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The CD44 ligand hyaluronic acid is elevated in the cerebrospinal fluid of suicide attempters and is associated with increased blood-brain barrier permeability.

Ventorp, Filip LU ; Bay-Richter, Cecilie LU ; Sauro, Analise; Janelidze, Shorena LU ; Matsson, Viktor Sjödahl; Lipton, Jack; Nordström, Ulrika LU ; Westrin, Åsa LU ; Brundin, Patrik LU and Brundin, Lena LU (2016) In Journal of Affective Disorders 193. p.349-354
Abstract
The glycosaminoglycan hyaluronic acid (HA) is an important component of the extracellular matrix (ECM) in the brain. CD44 is a cell adhesion molecule that binds to HA in the ECM and is present on astrocytes, microglia and certain neurons. Cell adhesion molecules have been reported to be involved in anxiety and mood disorders. CD44 levels are decreased in the cerebrospinal fluid (CSF) of depressed individuals, and the CD44 gene has been identified in brain GWAS studies as a possible risk gene for suicidal behavior.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Affective Disorders
volume
193
pages
349 - 354
publisher
Elsevier
external identifiers
  • pmid:26796235
  • wos:000369586000049
  • scopus:84962601364
ISSN
1573-2517
DOI
10.1016/j.jad.2015.12.069
language
English
LU publication?
yes
id
765cbf7d-ff71-4548-8c9a-3bfb48d22b30 (old id 8576654)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26796235?dopt=Abstract
date added to LUP
2016-02-03 21:40:44
date last changed
2017-04-30 15:29:48
@article{765cbf7d-ff71-4548-8c9a-3bfb48d22b30,
  abstract     = {The glycosaminoglycan hyaluronic acid (HA) is an important component of the extracellular matrix (ECM) in the brain. CD44 is a cell adhesion molecule that binds to HA in the ECM and is present on astrocytes, microglia and certain neurons. Cell adhesion molecules have been reported to be involved in anxiety and mood disorders. CD44 levels are decreased in the cerebrospinal fluid (CSF) of depressed individuals, and the CD44 gene has been identified in brain GWAS studies as a possible risk gene for suicidal behavior.},
  author       = {Ventorp, Filip and Bay-Richter, Cecilie and Sauro, Analise and Janelidze, Shorena and Matsson, Viktor Sjödahl and Lipton, Jack and Nordström, Ulrika and Westrin, Åsa and Brundin, Patrik and Brundin, Lena},
  issn         = {1573-2517},
  language     = {eng},
  pages        = {349--354},
  publisher    = {Elsevier},
  series       = {Journal of Affective Disorders},
  title        = {The CD44 ligand hyaluronic acid is elevated in the cerebrospinal fluid of suicide attempters and is associated with increased blood-brain barrier permeability.},
  url          = {http://dx.doi.org/10.1016/j.jad.2015.12.069},
  volume       = {193},
  year         = {2016},
}