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Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference.

Wen, Wanqing; Kato, Norihiro; Hwang, Joo-Yeon; Guo, Xingyi; Tabara, Yasuharu; Li, Huaixing; Dorajoo, Rajkumar; Yang, Xiaobo; Tsai, Fuu-Jen and Li, Shengxu, et al. (2016) In Scientific Reports 6.
Abstract
Sixty genetic loci associated with abdominal obesity, measured by waist circumference (WC) and waist-hip ratio (WHR), have been previously identified, primarily from studies conducted in European-ancestry populations. We conducted a meta-analysis of associations of abdominal obesity with approximately 2.5 million single nucleotide polymorphisms (SNPs) among 53,052 (for WC) and 48,312 (for WHR) individuals of Asian descent, and replicated 33 selected SNPs among 3,762 to 17,110 additional individuals. We identified four novel loci near the EFEMP1, ADAMTSL3 , CNPY2, and GNAS genes that were associated with WC after adjustment for body mass index (BMI); two loci near the NID2 and HLA-DRB5 genes associated with WHR after adjustment for BMI, and... (More)
Sixty genetic loci associated with abdominal obesity, measured by waist circumference (WC) and waist-hip ratio (WHR), have been previously identified, primarily from studies conducted in European-ancestry populations. We conducted a meta-analysis of associations of abdominal obesity with approximately 2.5 million single nucleotide polymorphisms (SNPs) among 53,052 (for WC) and 48,312 (for WHR) individuals of Asian descent, and replicated 33 selected SNPs among 3,762 to 17,110 additional individuals. We identified four novel loci near the EFEMP1, ADAMTSL3 , CNPY2, and GNAS genes that were associated with WC after adjustment for body mass index (BMI); two loci near the NID2 and HLA-DRB5 genes associated with WHR after adjustment for BMI, and three loci near the CEP120, TSC22D2, and SLC22A2 genes associated with WC without adjustment for BMI. Functional enrichment analyses revealed enrichment of corticotropin-releasing hormone signaling, GNRH signaling, and/or CDK5 signaling pathways for those newly-identified loci. Our study provides additional insight on genetic contribution to abdominal obesity. (Less)
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Scientific Reports
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6
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Nature Publishing Group
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  • pmid:26785701
  • wos:000368348500001
  • scopus:84955278775
ISSN
2045-2322
DOI
10.1038/srep17958
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English
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d80dfcea-5347-488c-8734-d115e2804d06 (old id 8576896)
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@article{d80dfcea-5347-488c-8734-d115e2804d06,
  abstract     = {Sixty genetic loci associated with abdominal obesity, measured by waist circumference (WC) and waist-hip ratio (WHR), have been previously identified, primarily from studies conducted in European-ancestry populations. We conducted a meta-analysis of associations of abdominal obesity with approximately 2.5 million single nucleotide polymorphisms (SNPs) among 53,052 (for WC) and 48,312 (for WHR) individuals of Asian descent, and replicated 33 selected SNPs among 3,762 to 17,110 additional individuals. We identified four novel loci near the EFEMP1, ADAMTSL3 , CNPY2, and GNAS genes that were associated with WC after adjustment for body mass index (BMI); two loci near the NID2 and HLA-DRB5 genes associated with WHR after adjustment for BMI, and three loci near the CEP120, TSC22D2, and SLC22A2 genes associated with WC without adjustment for BMI. Functional enrichment analyses revealed enrichment of corticotropin-releasing hormone signaling, GNRH signaling, and/or CDK5 signaling pathways for those newly-identified loci. Our study provides additional insight on genetic contribution to abdominal obesity.},
  articleno    = {17958},
  author       = {Wen, Wanqing and Kato, Norihiro and Hwang, Joo-Yeon and Guo, Xingyi and Tabara, Yasuharu and Li, Huaixing and Dorajoo, Rajkumar and Yang, Xiaobo and Tsai, Fuu-Jen and Li, Shengxu and Wu, Ying and Wu, Tangchun and Kim, Soriul and Guo, Xiuqing and Liang, Jun and Shungin, Dmitry and Adair, Linda S and Akiyama, Koichi and Allison, Matthew and Cai, Qiuyin and Chang, Li-Ching and Chen, Chien-Hsiun and Chen, Yuan-Tsong and Cho, Yoon Shin and Choi, Bo Youl and Gao, Yutang and Go, Min Jin and Gu, Dongfeng and Han, Bok-Ghee and He, Meian and Hixson, James E and Hu, Yanling and Huang, Tao and Isono, Masato and Jung, Keum Ji and Kang, Daehee and Kim, Young Jin and Kita, Yoshikuni and Lee, Juyoung and Lee, Nanette R and Lee, Jeannette and Wang, Yiqin and Liu, Jian-Jun and Long, Jirong and Moon, Sanghoon and Nakamura, Yasuyuki and Nakatochi, Masahiro and Ohnaka, Keizo and Rao, Dabeeru and Shi, Jiajun and Sull, Jae Woong and Tan, Aihua and Ueshima, Hirotsugu and Wu, Chen and Xiang, Yong-Bing and Yamamoto, Ken and Yao, Jie and Ye, Xingwang and Yokota, Mitsuhiro and Zhang, Xiaomin and Zheng, Yan and Qi, Lu and Rotter, Jerome I and Jee, Sun Ha and Lin, Dongxin and Mohlke, Karen L and He, Jiang and Mo, Zengnan and Wu, Jer-Yuarn and Tai, E Shyong and Lin, Xu and Miki, Tetsuro and Kim, Bong-Jo and Takeuchi, Fumihiko and Zheng, Wei and Shu, Xiao-Ou},
  issn         = {2045-2322},
  language     = {eng},
  publisher    = {Nature Publishing Group},
  series       = {Scientific Reports},
  title        = {Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference.},
  url          = {http://dx.doi.org/10.1038/srep17958},
  volume       = {6},
  year         = {2016},
}