IgA- and SIgA anti-PR3 antibodies in serum versus organ involvement and disease activity in PR3-ANCA-associated vasculitis
Sandin, C. LU ; Eriksson, P. ; Segelmark, M. LU
; Skogh, T.
and Kastbom, A.
(2016)
In Clinical and Experimental Immunology
184(2).
p.208-215
- Abstract
Circulating immunoglobulin (Ig)A class anti-neutrophil cytoplasm antibodies (ANCA) directed against proteinase 3 (PR3) have been reported in ANCA-associated vasculitis (AAV) with mucosal involvement. However, secretory IgA (SIgA) PR3-ANCA has not been reported previously. In this study we compared serum levels of SIgA PR3-ANCA and IgA PR3-ANCA with IgG PR3-ANCA in relation to disease characteristics. Among 73 patients with AAV and PR3-ANCA at diagnosis, 84% tested positive for IgG PR3-ANCA, 47% for IgA-ANCA and 36% for SIgA PR3-ANCA at the time of sampling for the present study. IgA and IgG PR3-ANCA were represented similarly among patients with different organ manifestations, i.e. upper airway, lung or kidney at time of sampling.... (More)
Circulating immunoglobulin (Ig)A class anti-neutrophil cytoplasm antibodies (ANCA) directed against proteinase 3 (PR3) have been reported in ANCA-associated vasculitis (AAV) with mucosal involvement. However, secretory IgA (SIgA) PR3-ANCA has not been reported previously. In this study we compared serum levels of SIgA PR3-ANCA and IgA PR3-ANCA with IgG PR3-ANCA in relation to disease characteristics. Among 73 patients with AAV and PR3-ANCA at diagnosis, 84% tested positive for IgG PR3-ANCA, 47% for IgA-ANCA and 36% for SIgA PR3-ANCA at the time of sampling for the present study. IgA and IgG PR3-ANCA were represented similarly among patients with different organ manifestations, i.e. upper airway, lung or kidney at time of sampling. However, SIgA PR3-ANCA was significantly less represented among patients with upper airway involvement. During active disease, the proportions of IgA PR3-ANCA and SIgA PR3-ANCA-positive patients were significantly higher compared to inactive disease. Eight patients were sampled prospectively during 24 months from onset of active disease. In these patients, IgA PR3-ANCA and SIgA PR3-ANCA turned negative more often after remission induction compared to IgG PR3-ANCA. Our findings suggest that serum IgA PR3-ANCA and SIgA PR3-ANCA are related more closely to disease activity in AAV compared to IgG PR3-ANCA. Further studies are required to reveal if this has implications for disease activity monitoring. The mean number of PR3-ANCA isotypes increased along with disease activity, suggesting a global B cell activation during active disease.
(Less)
- author
- Sandin, C.
LU
; Eriksson, P.
; Segelmark, M.
LU
; Skogh, T.
and Kastbom, A.
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- ANCA-associated vasculitis, disease, IgA PR3-ANCA, mucosal immunity activity
- in
- Clinical and Experimental Immunology
- volume
- 184
- issue
- 2
- pages
- 208 - 215
- publisher
- Oxford University Press
- external identifiers
-
- pmid:26762653
- scopus:84983315974
- ISSN
- 0009-9104
- DOI
- 10.1111/cei.12769
- language
- English
- LU publication?
- no
- id
- 857c36b8-7c3c-477a-ae7f-c2bb6b166eca
- date added to LUP
- 2020-06-15 16:56:04
- date last changed
- 2025-10-14 10:36:45
@article{857c36b8-7c3c-477a-ae7f-c2bb6b166eca,
abstract = {{<p>Circulating immunoglobulin (Ig)A class anti-neutrophil cytoplasm antibodies (ANCA) directed against proteinase 3 (PR3) have been reported in ANCA-associated vasculitis (AAV) with mucosal involvement. However, secretory IgA (SIgA) PR3-ANCA has not been reported previously. In this study we compared serum levels of SIgA PR3-ANCA and IgA PR3-ANCA with IgG PR3-ANCA in relation to disease characteristics. Among 73 patients with AAV and PR3-ANCA at diagnosis, 84% tested positive for IgG PR3-ANCA, 47% for IgA-ANCA and 36% for SIgA PR3-ANCA at the time of sampling for the present study. IgA and IgG PR3-ANCA were represented similarly among patients with different organ manifestations, i.e. upper airway, lung or kidney at time of sampling. However, SIgA PR3-ANCA was significantly less represented among patients with upper airway involvement. During active disease, the proportions of IgA PR3-ANCA and SIgA PR3-ANCA-positive patients were significantly higher compared to inactive disease. Eight patients were sampled prospectively during 24 months from onset of active disease. In these patients, IgA PR3-ANCA and SIgA PR3-ANCA turned negative more often after remission induction compared to IgG PR3-ANCA. Our findings suggest that serum IgA PR3-ANCA and SIgA PR3-ANCA are related more closely to disease activity in AAV compared to IgG PR3-ANCA. Further studies are required to reveal if this has implications for disease activity monitoring. The mean number of PR3-ANCA isotypes increased along with disease activity, suggesting a global B cell activation during active disease.</p>}},
author = {{Sandin, C. and Eriksson, P. and Segelmark, M. and Skogh, T. and Kastbom, A.}},
issn = {{0009-9104}},
keywords = {{ANCA-associated vasculitis; disease; IgA PR3-ANCA; mucosal immunity activity}},
language = {{eng}},
number = {{2}},
pages = {{208--215}},
publisher = {{Oxford University Press}},
series = {{Clinical and Experimental Immunology}},
title = {{IgA- and SIgA anti-PR3 antibodies in serum versus organ involvement and disease activity in PR3-ANCA-associated vasculitis}},
url = {{http://dx.doi.org/10.1111/cei.12769}},
doi = {{10.1111/cei.12769}},
volume = {{184}},
year = {{2016}},
}