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Detecting Polygenic Evolution: Problems, Pitfalls, and Promises.

Wellenreuther, Maren LU and Hansson, Bengt LU (2016) In Trends in Genetics
Abstract
Unraveling the genetic basis of organismal form and function remains one of the major goals of evolutionary biology. Theory has long supported a model of polygenic evolution in which quantitative traits are underpinned by many genes of small effect, but empirical methods have lacked the power to detect causative loci when effect sizes are small or moderate. We (i) review traditional approaches used for identifying the molecular basis of phenotypic traits, to highlight the inherent problems and pitfalls that bias them towards the detection of large-effect loci. We then (ii) outline the promises of recent statistical frameworks to detect polygenic signatures of trait evolution, and discuss some of the first studies in evolutionary biology... (More)
Unraveling the genetic basis of organismal form and function remains one of the major goals of evolutionary biology. Theory has long supported a model of polygenic evolution in which quantitative traits are underpinned by many genes of small effect, but empirical methods have lacked the power to detect causative loci when effect sizes are small or moderate. We (i) review traditional approaches used for identifying the molecular basis of phenotypic traits, to highlight the inherent problems and pitfalls that bias them towards the detection of large-effect loci. We then (ii) outline the promises of recent statistical frameworks to detect polygenic signatures of trait evolution, and discuss some of the first studies in evolutionary biology employing these approaches. Lastly, we (iii) outline future directions and point to areas that still need development. (Less)
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author
organization
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Contribution to journal
publication status
published
subject
in
Trends in Genetics
publisher
Elsevier
external identifiers
  • pmid:26806794
  • scopus:84958748303
  • wos:000371843000003
ISSN
1362-4555
DOI
10.1016/j.tig.2015.12.004
language
English
LU publication?
yes
id
699ec2bb-afbc-4787-93fc-a1541ea09bfc (old id 8573830)
date added to LUP
2016-02-16 16:10:45
date last changed
2017-11-05 03:01:29
@article{699ec2bb-afbc-4787-93fc-a1541ea09bfc,
  abstract     = {Unraveling the genetic basis of organismal form and function remains one of the major goals of evolutionary biology. Theory has long supported a model of polygenic evolution in which quantitative traits are underpinned by many genes of small effect, but empirical methods have lacked the power to detect causative loci when effect sizes are small or moderate. We (i) review traditional approaches used for identifying the molecular basis of phenotypic traits, to highlight the inherent problems and pitfalls that bias them towards the detection of large-effect loci. We then (ii) outline the promises of recent statistical frameworks to detect polygenic signatures of trait evolution, and discuss some of the first studies in evolutionary biology employing these approaches. Lastly, we (iii) outline future directions and point to areas that still need development.},
  author       = {Wellenreuther, Maren and Hansson, Bengt},
  issn         = {1362-4555},
  language     = {eng},
  month        = {01},
  publisher    = {Elsevier},
  series       = {Trends in Genetics},
  title        = {Detecting Polygenic Evolution: Problems, Pitfalls, and Promises.},
  url          = {http://dx.doi.org/10.1016/j.tig.2015.12.004},
  year         = {2016},
}