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Fetal and neonatal alloimmune thrombocytopenia.

Zdravic, Darko; Yougbare, Issaka; Vadasz, Brian; Li, Conglei; Marshall, Alexandra H; Chen, Pingguo; Kjeldsen-Kragh, Jens LU and Ni, Heyu (2016) In Seminars in Fetal & Neonatal Medicine 21(1). p.19-27
Abstract
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is an alloimmune disorder resulting from platelet opsonization by maternal antibodies that destroy fetal platelets. The major risk of FNAIT is severe bleeding, particularly intracranial hemorrhage. Miscarriage has also been reported but the incidence requires further study. Analogous to adult autoimmune thrombocytopenia (ITP), the major target antigen in FNAIT is the platelet membrane glycoprotein (GP)IIbIIIa. FNAIT caused by antibodies against platelet GPIbα or other antigens has also been reported, but the reported incidence of the anti-GPIbα-mediated FNAIT is far lower than in ITP. To date, the maternal immune response to fetal platelet antigens is still not well understood and it... (More)
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is an alloimmune disorder resulting from platelet opsonization by maternal antibodies that destroy fetal platelets. The major risk of FNAIT is severe bleeding, particularly intracranial hemorrhage. Miscarriage has also been reported but the incidence requires further study. Analogous to adult autoimmune thrombocytopenia (ITP), the major target antigen in FNAIT is the platelet membrane glycoprotein (GP)IIbIIIa. FNAIT caused by antibodies against platelet GPIbα or other antigens has also been reported, but the reported incidence of the anti-GPIbα-mediated FNAIT is far lower than in ITP. To date, the maternal immune response to fetal platelet antigens is still not well understood and it is unclear why bleeding is more severe in FNAIT than in ITP. In this review, we introduce the pathogenesis of FNAIT, particularly those new discoveries from animal models, and discuss possible improvements for the diagnosis, therapy, and prevention of this devastating disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Antibody-induced immune suppression, Fetal and neonatal alloimmune thrombocytopenia, Intraveneous immunoglobulin G, Platelets
in
Seminars in Fetal & Neonatal Medicine
volume
21
issue
1
pages
19 - 27
publisher
Elsevier
external identifiers
  • pmid:26810319
  • scopus:84957439805
  • wos:000370906100004
ISSN
1878-0946
DOI
10.1016/j.siny.2015.12.004
language
English
LU publication?
yes
id
13202ab3-2bda-46b3-9e16-ee0e61bb49fe (old id 8573682)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26810319?dopt=Abstract
date added to LUP
2016-02-16 11:16:34
date last changed
2017-10-29 03:21:01
@article{13202ab3-2bda-46b3-9e16-ee0e61bb49fe,
  abstract     = {Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is an alloimmune disorder resulting from platelet opsonization by maternal antibodies that destroy fetal platelets. The major risk of FNAIT is severe bleeding, particularly intracranial hemorrhage. Miscarriage has also been reported but the incidence requires further study. Analogous to adult autoimmune thrombocytopenia (ITP), the major target antigen in FNAIT is the platelet membrane glycoprotein (GP)IIbIIIa. FNAIT caused by antibodies against platelet GPIbα or other antigens has also been reported, but the reported incidence of the anti-GPIbα-mediated FNAIT is far lower than in ITP. To date, the maternal immune response to fetal platelet antigens is still not well understood and it is unclear why bleeding is more severe in FNAIT than in ITP. In this review, we introduce the pathogenesis of FNAIT, particularly those new discoveries from animal models, and discuss possible improvements for the diagnosis, therapy, and prevention of this devastating disease.},
  author       = {Zdravic, Darko and Yougbare, Issaka and Vadasz, Brian and Li, Conglei and Marshall, Alexandra H and Chen, Pingguo and Kjeldsen-Kragh, Jens and Ni, Heyu},
  issn         = {1878-0946},
  keyword      = {Antibody-induced immune suppression,Fetal and neonatal alloimmune thrombocytopenia,Intraveneous immunoglobulin G,Platelets},
  language     = {eng},
  number       = {1},
  pages        = {19--27},
  publisher    = {Elsevier},
  series       = {Seminars in Fetal & Neonatal Medicine},
  title        = {Fetal and neonatal alloimmune thrombocytopenia.},
  url          = {http://dx.doi.org/10.1016/j.siny.2015.12.004},
  volume       = {21},
  year         = {2016},
}