1 mg/kg). Injections of GABAB receptor agonist, baclofen, (1.5 and 12 μg/rat) reduced the expression of morphine CPP whereas the dose of 6 μg/rat of the drug increased it. Baclofen also significantly... (More)
The influence of intra-ventral tegmental area administration of gamma-amino-butyric-acid-B (GABAB) receptor agonist and antagonist on the expression and acquisition of morphine-induced conditioned place preference (CPP) in morphine-sensitized female rats was examined. Our pilot experiment showed that subcutaneous administration of morphine-(2.5, 5 and 7.5 mg/kg) induced CPP. Administration of one dose daily morphine (5 mg/kg) for 3 days followed by 5 days rest, enhanced the conditioning induced by ineffective doses of morphine (0.25, 0.5 and 1 mg/kg). Injections of GABAB receptor agonist, baclofen, (1.5 and 12 μg/rat) reduced the expression of morphine CPP whereas the dose of 6 μg/rat of the drug increased it. Baclofen also significantly reduced the acquisition of morphine CPP in morphine-sensitized animals. Administration of GABAB receptor antagonist, CGP 35348, significantly reduced the expression (12 μg/rat) and acquisition (1.5, 6 and 12 μg/rat) of morphine CPP in morphine-sensitized animals.

In conclusion, results confirmed the importance of GABAB receptors within the ventral tegmental area of morphine CPP in morphine-sensitized female rats. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Sensitization, Morphine, GABAB receptor subtypes, Conditioned place preference, Rat
in
Pharmacology, Biochemistry and Behavior
volume
91
issue
3
pages
409 - 416
publisher
Elsevier
external identifiers
  • scopus:57449102153
ISSN
1873-5177
DOI
10.1016/j.pbb.2008.08.015
language
English
LU publication?
no
id
ab9f354e-9b25-49e9-a447-a9175551fe00 (old id 8569564)
date added to LUP
2016-01-28 09:09:00
date last changed
2017-07-23 03:55:18
@article{ab9f354e-9b25-49e9-a447-a9175551fe00,
  abstract     = {The influence of intra-ventral tegmental area administration of gamma-amino-butyric-acid-B (GABAB) receptor agonist and antagonist on the expression and acquisition of morphine-induced conditioned place preference (CPP) in morphine-sensitized female rats was examined. Our pilot experiment showed that subcutaneous administration of morphine-(2.5, 5 and 7.5 mg/kg) induced CPP. Administration of one dose daily morphine (5 mg/kg) for 3 days followed by 5 days rest, enhanced the conditioning induced by ineffective doses of morphine (0.25, 0.5 and 1 mg/kg). Injections of GABAB receptor agonist, baclofen, (1.5 and 12 μg/rat) reduced the expression of morphine CPP whereas the dose of 6 μg/rat of the drug increased it. Baclofen also significantly reduced the acquisition of morphine CPP in morphine-sensitized animals. Administration of GABAB receptor antagonist, CGP 35348, significantly reduced the expression (12 μg/rat) and acquisition (1.5, 6 and 12 μg/rat) of morphine CPP in morphine-sensitized animals.<br/><br>
In conclusion, results confirmed the importance of GABAB receptors within the ventral tegmental area of morphine CPP in morphine-sensitized female rats.},
  author       = {Sahraei, Hedayat and Etemadi, Leila and Rostami, Parvin and Pourmotabbed, Ali and Zarrindast, Mohammad-Reza and Shams, Jamal and Ghoshooni, Hassan and Noroozzadeh, Ali and Esfandiari, Behnaz and Hossein, Seyed},
  issn         = {1873-5177},
  keyword      = {Sensitization,Morphine,GABAB receptor subtypes,Conditioned place preference,Rat},
  language     = {eng},
  number       = {3},
  pages        = {409--416},
  publisher    = {Elsevier},
  series       = {Pharmacology, Biochemistry and Behavior},
  title        = {GABAB receptors within the ventral tegmental area are involved in the expression and acquisition of morphine-induced place preference in morphine-sensitized rats},
  url          = {http://dx.doi.org/10.1016/j.pbb.2008.08.015},
  volume       = {91},
  year         = {2009},
}