Triolein from Coix lacryma-jobi induces cell cycle arrest through p53/p21 signaling pathway
(2016) In Biomedical and Pharmacology Journal 9(2). p.519-524- Abstract
p53, a tumor suppressor protein, has important roles in DNA repair, cell cycle and apoptosis, is a one of the key events in cancer development. Coix lacryma-jobi seed has been used as a food and traditional medicine plant with anti-oxidant, anti-cancer and anti-diabetic effects. In currently research, we identified the most potent p53-increasing compound among 4 compounds (1-4) found in Coix lacryma-jobi and demonstrated its molecular mechanism in MCF-7 cells. Among the four isolated compounds (1-4), triolein most increased p53. Triolein treatment induced p53, p21, p27 and Bax in MCF-7 cells. Moreover, triolein caused S phase arrest through suppression of CDK1, phopho-Rb and E2F1 in dose-dependent manner. We also observed the decreasing... (More)
p53, a tumor suppressor protein, has important roles in DNA repair, cell cycle and apoptosis, is a one of the key events in cancer development. Coix lacryma-jobi seed has been used as a food and traditional medicine plant with anti-oxidant, anti-cancer and anti-diabetic effects. In currently research, we identified the most potent p53-increasing compound among 4 compounds (1-4) found in Coix lacryma-jobi and demonstrated its molecular mechanism in MCF-7 cells. Among the four isolated compounds (1-4), triolein most increased p53. Triolein treatment induced p53, p21, p27 and Bax in MCF-7 cells. Moreover, triolein caused S phase arrest through suppression of CDK1, phopho-Rb and E2F1 in dose-dependent manner. We also observed the decreasing of DNA synthesis by triolein. These data suggest that triolein may induced cell cycle restart involve DNA synthesis and apoptosis pathway in MCF-7 cells.
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- author
- Hien Tran, Thi LU ; Ha, Do Thi; Truong, Do Minh; Duc, Loi Vu; Dao, Trong Tuan; Binh, Bui Thi and Hai, Nguyen Thanh
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Apoptosis, Coix lacryma-jobi, DNA synthesis, MCF-7 cells, Triolein
- in
- Biomedical and Pharmacology Journal
- volume
- 9
- issue
- 2
- pages
- 6 pages
- publisher
- Oriental Scientific Publishing Company
- external identifiers
-
- scopus:85009403504
- ISSN
- 0974-6242
- DOI
- 10.13005/bpj/967
- language
- English
- LU publication?
- yes
- id
- 8573a1d9-9672-4336-a183-50a05fb95e0e
- date added to LUP
- 2017-02-21 10:33:43
- date last changed
- 2019-02-20 10:25:03
@article{8573a1d9-9672-4336-a183-50a05fb95e0e,
abstract = {<p>p53, a tumor suppressor protein, has important roles in DNA repair, cell cycle and apoptosis, is a one of the key events in cancer development. Coix lacryma-jobi seed has been used as a food and traditional medicine plant with anti-oxidant, anti-cancer and anti-diabetic effects. In currently research, we identified the most potent p53-increasing compound among 4 compounds (1-4) found in Coix lacryma-jobi and demonstrated its molecular mechanism in MCF-7 cells. Among the four isolated compounds (1-4), triolein most increased p53. Triolein treatment induced p53, p21, p27 and Bax in MCF-7 cells. Moreover, triolein caused S phase arrest through suppression of CDK1, phopho-Rb and E2F1 in dose-dependent manner. We also observed the decreasing of DNA synthesis by triolein. These data suggest that triolein may induced cell cycle restart involve DNA synthesis and apoptosis pathway in MCF-7 cells.</p>},
author = {Hien Tran, Thi and Ha, Do Thi and Truong, Do Minh and Duc, Loi Vu and Dao, Trong Tuan and Binh, Bui Thi and Hai, Nguyen Thanh},
issn = {0974-6242},
keyword = {Apoptosis,Coix lacryma-jobi,DNA synthesis,MCF-7 cells,Triolein},
language = {eng},
number = {2},
pages = {519--524},
publisher = {Oriental Scientific Publishing Company},
series = {Biomedical and Pharmacology Journal},
title = {Triolein from Coix lacryma-jobi induces cell cycle arrest through p53/p21 signaling pathway},
url = {http://dx.doi.org/10.13005/bpj/967},
volume = {9},
year = {2016},
}