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Triolein from Coix lacryma-jobi induces cell cycle arrest through p53/p21 signaling pathway

Hien Tran, Thi LU ; Ha, Do Thi ; Truong, Do Minh ; Duc, Loi Vu ; Dao, Trong Tuan ; Binh, Bui Thi and Hai, Nguyen Thanh (2016) In Biomedical and Pharmacology Journal 9(2). p.519-524
Abstract

p53, a tumor suppressor protein, has important roles in DNA repair, cell cycle and apoptosis, is a one of the key events in cancer development. Coix lacryma-jobi seed has been used as a food and traditional medicine plant with anti-oxidant, anti-cancer and anti-diabetic effects. In currently research, we identified the most potent p53-increasing compound among 4 compounds (1-4) found in Coix lacryma-jobi and demonstrated its molecular mechanism in MCF-7 cells. Among the four isolated compounds (1-4), triolein most increased p53. Triolein treatment induced p53, p21, p27 and Bax in MCF-7 cells. Moreover, triolein caused S phase arrest through suppression of CDK1, phopho-Rb and E2F1 in dose-dependent manner. We also observed the decreasing... (More)

p53, a tumor suppressor protein, has important roles in DNA repair, cell cycle and apoptosis, is a one of the key events in cancer development. Coix lacryma-jobi seed has been used as a food and traditional medicine plant with anti-oxidant, anti-cancer and anti-diabetic effects. In currently research, we identified the most potent p53-increasing compound among 4 compounds (1-4) found in Coix lacryma-jobi and demonstrated its molecular mechanism in MCF-7 cells. Among the four isolated compounds (1-4), triolein most increased p53. Triolein treatment induced p53, p21, p27 and Bax in MCF-7 cells. Moreover, triolein caused S phase arrest through suppression of CDK1, phopho-Rb and E2F1 in dose-dependent manner. We also observed the decreasing of DNA synthesis by triolein. These data suggest that triolein may induced cell cycle restart involve DNA synthesis and apoptosis pathway in MCF-7 cells.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Apoptosis, Coix lacryma-jobi, DNA synthesis, MCF-7 cells, Triolein
in
Biomedical and Pharmacology Journal
volume
9
issue
2
pages
6 pages
publisher
Oriental Scientific Publishing Company
external identifiers
  • scopus:85009403504
ISSN
0974-6242
DOI
10.13005/bpj/967
language
English
LU publication?
yes
id
8573a1d9-9672-4336-a183-50a05fb95e0e
date added to LUP
2017-02-21 10:33:43
date last changed
2025-04-04 14:54:13
@article{8573a1d9-9672-4336-a183-50a05fb95e0e,
  abstract     = {{<p>p53, a tumor suppressor protein, has important roles in DNA repair, cell cycle and apoptosis, is a one of the key events in cancer development. Coix lacryma-jobi seed has been used as a food and traditional medicine plant with anti-oxidant, anti-cancer and anti-diabetic effects. In currently research, we identified the most potent p53-increasing compound among 4 compounds (1-4) found in Coix lacryma-jobi and demonstrated its molecular mechanism in MCF-7 cells. Among the four isolated compounds (1-4), triolein most increased p53. Triolein treatment induced p53, p21, p27 and Bax in MCF-7 cells. Moreover, triolein caused S phase arrest through suppression of CDK1, phopho-Rb and E2F1 in dose-dependent manner. We also observed the decreasing of DNA synthesis by triolein. These data suggest that triolein may induced cell cycle restart involve DNA synthesis and apoptosis pathway in MCF-7 cells.</p>}},
  author       = {{Hien Tran, Thi and Ha, Do Thi and Truong, Do Minh and Duc, Loi Vu and Dao, Trong Tuan and Binh, Bui Thi and Hai, Nguyen Thanh}},
  issn         = {{0974-6242}},
  keywords     = {{Apoptosis; Coix lacryma-jobi; DNA synthesis; MCF-7 cells; Triolein}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{519--524}},
  publisher    = {{Oriental Scientific Publishing Company}},
  series       = {{Biomedical and Pharmacology Journal}},
  title        = {{Triolein from Coix lacryma-jobi induces cell cycle arrest through p53/p21 signaling pathway}},
  url          = {{http://dx.doi.org/10.13005/bpj/967}},
  doi          = {{10.13005/bpj/967}},
  volume       = {{9}},
  year         = {{2016}},
}