Cardiovascular risk with androgen deprivation therapy for prostate cancer: Potential mechanisms.
(2015) In Urologic Oncology 33(11). p.464-475- Abstract
- Androgen deprivation therapy (ADT) is frequently used for the treatment of advanced prostate cancer. ADT is associated with numerous side effects related to its mode of action, namely the suppression of testosterone to castrate levels. Recently, several large retrospective studies have also reported an increased risk of diabetes and cardiovascular disease in men receiving ADT, although these risks have not been confirmed by prospective randomized trials. We review the literature to consider the risk of cardiovascular disease with different forms of ADT and examine in detail potential mechanisms by which any such risk could be mediated. Mechanisms discussed include the metabolic syndrome resulting from low testosterone level and the... (More)
- Androgen deprivation therapy (ADT) is frequently used for the treatment of advanced prostate cancer. ADT is associated with numerous side effects related to its mode of action, namely the suppression of testosterone to castrate levels. Recently, several large retrospective studies have also reported an increased risk of diabetes and cardiovascular disease in men receiving ADT, although these risks have not been confirmed by prospective randomized trials. We review the literature to consider the risk of cardiovascular disease with different forms of ADT and examine in detail potential mechanisms by which any such risk could be mediated. Mechanisms discussed include the metabolic syndrome resulting from low testosterone level and the potential roles of testosterone flare, gonadotropin-releasing hormone receptors outside the pituitary gland, and altered levels of follicle-stimulating hormone. Finally, the clinical implications for men prescribed ADT for the treatment of advanced prostate cancer are considered. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7750767
- author
- Tivesten, Åsa ; Pinthus, Jehonathan H ; Clarke, Noel ; Duivenvoorden, Wilhelmina and Nilsson, Jan LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Urologic Oncology
- volume
- 33
- issue
- 11
- pages
- 464 - 475
- publisher
- Elsevier
- external identifiers
-
- pmid:26141678
- wos:000364404400003
- scopus:84945457222
- pmid:26141678
- ISSN
- 1873-2496
- DOI
- 10.1016/j.urolonc.2015.05.030
- language
- English
- LU publication?
- yes
- id
- 85907033-1504-4c28-8c63-fc17cf8d257a (old id 7750767)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26141678?dopt=Abstract
- date added to LUP
- 2016-04-01 09:48:53
- date last changed
- 2022-04-27 07:50:25
@article{85907033-1504-4c28-8c63-fc17cf8d257a,
abstract = {{Androgen deprivation therapy (ADT) is frequently used for the treatment of advanced prostate cancer. ADT is associated with numerous side effects related to its mode of action, namely the suppression of testosterone to castrate levels. Recently, several large retrospective studies have also reported an increased risk of diabetes and cardiovascular disease in men receiving ADT, although these risks have not been confirmed by prospective randomized trials. We review the literature to consider the risk of cardiovascular disease with different forms of ADT and examine in detail potential mechanisms by which any such risk could be mediated. Mechanisms discussed include the metabolic syndrome resulting from low testosterone level and the potential roles of testosterone flare, gonadotropin-releasing hormone receptors outside the pituitary gland, and altered levels of follicle-stimulating hormone. Finally, the clinical implications for men prescribed ADT for the treatment of advanced prostate cancer are considered.}},
author = {{Tivesten, Åsa and Pinthus, Jehonathan H and Clarke, Noel and Duivenvoorden, Wilhelmina and Nilsson, Jan}},
issn = {{1873-2496}},
language = {{eng}},
number = {{11}},
pages = {{464--475}},
publisher = {{Elsevier}},
series = {{Urologic Oncology}},
title = {{Cardiovascular risk with androgen deprivation therapy for prostate cancer: Potential mechanisms.}},
url = {{https://lup.lub.lu.se/search/files/15814588/1277672.pdf}},
doi = {{10.1016/j.urolonc.2015.05.030}},
volume = {{33}},
year = {{2015}},
}