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Prevalence of Contact Allergy to p-Phenylenediamine in the European General Population.

Diepgen, Thomas L; Naldi, Luigi; Bruze, Magnus LU ; Cazzaniga, Simone; Schuttelaar, Marie-Louise; Elsner, Peter; Goncalo, Margarida; Ofenloch, Robert and Svensson, Åke LU (2016) In Journal of Investigative Dermatology 136(2). p.409-415
Abstract
Population-based studies on contact allergy to p-phenylenediamine (PPD) are scarce. A cross-sectional study was performed to assess the prevalence of contact allergy to PPD and its risk factors in the general population of 5 European countries. A total of 10,425 subjects were interviewed, and a random sample (n = 2,739) was patch tested to PPD. Overall, 5,286 individuals (50.9%) reported having used hair colorants at least once in their lifetime (78% female, 20% male), and 35% had used hair colorants during the last 12 months. Hair colorant avoidance because of any skin problem during the lifetime was reported by 6%. Black henna tattoos had been used by 5.5% during their lifetime. The prevalence of PPD contact allergy was 0.8% (95%... (More)
Population-based studies on contact allergy to p-phenylenediamine (PPD) are scarce. A cross-sectional study was performed to assess the prevalence of contact allergy to PPD and its risk factors in the general population of 5 European countries. A total of 10,425 subjects were interviewed, and a random sample (n = 2,739) was patch tested to PPD. Overall, 5,286 individuals (50.9%) reported having used hair colorants at least once in their lifetime (78% female, 20% male), and 35% had used hair colorants during the last 12 months. Hair colorant avoidance because of any skin problem during the lifetime was reported by 6%. Black henna tattoos had been used by 5.5% during their lifetime. The prevalence of PPD contact allergy was 0.8% (95% confidence interval 0.6-1.0%), with no statistically significant association with gender or hair dye use. The prevalence of PPD in black henna tattoo users was 3.2% versus 0.6% in nonusers (P < 0.001). A clinically relevant positive patch test reaction to PPD related to hair coloring products was found in 0.1% (95% confidence interval 0.0-0.2%). A significant association with PPD contact allergy was observed for subjects who had black henna tattoos in their lifetime, with an age- and gender-adjusted odds ratio of 9.33 (95% confidence interval 3.45-25.26, P < 0.001). Black henna tattoos are an important risk factor for PPD contact allergy. (Less)
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type
Contribution to journal
publication status
published
subject
in
Journal of Investigative Dermatology
volume
136
issue
2
pages
409 - 415
publisher
Nature Publishing Group
external identifiers
  • pmid:26802237
  • wos:000369046000011
  • scopus:84973470890
ISSN
1523-1747
DOI
10.1016/j.jid.2015.10.064
language
English
LU publication?
yes
id
e7167149-028f-4a6b-9d3d-52ccfd549cd3 (old id 8573955)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26802237?dopt=Abstract
date added to LUP
2016-02-04 09:20:16
date last changed
2017-11-12 03:13:30
@article{e7167149-028f-4a6b-9d3d-52ccfd549cd3,
  abstract     = {Population-based studies on contact allergy to p-phenylenediamine (PPD) are scarce. A cross-sectional study was performed to assess the prevalence of contact allergy to PPD and its risk factors in the general population of 5 European countries. A total of 10,425 subjects were interviewed, and a random sample (n = 2,739) was patch tested to PPD. Overall, 5,286 individuals (50.9%) reported having used hair colorants at least once in their lifetime (78% female, 20% male), and 35% had used hair colorants during the last 12 months. Hair colorant avoidance because of any skin problem during the lifetime was reported by 6%. Black henna tattoos had been used by 5.5% during their lifetime. The prevalence of PPD contact allergy was 0.8% (95% confidence interval 0.6-1.0%), with no statistically significant association with gender or hair dye use. The prevalence of PPD in black henna tattoo users was 3.2% versus 0.6% in nonusers (P &lt; 0.001). A clinically relevant positive patch test reaction to PPD related to hair coloring products was found in 0.1% (95% confidence interval 0.0-0.2%). A significant association with PPD contact allergy was observed for subjects who had black henna tattoos in their lifetime, with an age- and gender-adjusted odds ratio of 9.33 (95% confidence interval 3.45-25.26, P &lt; 0.001). Black henna tattoos are an important risk factor for PPD contact allergy.},
  author       = {Diepgen, Thomas L and Naldi, Luigi and Bruze, Magnus and Cazzaniga, Simone and Schuttelaar, Marie-Louise and Elsner, Peter and Goncalo, Margarida and Ofenloch, Robert and Svensson, Åke},
  issn         = {1523-1747},
  language     = {eng},
  number       = {2},
  pages        = {409--415},
  publisher    = {Nature Publishing Group},
  series       = {Journal of Investigative Dermatology},
  title        = {Prevalence of Contact Allergy to p-Phenylenediamine in the European General Population.},
  url          = {http://dx.doi.org/10.1016/j.jid.2015.10.064},
  volume       = {136},
  year         = {2016},
}