The CD44 ligand hyaluronic acid is elevated in the cerebrospinal fluid of suicide attempters and is associated with increased blood-brain barrier permeability.
(2016) In Journal of Affective Disorders 193. p.349-354- Abstract
- The glycosaminoglycan hyaluronic acid (HA) is an important component of the extracellular matrix (ECM) in the brain. CD44 is a cell adhesion molecule that binds to HA in the ECM and is present on astrocytes, microglia and certain neurons. Cell adhesion molecules have been reported to be involved in anxiety and mood disorders. CD44 levels are decreased in the cerebrospinal fluid (CSF) of depressed individuals, and the CD44 gene has been identified in brain GWAS studies as a possible risk gene for suicidal behavior.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8576654
- author
- Ventorp, Filip LU ; Bay-Richter, Cecilie LU ; Sauro, Analise ; Janelidze, Shorena LU ; Matsson, Viktor Sjödahl ; Lipton, Jack ; Nordström, Ulrika LU ; Westrin, Åsa LU ; Brundin, Patrik LU and Brundin, Lena LU
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Affective Disorders
- volume
- 193
- pages
- 349 - 354
- publisher
- Elsevier
- external identifiers
-
- pmid:26796235
- wos:000369586000049
- scopus:84962601364
- pmid:26796235
- ISSN
- 1573-2517
- DOI
- 10.1016/j.jad.2015.12.069
- project
- Individanpassad behandling av patienter med depression, med särskilt fokus på suicidrisk.
- language
- English
- LU publication?
- yes
- id
- 765cbf7d-ff71-4548-8c9a-3bfb48d22b30 (old id 8576654)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26796235?dopt=Abstract
- date added to LUP
- 2016-04-04 07:49:09
- date last changed
- 2022-04-23 08:39:55
@article{765cbf7d-ff71-4548-8c9a-3bfb48d22b30, abstract = {{The glycosaminoglycan hyaluronic acid (HA) is an important component of the extracellular matrix (ECM) in the brain. CD44 is a cell adhesion molecule that binds to HA in the ECM and is present on astrocytes, microglia and certain neurons. Cell adhesion molecules have been reported to be involved in anxiety and mood disorders. CD44 levels are decreased in the cerebrospinal fluid (CSF) of depressed individuals, and the CD44 gene has been identified in brain GWAS studies as a possible risk gene for suicidal behavior.}}, author = {{Ventorp, Filip and Bay-Richter, Cecilie and Sauro, Analise and Janelidze, Shorena and Matsson, Viktor Sjödahl and Lipton, Jack and Nordström, Ulrika and Westrin, Åsa and Brundin, Patrik and Brundin, Lena}}, issn = {{1573-2517}}, language = {{eng}}, pages = {{349--354}}, publisher = {{Elsevier}}, series = {{Journal of Affective Disorders}}, title = {{The CD44 ligand hyaluronic acid is elevated in the cerebrospinal fluid of suicide attempters and is associated with increased blood-brain barrier permeability.}}, url = {{http://dx.doi.org/10.1016/j.jad.2015.12.069}}, doi = {{10.1016/j.jad.2015.12.069}}, volume = {{193}}, year = {{2016}}, }