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Sentinel lymph node biopsy staging for cutaneous malignant melanoma of the head and neck.

Hafström, Anna LU ; Romell, Anton ; Ingvar, Christian LU ; Wahlberg, Peter LU and Greiff, Lennart LU (2016) In Acta Oto-Laryngologica 136(3).
Abstract
Conclusion Sentinel lymph node biopsies (SLNBs) can be performed safely and with reasonable accuracy in HNM patients. The outcome provides important prognostic information concerning DFS and further treatment. However, one must recognize that SLNB is a multidisciplinary procedure with a learning curve for all. Objectives To evaluate efficacy of performing SLNBs in a series of consecutive patients with cutaneous head and neck melanoma (HNM) ≥ T1b from introduction of the procedure and 10 years onward. Method End-points comprised of SLNB outcome, disease-free survival (DFS), and overall survival (OS). Results SNs were harvested in 128 of 160 patients (median Breslow = 2.0 mm, 29% ulcerated); success rate = 80.0%, or 92.1% if excluding... (More)
Conclusion Sentinel lymph node biopsies (SLNBs) can be performed safely and with reasonable accuracy in HNM patients. The outcome provides important prognostic information concerning DFS and further treatment. However, one must recognize that SLNB is a multidisciplinary procedure with a learning curve for all. Objectives To evaluate efficacy of performing SLNBs in a series of consecutive patients with cutaneous head and neck melanoma (HNM) ≥ T1b from introduction of the procedure and 10 years onward. Method End-points comprised of SLNB outcome, disease-free survival (DFS), and overall survival (OS). Results SNs were harvested in 128 of 160 patients (median Breslow = 2.0 mm, 29% ulcerated); success rate = 80.0%, or 92.1% if excluding patients where SLNBs were omitted due to non-localization on pre-operative imaging or because of SN-location in the parotid basin. Ten patients (7.8%) had positive SLNBs and were offered early completion neck dissections. Of the 146 patients available for follow-up (median = 27 months), 15.8% had recurrent disease. The risk of a regional nodal recurrence after a negative SLNB was 7.5%. SN-negative patients had improved DFS c.f. SN-positive patients (p < 0.001). A positive SLNB was the most important prognostic predictor of decreased DFS (hazard ratio = 5.70; p < 0.005), but had no significant impact on OS. (Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oto-Laryngologica
volume
136
issue
3
publisher
Taylor & Francis
external identifiers
  • pmid:26767628
  • scopus:84956963703
  • pmid:26767628
  • wos:000375933300018
ISSN
1651-2251
DOI
10.3109/00016489.2015.1113559
project
Riskfaktorer, prognos och överlevnad för patienter med maligna melanom i huvud- och halsområdet
language
English
LU publication?
yes
id
2126de14-35b4-4b5e-b911-99a884772463 (old id 8589134)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26767628?dopt=Abstract
date added to LUP
2016-04-04 09:36:20
date last changed
2025-04-04 15:10:44
@article{2126de14-35b4-4b5e-b911-99a884772463,
  abstract     = {{Conclusion Sentinel lymph node biopsies (SLNBs) can be performed safely and with reasonable accuracy in HNM patients. The outcome provides important prognostic information concerning DFS and further treatment. However, one must recognize that SLNB is a multidisciplinary procedure with a learning curve for all. Objectives To evaluate efficacy of performing SLNBs in a series of consecutive patients with cutaneous head and neck melanoma (HNM) ≥ T1b from introduction of the procedure and 10 years onward. Method End-points comprised of SLNB outcome, disease-free survival (DFS), and overall survival (OS). Results SNs were harvested in 128 of 160 patients (median Breslow = 2.0 mm, 29% ulcerated); success rate = 80.0%, or 92.1% if excluding patients where SLNBs were omitted due to non-localization on pre-operative imaging or because of SN-location in the parotid basin. Ten patients (7.8%) had positive SLNBs and were offered early completion neck dissections. Of the 146 patients available for follow-up (median = 27 months), 15.8% had recurrent disease. The risk of a regional nodal recurrence after a negative SLNB was 7.5%. SN-negative patients had improved DFS c.f. SN-positive patients (p &lt; 0.001). A positive SLNB was the most important prognostic predictor of decreased DFS (hazard ratio = 5.70; p &lt; 0.005), but had no significant impact on OS.}},
  author       = {{Hafström, Anna and Romell, Anton and Ingvar, Christian and Wahlberg, Peter and Greiff, Lennart}},
  issn         = {{1651-2251}},
  language     = {{eng}},
  number       = {{3}},
  publisher    = {{Taylor & Francis}},
  series       = {{Acta Oto-Laryngologica}},
  title        = {{Sentinel lymph node biopsy staging for cutaneous malignant melanoma of the head and neck.}},
  url          = {{http://dx.doi.org/10.3109/00016489.2015.1113559}},
  doi          = {{10.3109/00016489.2015.1113559}},
  volume       = {{136}},
  year         = {{2016}},
}