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SOX11 and HIG-2 are cross-regulated and affect growth in mantle cell lymphoma.

Kuci, Venera LU ; Nordström, Lena LU ; Conrotto, Paolo LU and Ek, Sara LU (2016) In Leukemia & lymphoma
Abstract
The transcriptional factor SOX11 is a disease-defining antigen in mantle cell lymphoma (MCL) and absent in most non-malignant tissues. To explore the role of SOX11-related cell signaling, and potentially take benefit from these for targeted therapy, associated networks and proteins need to be defined. In this study, we used an inducible SOX11 knock-down system followed by gene expression analysis to identify co-regulated genes and associated signaling pathways. A limited number (n = 27) of significantly co-regulated genes were identified, including SETMAR, HIG-2, and CD24. Further analysis confirmed co-regulation of SOX11 with HIG-2 and CD24 at the protein level. Of major interest, knock-down of HIG-2 reduced SOX11 levels and increased... (More)
The transcriptional factor SOX11 is a disease-defining antigen in mantle cell lymphoma (MCL) and absent in most non-malignant tissues. To explore the role of SOX11-related cell signaling, and potentially take benefit from these for targeted therapy, associated networks and proteins need to be defined. In this study, we used an inducible SOX11 knock-down system followed by gene expression analysis to identify co-regulated genes and associated signaling pathways. A limited number (n = 27) of significantly co-regulated genes were identified, including SETMAR, HIG-2, and CD24. Further analysis confirmed co-regulation of SOX11 with HIG-2 and CD24 at the protein level. Of major interest, knock-down of HIG-2 reduced SOX11 levels and increased proliferation, the proteins are thus cross-regulated. HIG-2 was localized at the plasma cell membrane in both cell lines and primary MCL cells, and could potentially be of interest for targeted therapy. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Leukemia & lymphoma
publisher
Taylor & Francis
external identifiers
  • pmid:26757780
  • scopus:84954287501
  • wos:000381290600020
ISSN
1029-2403
DOI
10.3109/10428194.2015.1121257
project
CREATE Health
language
English
LU publication?
yes
id
511bf4c3-c336-4280-910c-e5b30c8a9cb7 (old id 8592279)
date added to LUP
2016-02-11 14:29:51
date last changed
2017-01-01 06:20:57
@article{511bf4c3-c336-4280-910c-e5b30c8a9cb7,
  abstract     = {The transcriptional factor SOX11 is a disease-defining antigen in mantle cell lymphoma (MCL) and absent in most non-malignant tissues. To explore the role of SOX11-related cell signaling, and potentially take benefit from these for targeted therapy, associated networks and proteins need to be defined. In this study, we used an inducible SOX11 knock-down system followed by gene expression analysis to identify co-regulated genes and associated signaling pathways. A limited number (n = 27) of significantly co-regulated genes were identified, including SETMAR, HIG-2, and CD24. Further analysis confirmed co-regulation of SOX11 with HIG-2 and CD24 at the protein level. Of major interest, knock-down of HIG-2 reduced SOX11 levels and increased proliferation, the proteins are thus cross-regulated. HIG-2 was localized at the plasma cell membrane in both cell lines and primary MCL cells, and could potentially be of interest for targeted therapy.},
  author       = {Kuci, Venera and Nordström, Lena and Conrotto, Paolo and Ek, Sara},
  issn         = {1029-2403},
  language     = {eng},
  month        = {01},
  publisher    = {Taylor & Francis},
  series       = {Leukemia & lymphoma},
  title        = {SOX11 and HIG-2 are cross-regulated and affect growth in mantle cell lymphoma.},
  url          = {http://dx.doi.org/10.3109/10428194.2015.1121257},
  year         = {2016},
}