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Peripheral serotonin levels as a predictor of antidepressant treatment response : A systematic review

Holck, Amanda LU ; Movahed, Pouya LU ; Westrin, Åsa LU ; Wolkowitz, Owen M. LU ; Lindqvist, Daniel LU and Asp, Marie LU (2024) In Progress in Neuro-Psychopharmacology and Biological Psychiatry 133.
Abstract

There are currently no reliable biomarkers to predict clinical response to pharmacological treatments of depressive disorders. Peripheral blood 5-hydroxytryptamine (5-HT; serotonin) has been suggested as a biomarker of antidepressant treatment response, but there has not been an attempt to systematically summarize and evaluate the scientific evidence of this hypothesis. In this systematic review we searched MEDLINE, Embase, PsycINFO, and the Cochrane Central Register of Controlled Trials. Twenty-six relevant studies investigating peripheral 5-HT as an antidepressant biomarker were identified. In all, we did not find robust support for an association between baseline 5-HT and treatment response. Several larger studies with lower risk of... (More)

There are currently no reliable biomarkers to predict clinical response to pharmacological treatments of depressive disorders. Peripheral blood 5-hydroxytryptamine (5-HT; serotonin) has been suggested as a biomarker of antidepressant treatment response, but there has not been an attempt to systematically summarize and evaluate the scientific evidence of this hypothesis. In this systematic review we searched MEDLINE, Embase, PsycINFO, and the Cochrane Central Register of Controlled Trials. Twenty-six relevant studies investigating peripheral 5-HT as an antidepressant biomarker were identified. In all, we did not find robust support for an association between baseline 5-HT and treatment response. Several larger studies with lower risk of bias, however, showed that higher baseline 5-HT was associated with a greater antidepressant response to SSRIs, prompting future studies to investigate this hypothesis. Our results also confirm previous reports that SSRI treatment is associated with a decrease in peripheral 5-HT levels; however, we were not able to confirm that larger decreases of 5-HT are associated with better treatment outcome as results were inconclusive.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
5-hydroxytryptamine, Antidepressant treatment, Biomarkers, Depressive disorders, SSRIs
in
Progress in Neuro-Psychopharmacology and Biological Psychiatry
volume
133
article number
111031
publisher
Elsevier
external identifiers
  • scopus:85193639162
  • pmid:38762162
ISSN
0278-5846
DOI
10.1016/j.pnpbp.2024.111031
language
English
LU publication?
yes
id
857e82b4-9f70-4527-8979-08ffb1c18faf
date added to LUP
2024-06-05 13:26:09
date last changed
2024-06-19 14:15:39
@article{857e82b4-9f70-4527-8979-08ffb1c18faf,
  abstract     = {{<p>There are currently no reliable biomarkers to predict clinical response to pharmacological treatments of depressive disorders. Peripheral blood 5-hydroxytryptamine (5-HT; serotonin) has been suggested as a biomarker of antidepressant treatment response, but there has not been an attempt to systematically summarize and evaluate the scientific evidence of this hypothesis. In this systematic review we searched MEDLINE, Embase, PsycINFO, and the Cochrane Central Register of Controlled Trials. Twenty-six relevant studies investigating peripheral 5-HT as an antidepressant biomarker were identified. In all, we did not find robust support for an association between baseline 5-HT and treatment response. Several larger studies with lower risk of bias, however, showed that higher baseline 5-HT was associated with a greater antidepressant response to SSRIs, prompting future studies to investigate this hypothesis. Our results also confirm previous reports that SSRI treatment is associated with a decrease in peripheral 5-HT levels; however, we were not able to confirm that larger decreases of 5-HT are associated with better treatment outcome as results were inconclusive.</p>}},
  author       = {{Holck, Amanda and Movahed, Pouya and Westrin, Åsa and Wolkowitz, Owen M. and Lindqvist, Daniel and Asp, Marie}},
  issn         = {{0278-5846}},
  keywords     = {{5-hydroxytryptamine; Antidepressant treatment; Biomarkers; Depressive disorders; SSRIs}},
  language     = {{eng}},
  month        = {{07}},
  publisher    = {{Elsevier}},
  series       = {{Progress in Neuro-Psychopharmacology and Biological Psychiatry}},
  title        = {{Peripheral serotonin levels as a predictor of antidepressant treatment response : A systematic review}},
  url          = {{http://dx.doi.org/10.1016/j.pnpbp.2024.111031}},
  doi          = {{10.1016/j.pnpbp.2024.111031}},
  volume       = {{133}},
  year         = {{2024}},
}