Triolein from Coix lacryma-jobi induces cell cycle arrest through p53/p21 signaling pathway
(2016) In Biomedical and Pharmacology Journal 9(2). p.519-524- Abstract
p53, a tumor suppressor protein, has important roles in DNA repair, cell cycle and apoptosis, is a one of the key events in cancer development. Coix lacryma-jobi seed has been used as a food and traditional medicine plant with anti-oxidant, anti-cancer and anti-diabetic effects. In currently research, we identified the most potent p53-increasing compound among 4 compounds (1-4) found in Coix lacryma-jobi and demonstrated its molecular mechanism in MCF-7 cells. Among the four isolated compounds (1-4), triolein most increased p53. Triolein treatment induced p53, p21, p27 and Bax in MCF-7 cells. Moreover, triolein caused S phase arrest through suppression of CDK1, phopho-Rb and E2F1 in dose-dependent manner. We also observed the decreasing... (More)
p53, a tumor suppressor protein, has important roles in DNA repair, cell cycle and apoptosis, is a one of the key events in cancer development. Coix lacryma-jobi seed has been used as a food and traditional medicine plant with anti-oxidant, anti-cancer and anti-diabetic effects. In currently research, we identified the most potent p53-increasing compound among 4 compounds (1-4) found in Coix lacryma-jobi and demonstrated its molecular mechanism in MCF-7 cells. Among the four isolated compounds (1-4), triolein most increased p53. Triolein treatment induced p53, p21, p27 and Bax in MCF-7 cells. Moreover, triolein caused S phase arrest through suppression of CDK1, phopho-Rb and E2F1 in dose-dependent manner. We also observed the decreasing of DNA synthesis by triolein. These data suggest that triolein may induced cell cycle restart involve DNA synthesis and apoptosis pathway in MCF-7 cells.
(Less)
- author
- Hien Tran, Thi LU ; Ha, Do Thi ; Truong, Do Minh ; Duc, Loi Vu ; Dao, Trong Tuan ; Binh, Bui Thi and Hai, Nguyen Thanh
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Apoptosis, Coix lacryma-jobi, DNA synthesis, MCF-7 cells, Triolein
- in
- Biomedical and Pharmacology Journal
- volume
- 9
- issue
- 2
- pages
- 6 pages
- publisher
- Oriental Scientific Publishing Company
- external identifiers
-
- scopus:85009403504
- ISSN
- 0974-6242
- DOI
- 10.13005/bpj/967
- language
- English
- LU publication?
- yes
- id
- 8573a1d9-9672-4336-a183-50a05fb95e0e
- date added to LUP
- 2017-02-21 10:33:43
- date last changed
- 2022-01-30 18:15:11
@article{8573a1d9-9672-4336-a183-50a05fb95e0e, abstract = {{<p>p53, a tumor suppressor protein, has important roles in DNA repair, cell cycle and apoptosis, is a one of the key events in cancer development. Coix lacryma-jobi seed has been used as a food and traditional medicine plant with anti-oxidant, anti-cancer and anti-diabetic effects. In currently research, we identified the most potent p53-increasing compound among 4 compounds (1-4) found in Coix lacryma-jobi and demonstrated its molecular mechanism in MCF-7 cells. Among the four isolated compounds (1-4), triolein most increased p53. Triolein treatment induced p53, p21, p27 and Bax in MCF-7 cells. Moreover, triolein caused S phase arrest through suppression of CDK1, phopho-Rb and E2F1 in dose-dependent manner. We also observed the decreasing of DNA synthesis by triolein. These data suggest that triolein may induced cell cycle restart involve DNA synthesis and apoptosis pathway in MCF-7 cells.</p>}}, author = {{Hien Tran, Thi and Ha, Do Thi and Truong, Do Minh and Duc, Loi Vu and Dao, Trong Tuan and Binh, Bui Thi and Hai, Nguyen Thanh}}, issn = {{0974-6242}}, keywords = {{Apoptosis; Coix lacryma-jobi; DNA synthesis; MCF-7 cells; Triolein}}, language = {{eng}}, number = {{2}}, pages = {{519--524}}, publisher = {{Oriental Scientific Publishing Company}}, series = {{Biomedical and Pharmacology Journal}}, title = {{Triolein from Coix lacryma-jobi induces cell cycle arrest through p53/p21 signaling pathway}}, url = {{http://dx.doi.org/10.13005/bpj/967}}, doi = {{10.13005/bpj/967}}, volume = {{9}}, year = {{2016}}, }